Glial cell differentiation (WP2276)

Homo sapiens

Glial cells, consisting of microglia, astrocytes, and oligodendrocyte lineage cells as their major components, constitute a large fraction of the mammalian brain. Originally considered as purely non-functional glue for neurons, decades of research have highlighted the importance as well as further functions of glial cells. Source: Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]
last edited


Nathan Salomonis , Alex Pico , Ryan Miller , Denise Slenter , Egon Willighagen , Kristina Hanspers , and Eric Weitz

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Homo sapiens



Pathway Ontology: signaling pathway signaling pathway pertinent to development

Cell Type Ontology: stem cell neural cell glial cell


Label Type Compact Identifier Comment
PLP1 GeneProduct ensembl:ENSG00000123560
CNP GeneProduct ensembl:ENSG00000173786
TPPP GeneProduct ensembl:ENSG00000171368
miR-206 GeneProduct ensembl:ENSG00000207604
GAP43 GeneProduct ensembl:ENSG00000172020
MSN GeneProduct ensembl:ENSG00000147065
MBP GeneProduct ensembl:ENSG00000197971
MAG GeneProduct ensembl:ENSG00000105695


  1. Down-regulation of GAP-43 During Oligodendrocyte Development and Lack of Expression by Astrocytes In Vivo: Implications for Macroglial Differentiation. Curtis R, Hardy R, Reynolds R, Spruce BA, Wilkin GP. Eur J Neurosci. 1991;3(9):876–86. PubMed Europe PMC Scholia
  2. Tubulin polymerization-promoting protein (TPPP/p25) is critical for oligodendrocyte differentiation. Lehotzky A, Lau P, Tokési N, Muja N, Hudson LD, Ovádi J. Glia. 2010 Jan 15;58(2):157–68. PubMed Europe PMC Scholia
  3. Mouse intermittent hypoxia mimicking apnoea of prematurity: effects on myelinogenesis and axonal maturation. Cai J, Tuong CM, Zhang Y, Shields CB, Guo G, Fu H, et al. J Pathol. 2012 Feb;226(3):495–508. PubMed Europe PMC Scholia