Glial cells, consisting of microglia, astrocytes, and oligodendrocyte lineage cells as their major components, constitute a large fraction of the mammalian brain. Originally considered as purely non-functional glue for neurons, decades of research have highlighted the importance as well as further functions of glial cells. Source: https://doi.org/10.3389%2Ffncel.2017.00024. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2276 CPTAC Assay Portal]

Authors

Nathan Salomonis , Alex Pico , Ryan Miller , Denise Slenter , Egon Willighagen , Kristina Hanspers , and Eric Weitz

Cited In

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Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: signaling pathway signaling pathway pertinent to development

Cell Type Ontology: stem cell neural cell glial cell

Participants

References

1. Down-regulation of GAP-43 During Oligodendrocyte Development and Lack of Expression by Astrocytes In Vivo: Implications for Macroglial Differentiation. Curtis R, Hardy R, Reynolds R, Spruce BA, Wilkin GP. Eur J Neurosci. 1991;3(9):876–86. PubMed Europe PMC Scholia
2. Tubulin polymerization-promoting protein (TPPP/p25) is critical for oligodendrocyte differentiation. Lehotzky A, Lau P, Tokési N, Muja N, Hudson LD, Ovádi J. Glia. 2010 Jan 15;58(2):157–68. PubMed Europe PMC Scholia
3. Mouse intermittent hypoxia mimicking apnoea of prematurity: effects on myelinogenesis and axonal maturation. Cai J, Tuong CM, Zhang Y, Shields CB, Guo G, Fu H, et al. J Pathol. 2012 Feb;226(3):495–508. PubMed Europe PMC Scholia