G proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades. G proteins are so called because they function as "molecular switches". They alternate from 'inactive' guanosine diphosphate (GDP) to 'active' guanosine triphosphate (GTP), which is a binding state, and which proceeds to regulate downstream cell processes. Source: [[wikipedia:G_protein|Wikipedia]] Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP35 CPTAC Assay Portal]

Authors

Nathan Salomonis , Alex Pico , Bruce Conklin , Charles Redfern , Thomas Kelder , Samuel Sklar , Zahra Roudbari , Martina Summer-Kutmon , Kristina Hanspers , and Eric Weitz

Cited In

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Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: G protein mediated signaling pathway via Galphaq family G protein mediated signaling pathway G protein mediated signaling pathway via Galpha12/Galpha13 family G protein mediated signaling pathway via Galphas family G protein mediated signaling pathway via Galphai family

Participants

References

1. G proteins: a family of signal transducers. Stryer L, Bourne HR. Annu Rev Cell Biol. 1986;2:391–419. PubMed Europe PMC Scholia
2. G protein pathways. Neves SR, Ram PT, Iyengar R. Science. 2002 May 31;296(5573):1636–9. PubMed Europe PMC Scholia