This pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluripotency and self-renewal. A central organizing theme of this pathway are known drug targets that promote self-renewal or pluripotency (BIO and IQ-1) and implicated upstream regulators of the core pluripotency transcriptional components (e.g. Nanog). It should be noted that it is unclear whether all the depicted components participate in this pathway in human embryonic stem cells. Interactions and object/gene groups for the pathway exist for the majority of components. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP399 CPTAC Assay Portal].

Authors

Nathan Salomonis , Thomas Kelder , Martijn Van Iersel , Alex Pico , Kristina Hanspers , Daniela Digles , Egon Willighagen , Zahra Roudbari , Eric Weitz , Martina Summer-Kutmon , and Finterly Hu

Cited In

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Organism

Homo sapiens

Communities

Annotations

Cell Type Ontology: pluripotent stem cell

Pathway Ontology: Wnt signaling, canonical pathway Wnt signaling pathway

Participants

References

2. Sato N, Brivanlou AH. Manipulation of self-renewal in human embryonic stem cells through a novel pharmacological GSK-3 inhibitor. Methods Mol Biol. 2006;331:115–28. PubMed Europe PMC Scholia
3. Miyabayashi T, Teo J-L, Yamamoto M, McMillan M, Nguyen C, Kahn M. Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5668–73. PubMed Europe PMC Scholia
4. Yi F, Pereira L, Merrill BJ. Tcf3 functions as a steady-state limiter of transcriptional programs of mouse embryonic stem cell self-renewal. Stem Cells. 2008 Aug;26(8):1951–60. PubMed Europe PMC Scholia
5. Zhang X, Zhang J, Wang T, Esteban MA, Pei D. Esrrb activates Oct4 transcription and sustains self-renewal and pluripotency in embryonic stem cells. J Biol Chem. 2008 Dec 19;283(51):35825–33. PubMed Europe PMC Scholia
6. Chen C-Y, Weng Y-H, Chien K-Y, Lin K-J, Yeh T-H, Cheng Y-P, et al. (G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD. Cell Death Differ. 2012 Oct;19(10):1623–33. PubMed Europe PMC Scholia