Liver X receptor pathway (WP2874)

Homo sapiens

The liver X receptor (LXR) is a nuclear receptor involved in the regulation of liver-specific processes, such as cholesterol, fatty acid and glucose homeostasis. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2874 CPTAC Assay Portal]
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Authors

Rianne Fijten , Egon Willighagen , Kristina Hanspers , Friederike Ehrhart , Martina Summer-Kutmon , Jonathan Mélius , Alex Pico , and Eric Weitz

Cited In

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Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: regulatory pathway

Participants

Label Type Compact Identifier Comment
LXR ligand Metabolite chebi:86029 T3
Ligand Metabolite chebi:86029
Ligand Metabolite chebi:86029
NR1H3 GeneProduct ncbigene:10062 nuclear receptor subfamily 1, group H, member 3
NR1H3 GeneProduct ncbigene:10062 nuclear receptor subfamily 1, group H, member 3
NR1H3 GeneProduct ncbigene:10062 nuclear receptor subfamily 1, group H, member 3
RXRA GeneProduct ncbigene:6256 retinoid X receptor, alpha
RXRA GeneProduct ncbigene:6256 retinoid X receptor, alpha
ABCG8 GeneProduct ncbigene:64241 ATP-binding cassette, sub-family G (WHITE), member 8
CYP3A4 GeneProduct ncbigene:1576 cytochrome P450, family 3, subfamily A, polypeptide 4
ABCG5 GeneProduct ncbigene:64240 ATP-binding cassette, sub-family G (WHITE), member 5
CYP2B6 GeneProduct ncbigene:1555 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP7A1 GeneProduct ncbigene:1581 cytochrome P450, family 7, subfamily A, polypeptide 1 , is not affected in human
SREBF1 GeneProduct ncbigene:6720 sterol regulatory element binding transcription factor 1
FASN GeneProduct ncbigene:2194 fatty acid synthase
SCD GeneProduct ncbigene:6319
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References

  1. The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways. Cai Y, Konishi T, Han G, Campwala KH, French SW, Wan YJY. Eur J Pharm Sci. 2002 Feb;15(1):89–96. PubMed Europe PMC Scholia
  2. Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR. Handschin C, Meyer UA. Arch Biochem Biophys. 2005 Jan 15;433(2):387–96. PubMed Europe PMC Scholia
  3. A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer. Xu RX, Lambert MH, Wisely BB, Warren EN, Weinert EE, Waitt GM, et al. Mol Cell. 2004 Dec 22;16(6):919–28. PubMed Europe PMC Scholia
  4. Crosstalk of thyroid hormone receptor and liver X receptor in lipid metabolism and beyond [Review]. Hashimoto K, Mori M. Endocr J. 2011;58(11):921–30. PubMed Europe PMC Scholia
  5. Pathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants. Fijten RRR, Jennen DGJ, van Delft JHM. Curr Drug Metab. 2013 Dec;14(10):1022–8. PubMed Europe PMC Scholia