Latent membrane protein 1 (LMP1) of the Ebstein-Barr Virus (EBV) elicits its oncogenice effects through the activation of several downstream pathways suchs as Pi3K/akt, IRF4, and NFkB pathways. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP262 CPTAC Assay Portal]

Authors

Thomas Kelder , Martijn Van Iersel , Kristina Hanspers , Christine Chichester , Alex Pico , Zahra Roudbari , Martina Summer-Kutmon , Roelod , and Eric Weitz

Cited In

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Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: Epstein-Barr virus infection pathway oxidative phosphorylation pathway

Participants

References

1. Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, et al. TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB. J Biol Chem. 2006 Mar 24;281(12):7863–72. PubMed Europe PMC Scholia
2. Song Y-J, Jen K-Y, Soni V, Kieff E, Cahir-McFarland E. IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation. Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2689–94. PubMed Europe PMC Scholia
3. Lee J-S, Lee J-Y, Son JW, Oh J-H, Shin D-M, Yuk J-M, et al. Expression and regulation of the CC-chemokine ligand 20 during human tuberculosis. Scand J Immunol. 2008 Jan;67(1):77–85. PubMed Europe PMC Scholia
4. Battaglia F, Delfino S, Merello E, Puppo M, Piva R, Varesio L, et al. Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB. J Leukoc Biol. 2008 Mar;83(3):648–62. PubMed Europe PMC Scholia