Vascular smooth muscle contraction (WP2912)
Bos taurus
Vascular smooth muscle refers to the particular type of smooth muscle found within, and composing the majority of the wall of blood vessels. The main function of vascular smooth muscle tonus is to regulate the caliber of the blood vessels in the body. Excessive vasoconstriction leads to high blood pressure, while excessive vasodilation as in shock leads to low blood pressure (http://en.wikipedia.org/wiki/Vascular_smooth_muscle).
Authors
Zahra Roudbari , Martina Summer-Kutmon , Jonathan Mélius , and Marianthi KalafatiCited In
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Organism
Bos taurusCommunities
Annotations
Pathway Ontology: regulatory pathway
Participants
Label | Type | Compact Identifier | Comment |
---|---|---|---|
Ca2+ | Metabolite | chebi:29108 | |
Ca2+ | Metabolite | chebi:29108 | |
CAMP | Metabolite | chebi:17489 | |
Angiotensin II | Metabolite | chebi:2719 | |
BNP | Metabolite | chebi:80234 | |
IP3 | Metabolite | chebi:16595 | |
ANP | Metabolite | chebi:80233 | |
PGI2 | Metabolite | chebi:15552 | |
Arachidonate | Metabolite | chebi:15843 | |
Norepinephrine | Metabolite | chebi:18357 | |
Adrenomedullin | Metabolite | chebi:80339 | |
K+ | Metabolite | chebi:29103 | |
EET | Metabolite | chebi:34157 | |
DAG | Metabolite | chebi:18035 | |
20-HETE | Metabolite | chebi:34306 | |
NO | Metabolite | chebi:16480 | |
Ca2+ | Metabolite | chebi:29108 | |
CNP | Metabolite | chebi:80235 | |
cGMP | Metabolite | chebi:16356 | |
Endothelin | Metabolite | chebi:80240 | |
K+ | Metabolite | chebi:29103 | |
CGRP | Metabolite | chebi:80337 | |
vasopressin | Metabolite | chebi:34543 | |
ADCY1 | GeneProduct | ncbigene:281601 | |
ADCY9 | GeneProduct | ncbigene:525482 | |
ROCK2 | GeneProduct | ncbigene:282041 | |
CALM | GeneProduct | ncbigene:326597 | |
CALM1 | GeneProduct | ncbigene:617095 | |
PLA2G2C | GeneProduct | ncbigene:504978 | |
phospholipase A2 | GeneProduct | ncbigene:615045 | |
IRAG | GeneProduct | ncbigene:281918 | |
GNA11 | GeneProduct | ncbigene:281788 | |
CALM3 | GeneProduct | ncbigene:520277 | |
PPP1CA | GeneProduct | ncbigene:516175 | |
PPP1R12A | GeneProduct | ncbigene:538606 | |
ADCY8 | GeneProduct | ncbigene:535017 | |
ADCY2 | GeneProduct | ncbigene:510708 | |
PRKCA | GeneProduct | ncbigene:282001 | |
NPR-A | GeneProduct | ncbigene:533048 | |
PLA2G2D4 | GeneProduct | ncbigene:503625 | |
ADRA1B | GeneProduct | ncbigene:407140 | |
CYP4A11 | GeneProduct | ncbigene:511890 | |
RAF1 | GeneProduct | ncbigene:521196 | |
ARHGEF12 | GeneProduct | ncbigene:503575 | |
CACNA1D | GeneProduct | ncbigene:408013 | |
MYLK4 | GeneProduct | ncbigene:518025 | |
ARHGEF11 | GeneProduct | ncbigene:511220 | |
