Blood clotting cascade (WP272)
Homo sapiens
Coagulation is a complex process by which blood forms clots. It is an important part of hemostasis (the cessation of blood loss from a damaged vessel), wherein a damaged blood vessel wall is covered by a platelet and fibrin-containing clot to stop bleeding and begin repair of the damaged vessel. Disorders of coagulation can lead to an increased risk of bleeding (hemorrhage) or clotting (thrombosis). Source: [[wikipedia:Coagulation|Wikipedia]] Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP272 CPTAC Assay Portal]
Authors
Andrew Kwa , Kristina Hanspers , Thomas Kelder , Andra Waagmeester , Luis , Martina Summer-Kutmon , Egon Willighagen , and Eric WeitzCited In
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Organism
Homo sapiensCommunities
Annotations
Pathway Ontology: coagulation cascade pathway
Participants
| Label | Type | Compact Identifier | Comment |
|---|---|---|---|
| Fibrin | Metabolite | chebi:5054 | |
| Zinc | Metabolite | hmdb:HMDB0015532 | |
| Factor XIIa | GeneProduct | ensembl:ENSG00000131187 | |
| Factor XIIIa | GeneProduct | ensembl:ENSG00000143278 | |
| Factor IXa | GeneProduct | ensembl:ENSG00000101981 | |
| Factor VIIIa | GeneProduct | ensembl:ENSG00000185010 | |
| Factor XIa | GeneProduct | ensembl:ENSG00000088926 | |
| Factor VIIa | GeneProduct | ensembl:ENSG00000057593 | |
| Factor X | GeneProduct | ensembl:ENSG00000126218 | |
| Factor II | GeneProduct | ensembl:ENSG00000180210 | |
| Factor XII | GeneProduct | ensembl:ENSG00000131187 | |
| KLKB1 | GeneProduct | ensembl:ENSG00000164344 | |
| FGG | GeneProduct | ensembl:ENSG00000171557 | |
| Factor X | GeneProduct | ensembl:ENSG00000126218 | |
| Plasminogen | GeneProduct | ensembl:ENSG00000122194 | |
| Tissue Factor | GeneProduct | ensembl:ENSG00000117525 | |
| Factor Va | GeneProduct | ensembl:ENSG00000198734 | |
| Factor IX | GeneProduct | ensembl:ENSG00000101981 | |
| Factor VIII A1 | GeneProduct | ensembl:ENSG00000277203 | |
| Thrombin (II) | GeneProduct | ensembl:ENSG00000180210 | |
| PLAU | GeneProduct | ensembl:ENSG00000122861 | |
| FGB | GeneProduct | ensembl:ENSG00000171564 | |
| KLK1 | GeneProduct | ensembl:ENSG00000167748 | |
| VWF | GeneProduct | ensembl:ENSG00000110799 | |
| Factor V | GeneProduct | ensembl:ENSG00000198734 | |
| Factor XIIIb | GeneProduct | ensembl:ENSG00000143278 | |
| Factor Xa | GeneProduct | ensembl:ENSG00000126218 | |
| Factor XI | GeneProduct | ensembl:ENSG00000088926 | |
| SERPINF2 | GeneProduct | ensembl:ENSG00000167711 | |
| tPA | GeneProduct | ensembl:ENSG00000104368 | |
| SERPINB2 | GeneProduct | ensembl:ENSG00000197632 | |
| SERPINE1 | GeneProduct | ensembl:ENSG00000106366 | |
| Factor VIII | GeneProduct | ensembl:ENSG00000185010 | |
| Factor VII | GeneProduct | ensembl:ENSG00000057593 | |
| FGA | GeneProduct | ensembl:ENSG00000171560 | |
| Plasmin | GeneProduct | ensembl:ENSG00000122194 | |
| Factor Va | GeneProduct | ensembl:ENSG00000198734 | |
| Factor Xa | GeneProduct | ensembl:ENSG00000126218 |
References
- The current status of coagulation. Luchtman-Jones L, Broze GJ Jr. Ann Med. 1995 Feb;27(1):47–52. PubMed Europe PMC Scholia