Ketone bodies synthesis and degradation (WP311)

Homo sapiens

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Ketone bodies are three water-soluble compounds (acetoacetate, beta-hydroxybutyrate, and the spontaneous breakdown product of acetoacetate, acetone) that are produced as by-products when fatty acids are broken down for energy in the liver and kidney. They are used as a source of energy in the heart and brain. In the brain, they are a vital source of energy during fasting. Source: [[wikipedia:Ketone_bodies|Wikipedia]]

Authors

Niradiz Reyes , Thomas Kelder , Kristina Hanspers , Adrien Defay , Daniela Digles , Chris Evelo , Egon Willighagen , and Eric Weitz

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

ketone bodies biosynthetic pathway ketone bodies degradation pathway ketone bodies metabolic pathway

Participants
Query Drugst.One

Label Type Compact Identifier Comment
Acetyl-CoA Metabolite cas:72-89-9
Acetoacetyl-CoA Metabolite cas:1420-36-6
3-Hydroxy-butyrate Metabolite pubchem.compound:441
Acetoacetate Metabolite pubchem.compound:6971017
3-Hydroxy-3-methylglutaryl-CoA Metabolite cas:1553-55-5
Acetyl-CoA Metabolite cas:72-89-9
HMGCL GeneProduct ncbigene:3155
ACAT1 GeneProduct ncbigene:38
HMGCS2 GeneProduct ncbigene:3158
OXCT1 GeneProduct ncbigene:5019
BDH GeneProduct ncbigene:622

References

  1. Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry. Fukao T, Lopaschuk GD, Mitchell GA. Prostaglandins Leukot Essent Fatty Acids. 2004 Mar;70(3):243–51. PubMed Europe PMC Scholia