KCNMB1 | GeneProduct | ncbigene:407176 | |
CACNA1F | GeneProduct | ncbigene:509779 | |
CYP4A22 | GeneProduct | ncbigene:516085 | |
MYL6 | GeneProduct | ncbigene:281341 | |
phospholipase A2 | GeneProduct | ncbigene:104974671 | |
KCNMB2 | GeneProduct | ncbigene:534568 | |
MYL9 | GeneProduct | ncbigene:505964 | |
ITPR2 | GeneProduct | ncbigene:281878 | |
ACTG2 | GeneProduct | ncbigene:281595 | |
PLA2G6 | GeneProduct | ncbigene:535381 | |
PRKCB | GeneProduct | ncbigene:282325 | |
CALML5 | GeneProduct | ncbigene:520404 | |
PLA2G4E | GeneProduct | ncbigene:526364 | |
KCNMB4 | GeneProduct | ncbigene:520448 | |
PLA2G4F | GeneProduct | ncbigene:522866 | |
ADCY5 | GeneProduct | ncbigene:505740 | |
PRKCD | GeneProduct | ncbigene:505708 | |
ADCY3 | GeneProduct | ncbigene:535603 | |
BRAF | GeneProduct | ncbigene:536051 | |
PLCB1 | GeneProduct | ncbigene:287026 | |
PRKCH | GeneProduct | ncbigene:518542 | |
CACNA1C | GeneProduct | ensembl:ENSBTAG00000010660 | |
PLA2G2A | GeneProduct | ncbigene:521383 | |
MYLK2 | GeneProduct | ncbigene:533378 | |
PLA2G10 | GeneProduct | ncbigene:613966 | |
PLCB4 | GeneProduct | ncbigene:281985 | |
PRKCE | GeneProduct | ncbigene:507041 | |
PRKACA | GeneProduct | ncbigene:282322 | |
AGTR1 | GeneProduct | ncbigene:281607 | |
PTGIR | GeneProduct | ncbigene:520278 | |
MAPK1 | GeneProduct | ncbigene:327672 | |
MAP2K1 | GeneProduct | ncbigene:533199 | |
PLCB2 | GeneProduct | ncbigene:508888 | |
PLA2G2A | GeneProduct | ncbigene:507201 | |
PRKX | GeneProduct | ncbigene:505773 | |
ARHGEF1 | GeneProduct | ncbigene:513377 | |
GUCY1A2 | GeneProduct | ncbigene:613600 | |
PPP1R12C | GeneProduct | ncbigene:512431 | |
PLA2G2E | GeneProduct | ncbigene:506243 | |
ACTA2 | GeneProduct | ncbigene:515610 | |
PLA2G2D1 | GeneProduct | ncbigene:494318 | |
GNA13 | GeneProduct | ncbigene:505611 | |
ITPR3 | GeneProduct | ncbigene:281879 | |
PPP1CC | GeneProduct | ncbigene:282318 | |
KCNMB3 | GeneProduct | ncbigene:539609 | |
ADORA2B | GeneProduct | ncbigene:529760 | |
PLA2G1B | GeneProduct | ncbigene:282457 | |
PLCB3 | GeneProduct | ncbigene:515669 | |
RAMP3 | GeneProduct | ncbigene:613547 | |
NPR-B | GeneProduct | ncbigene:281357 | |
ITPR1 | GeneProduct | ncbigene:317697 | |
Gs | GeneProduct | ncbigene:281793 | |
MYL6B | GeneProduct | ncbigene:515421 | |
CPI-17 | GeneProduct | ncbigene:615348 | |
RAMP2 | GeneProduct | ncbigene:504230 | |
RhOA | GeneProduct | ncbigene:338049 | |
PLA2G3 | GeneProduct | ncbigene:527631 | |
CACNA1S | GeneProduct | ensembl:ENSBTAG00000047491 | |
PRKCG | GeneProduct | ncbigene:282002 | |
PRKCQ | GeneProduct | ncbigene:505901 | |
GNAQ | GeneProduct | ncbigene:536654 | |
CALCRL | GeneProduct | ncbigene:527140 | |
