miR-517 relationship with ARCN1 and USP1 (WP3596)

Homo sapiens

Schematic summarizing predicted miR-517a relationships with ARCN1 and USP1. A genomewide miRNA mimic toxicity screen indicates common and selective vulnerabilities of epithelial ovarian cancer cells. miR-517a targets a common vulnerability, primarily via its target ARCN1. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3596 CPTAC Assay Portal].
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Authors

Kristina Hanspers , Ryan Miller , and Martina Summer-Kutmon

Cited In

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Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: regulatory pathway

Participants

Label Type Compact Identifier Comment
USP1 GeneProduct ensembl:ENSG00000162607
ARCN1 GeneProduct ensembl:ENSG00000095139
p21 GeneProduct ensembl:ENSG00000124762
ID1 GeneProduct ensembl:ENSG00000125968
ID2 GeneProduct ensembl:ENSG00000115738
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References

  1. Shields BB, Pecot CV, Gao H, McMillan E, Potts M, Nagel C, et al. A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression. Mol Syst Biol. 2015 Dec 11;11(12):842. PubMed Europe PMC Scholia