Interactome of polycomb repressive complex 2 (PRC2) (WP2916)

Homo sapiens

A proposed interactome of Polycomb repressive complex 2 (PRC2), based on proteomics. PRC2 has histone methyltransferase activity and primarily trimethylates histone H3 on lysine 27, a mark of transcriptionally silent chromatin, and is required for initial targeting of genomic region (PRC Response Elements or PRE) to be silenced. Based on figure 1B in [ Shen et al].
last edited


Kristina Hanspers and Jonathan Mélius

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Homo sapiens



Pathway Ontology: regulatory pathway


Label Type Compact Identifier Comment
MTF2 GeneProduct ensembl:ENSG00000143033
ELL GeneProduct ensembl:ENSG00000105656
JMJ GeneProduct ensembl:ENSG00000008083
TRIM35 GeneProduct ensembl:ENSG00000104228
STK38 GeneProduct ensembl:ENSG00000112079
THRAP3 GeneProduct ensembl:ENSG00000054118
BCLAF1 GeneProduct ensembl:ENSG00000029363
STK38 GeneProduct ensembl:ENSG00000112079
SETX GeneProduct ensembl:ENSG00000107290
MORC3 GeneProduct ensembl:ENSG00000159256
RBBP7 GeneProduct ensembl:ENSG00000102054
AEBP2 GeneProduct ensembl:ENSG00000139154
EZH2 GeneProduct ensembl:ENSG00000106462
EED GeneProduct ensembl:ENSG00000074266
SUZ12 GeneProduct ensembl:ENSG00000178691
EZH1 GeneProduct ensembl:ENSG00000108799
RBBP4 GeneProduct ensembl:ENSG00000162521


  1. Regulation of cyclin D1 RNA stability by SNIP1. Bracken CP, Wall SJ, Barré B, Panov KI, Ajuh PM, Perkins ND. Cancer Res. 2008 Sep 15;68(18):7621–8. PubMed Europe PMC Scholia
  2. Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. Shen X, Kim W, Fujiwara Y, Simon MD, Liu Y, Mysliwiec MR, et al. Cell. 2009 Dec 24;139(7):1303–14. PubMed Europe PMC Scholia