PLA2G12B | GeneProduct | ncbigene:100337447 | |
ADRA1A | GeneProduct | ncbigene:282134 | |
ADCY7 | GeneProduct | ncbigene:281603 | |
MYLK3 | GeneProduct | ncbigene:526379 | |
ADORA2A | GeneProduct | ncbigene:617828 | |
ROCK1 | GeneProduct | ncbigene:785911 | |
CALML6 | GeneProduct | ncbigene:617412 | |
MAP2K2 | GeneProduct | ncbigene:510434 | |
GUCY1B3 | GeneProduct | ncbigene:282433 | |
PLA2G5 | GeneProduct | ncbigene:614911 | |
MAPK3 | GeneProduct | ncbigene:531391 | |
ADCY6 | GeneProduct | ncbigene:509936 | |
MYLK | GeneProduct | ncbigene:338037 | |
KCNU1 | GeneProduct | ncbigene:524144 | |
EDNRA | GeneProduct | ncbigene:281749 | |
PLA2G4A | GeneProduct | ncbigene:525072 | |
PRKACB | GeneProduct | ncbigene:282323 | |
ADCY4 | GeneProduct | ncbigene:788151 | |
PPP1CB | GeneProduct | ncbigene:538829 | |
CaD | GeneProduct | ncbigene:281660 | |
AVPR1B | GeneProduct | ncbigene:282861 | |
ADRA1D | GeneProduct | ncbigene:539543 | |
AVPR1A | GeneProduct | ncbigene:538439 | |
PLA2G2F | GeneProduct | ncbigene:541294 | |
KCNMA1 | GeneProduct | ncbigene:282573 | |
PLA2G12A | GeneProduct | ncbigene:527214 | |
GNA12 | GeneProduct | ncbigene:515159 | |
RAMP1 | GeneProduct | ncbigene:617017 | |
PLA2G4D | GeneProduct | ncbigene:531209 | |
PLA2G4B | GeneProduct | ncbigene:505485 | |
ARAF | GeneProduct | ncbigene:540421 | |
CALM2 | GeneProduct | ncbigene:100297344 | |
PPP1R12B | GeneProduct | ncbigene:100337338 | |
GUCY1A3 | GeneProduct | ncbigene:281216 | |
CACNA1F | GeneProduct | ncbigene:509779 | |
CACNA1D | GeneProduct | ncbigene:408013 | |
CACNA1S | GeneProduct | ncbigene:100337204 | |
CACNA1C | GeneProduct | ncbigene:408015 | |
KCNMB2 | GeneProduct | ncbigene:534568 | |
KCNU1 | GeneProduct | ncbigene:524144 | |
KCNMB3 | GeneProduct | ncbigene:539609 | |
KCNMB4 | GeneProduct | ncbigene:520448 | |
KCNMB1 | GeneProduct | ncbigene:407176 | |
KCNMA1 | GeneProduct | ncbigene:282573 | |
ITPR2 | GeneProduct | ncbigene:281878 | |
ITPR1 | GeneProduct | ncbigene:317697 | |
ITPR3 | GeneProduct | ncbigene:281879 | |
MYLK2 | GeneProduct | ncbigene:533378 | |
MYLK | GeneProduct | ncbigene:338037 | |
MYLK4 | GeneProduct | ncbigene:518025 | |
MYLK3 | GeneProduct | ncbigene:526379 | |
ACTG2 | GeneProduct | ncbigene:281595 | |
MYL6 | GeneProduct | ncbigene:281341 | |
MYL9 | GeneProduct | ncbigene:505964 | |
ACTA2 | GeneProduct | ncbigene:515610 | |
MYL6B | GeneProduct | ncbigene:515421 | |
PPP1CC | GeneProduct | ncbigene:282318 | |
PPP1CB | GeneProduct | ncbigene:538829 | |
PPP1R12C | GeneProduct | ncbigene:512431 | |
PPP1CA | GeneProduct | ncbigene:516175 | |
PPP1R12B | GeneProduct | ensembl:ENSBTAG00000011772 | |
PPP1R12A | GeneProduct | ncbigene:538606 |