Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake. Source: KEGG (http://www.genome.jp/dbget-bin/www_bget?pathway+dre03320)

Authors

Kristina Hanspers , Eric Weitz , and Egon Willighagen

Cited In

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Organism

Danio rerio

Communities

Annotations

Pathway Ontology: peroxisome proliferator-activated receptor signaling pathway

Participants

References

1. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Desvergne B, Wahli W. Endocr Rev. 1999 Oct;20(5):649–88. PubMed Europe PMC Scholia
2. The mode of action of thiazolidinediones. Hauner H. Diabetes Metab Res Rev. 2002;18 Suppl 2:S10-5. PubMed Europe PMC Scholia
3. Peroxisome proliferator-activated receptor alpha target genes. Mandard S, Müller M, Kersten S. Cell Mol Life Sci. 2004 Feb;61(4):393–416. PubMed Europe PMC Scholia
4. PPAR gamma as a metabolic regulator: insights from genomics and pharmacology. Savage DB. Expert Rev Mol Med. 2005 Jan 25;7(1):1–16. PubMed Europe PMC Scholia
5. The structures and functions of peroxisome proliferator-activated receptors (PPARs). Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T. Nihon Rinsho. 2005 Apr;63(4):557–64. PubMed Europe PMC Scholia
6. PPARs-mediated intracellular signal transduction. Fujii H. Nihon Rinsho. 2005 Apr;63(4):565–71. PubMed Europe PMC Scholia
7. PPARs target genes. Takada I, Kato S. Nihon Rinsho. 2005 Apr;63(4):573–7. PubMed Europe PMC Scholia
8. Endogenous ligands for PPARs. Inoue H. Nihon Rinsho. 2005 Apr;63(4):578–83. PubMed Europe PMC Scholia
9. The many faces of PPARgamma. Lehrke M, Lazar MA. Cell. 2005 Dec 16;123(6):993–9. PubMed Europe PMC Scholia
10. From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions. Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W. Prog Lipid Res. 2006 Mar;45(2):120–59. PubMed Europe PMC Scholia
11. PPAR gamma and human metabolic disease. Semple RK, Chatterjee VKK, O’Rahilly S. J Clin Invest. 2006 Mar;116(3):581–9. PubMed Europe PMC Scholia
12. Transcriptional regulation of metabolism. Desvergne B, Michalik L, Wahli W. Physiol Rev. 2006 Apr;86(2):465–514. PubMed Europe PMC Scholia