Overview of pyrimidine metabolism and related diseases

Authors

Roel Hacking , Denise Slenter , Egon Willighagen , Martina Summer-Kutmon , Irene Hemel , Friederike Ehrhart , and Finterly Hu

Cited In

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Organism

Homo sapiens

Communities

Inborn Errors of Metabolism (IEM) Pathways Rare Diseases

Annotations

Pathway Ontology: inborn error of purine-pyrimidine metabolism pathway pyrimidine metabolic pathway dihydropyrimidine dehydrogenase deficiency pathway beta-ureidopropionase deficiency pathway disease pathway orotic aciduria 1 pathway

Disease Ontology: dihydropyrimidine dehydrogenase deficiency pyrimidine metabolic disorder orotic aciduria

Participants

References

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9. Kaymak I, Maier CR, Schmitz W, Campbell AD, Dankworth B, Ade CP, et al. Mevalonate Pathway Provides Ubiquinone to Maintain Pyrimidine Synthesis and Survival in p53-Deficient Cancer Cells Exposed to Metabolic Stress. Cancer Res. 2020 Jan 15;80(2):189–203. PubMed Europe PMC Scholia