Apoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and membrane blebbing characterize apoptosis in general. Mitochondria remain morphologically unchanged. In 1972 Kerr et al introduced the concept of apoptosis as a distinct form of "cell-death", and the mechanisms of various apoptotic pathways are still being revealed today. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP254 CPTAC Assay Portal]

Authors

Alexander C. Zambon , Alex Pico , Thomas Kelder , Susan Coort , Angelika , Beth Lawlor , Martijn Van Iersel , Marc Gillespie , Kristina Hanspers , Jildau Bouwman , Anders Riutta , Nuno , Egon Willighagen , Martina Summer-Kutmon , Marianthi Kalafati , Josip , and Anam

Cited In

• 
• 
• 
• 
• 
• 
• 
• 
• 
• 
• 
• 
• 

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organism

Homo sapiens

Communities

CPTAC PancCanNet

Annotations

Pathway Ontology: regulatory pathway cell death pathway apoptotic cell death pathway

Participants

References

1. Lakin ND, Jackson SP. Regulation of p53 in response to DNA damage. Oncogene. 1999 Dec 13;18(53):7644–55. PubMed Europe PMC Scholia
2. Mott JL, Kobayashi S, Bronk SF, Gores GJ. mir-29 regulates Mcl-1 protein expression and apoptosis. Oncogene. 2007 Sep 13;26(42):6133–40. PubMed Europe PMC Scholia
3. Bose I, Ghosh B. The p53-MDM2 network: from oscillations to apoptosis. J Biosci. 2007 Aug;32(5):991–7. PubMed Europe PMC Scholia
4. Park S-Y, Lee JH, Ha M, Nam J-W, Kim VN. miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42. Nat Struct Mol Biol. 2009 Jan;16(1):23–9. PubMed Europe PMC Scholia