Liver steatosis adverse outcome pathway (WP4010)
This liver steatosis AOP starts from the top with different molecular initiating events going down towards liver steatosis. The black nodes are Key Events and green nodes are molecular pathways. Adverse outcome pathway liver steatosis; the accumulation of lipids in hepatocytes, caused either by over-nutrition, visceral obesity, metabolic syndrome, or environmental toxins. Liver steatosis can be divided into three main categories: alcoholic liver disease (ALD), non-alcoholic liver disease (NAFLD), and toxicant-associated liver disease (TAFLD).[https://pubmed.ncbi.nlm.nih.gov/28210688/ Review on liver steatosis]
AuthorsJJv Heijden , Alex Pico , Marvin Martens , Jeroen Kearns , Chesley De Windt , Eric Weitz , and Finterly Hu
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OrganismsHomo sapiens Adverse Outcome Pathways
Cell Type Ontologyhepatocyte
Disease Ontologyfatty liver disease