Synthesis and degradation of ketone bodies (WP349)
Rattus norvegicus
Ketone bodies are three water-soluble compounds that are produced as by-products when fatty acids are broken down for energy in the liver and kidney. They are used as a source of energy in the heart and brain. In the brain, they are a vital source of energy during fasting. Source: [[wikipedia:Ketone_bodies|Wikipedia]]
Authors
Niradiz Reyes , Thomas Kelder , Kristina Hanspers , Susan Coort , Daniela Digles , and Eric WeitzCited In
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Organism
Rattus norvegicusCommunities
Annotations
Pathway Ontology: ketone bodies metabolic pathway
Participants
| Label | Type | Compact Identifier | Comment |
|---|---|---|---|
| Acetyl-CoA | Metabolite | cas:72-89-9 | |
| Acetoacetyl-CoA | Metabolite | cas:1420-36-6 | |
| 3-Hydroxybutyric acid | Metabolite | hmdb:HMDB0000357 | |
| Acetoacetic acid | Metabolite | hmdb:HMDB0000060 | |
| 3-Hydroxy-3-methylglutaryl-CoA | Metabolite | cas:1553-55-5 | |
| Acetyl-CoA | Metabolite | cas:72-89-9 | |
| Hmgcl | GeneProduct | ncbigene:79238 | |
| Acat1 | GeneProduct | ncbigene:25014 | |
| Hmgcs2 | GeneProduct | ncbigene:24450 | |
| Oxct1 | GeneProduct | ncbigene:690163 | |
| Bdh1 | GeneProduct | ncbigene:117099 |
References
- Fukao T, Lopaschuk GD, Mitchell GA. Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry. Prostaglandins Leukot Essent Fatty Acids. 2004 Mar;70(3):243–51. PubMed Europe PMC Scholia