The paper (1) describes insulin signalling in human adipocytes under normal and diabetic states using mathematical models based on experimental data. This model corresponds to insulin signalling under normal conditions. Insulin signalling under diabetic condition is represented in WP3635. The model has been converted to GPML using the PathSBML plugin from PathVIsio, importing the model BIOMD0000000448 from the BioModels Database directly. The layout has been improved manually. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3634 CPTAC Assay Portal]

Authors

Anwesha Bohler , Kristina Hanspers , Andika Tan , Egon Willighagen , Ryan Miller , Chris Evelo , and Eric Weitz

Cited In

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Organism

Homo sapiens

Communities

Annotations

Cell Type Ontology: fat cell

Pathway Ontology: insulin signaling pathway

Participants

References

1. Brännmark C, Nyman E, Fagerholm S, Bergenholm L, Ekstrand E-M, Cedersund G, et al. Insulin signaling in type 2 diabetes: experimental and modeling analyses reveal mechanisms of insulin resistance in human adipocytes. J Biol Chem. 2013 Apr 5;288(14):9867–80. PubMed Europe PMC Scholia