Matrix metalloproteinases (WP278)

Rattus norvegicus

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily. Collectively they are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine in/activation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis and host defense. Source: [[wikipedia:Matrix_metalloproteinase|Wikipedia]]
last edited


Kdahlquist , Manny Ramirez , Kristina Hanspers , Thomas Kelder , Daniela Digles , and Eric Weitz

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Rattus norvegicus



Pathway Ontology: cell-extracellular matrix signaling pathway


Label Type Compact Identifier Comment
Mmp2 GeneProduct ncbigene:81686
Mmp9 GeneProduct ncbigene:81687
Mmp7 GeneProduct ncbigene:25335
Mmp12 GeneProduct ncbigene:117033
Mmp20 GeneProduct ncbigene:300341
Mmp10 GeneProduct ncbigene:117061
Mmp3 GeneProduct ncbigene:171045
Mmp11 GeneProduct ncbigene:25481
Mmp19 GeneProduct ncbigene:304608
Mmp14 GeneProduct ncbigene:81707
Mmp15 GeneProduct ncbigene:291848
Mmp16 GeneProduct ncbigene:65205
Mmp17 GeneProduct ncbigene:288626
MMP24 GeneProduct ncbigene:83513
Timp2 GeneProduct ncbigene:29543
Timp3 GeneProduct ncbigene:25358
Timp4 GeneProduct ncbigene:680130
Bsg GeneProduct ncbigene:25246
Tnf GeneProduct ncbigene:24835
Mmp28 GeneProduct ncbigene:303384
Mmp25 GeneProduct ensembl:ENSRNOG00000029621
Mmp27 GeneProduct ncbigene:300340
Tcf20 GeneProduct ncbigene:366964
Mmp21 GeneProduct ncbigene:293573
Mmp1a GeneProduct ncbigene:300339
Mmp8 GeneProduct ncbigene:63849
Mmp13 GeneProduct ncbigene:171052
Timp1 GeneProduct ncbigene:116510
Mmp23 GeneProduct ncbigene:94339


  1. Matrix metalloproteinases: effectors of development and normal physiology. Vu TH, Werb Z. Genes Dev. 2000 Sep 1;14(17):2123–33. PubMed Europe PMC Scholia