Non-canonical Wnt pathway (WP215)

Danio rerio

last edited


Gabby Krens , Kristina Hanspers , Daniela Digles , Alex Pico , Egon Willighagen , Denise Slenter , and Eric Weitz

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Danio rerio



Pathway Ontology: Wnt signaling, non-canonical pathway


Label Type Compact Identifier Comment
Ca2+ Metabolite chebi:22984
GBP GeneProduct ncbigene:30719
vangl2 GeneProduct ensembl:ENSDARG00000027397
vent GeneProduct ncbigene:64810
ntl GeneProduct ncbigene:30399
wnt11r GeneProduct ensembl:ENSDARG00000014796
wif1 GeneProduct ncbigene:30476 wnt inhibitory factor 1
cdc42l2 GeneProduct ncbigene:556226
camk1g GeneProduct ncbigene:335654
APC GeneProduct ncbigene:386762
cyclin D1 GeneProduct ncbigene:30222
abi1a GeneProduct ensembl:ENSDARG00000010155
fzd8a GeneProduct ncbigene:58073
cdc42 GeneProduct ncbigene:336839
wnt2 GeneProduct ncbigene:30127
rac2 GeneProduct ncbigene:415151
otx2 GeneProduct ncbigene:30501
fzd9 GeneProduct ncbigene:58023
wnt11 GeneProduct ensembl:ENSDARG00000004256 silberblick
rfzd8b GeneProduct ncbigene:58072
fzd3 GeneProduct ncbigene:30371
prkcbb GeneProduct ensembl:ENSDARG00000022254
tcf3 / tcf7l1a GeneProduct ncbigene:30523
cdc42l GeneProduct ensembl:ENSDARG00000040158
wnt10b GeneProduct ncbigene:30308
wnt7 GeneProduct ncbigene:60633
RhoAd GeneProduct ncbigene:436718
mapk10 GeneProduct ensembl:ENSDARG00000102730
daam1 GeneProduct ncbigene:378457
cdx4 GeneProduct ncbigene:30330
axin1 GeneProduct ncbigene:57931 masterblind
mapk8b GeneProduct ensembl:ENSDARG00000009870
ved GeneProduct ncbigene:368201
sqt GeneProduct ncbigene:30153
gelsolin GeneProduct ncbigene:321099
lef GeneProduct ncbigene:30701
rock2b GeneProduct ensembl:ENSDARG00000004877
sp5a GeneProduct ensembl:ENSDARG00000076571
wnt4b GeneProduct ncbigene:57928
rock2a GeneProduct ensembl:ENSDARG00000017500
actr3 GeneProduct ensembl:ENSDARG00000091138
fzd7b GeneProduct ncbigene:30412
wnt3l GeneProduct ncbigene:60632
tcl GeneProduct ncbigene:386615 secreted frizzled-related protein
ptpn11a GeneProduct ensembl:ENSDARG00000020334
NLK GeneProduct ncbigene:405892 Nem like kinase
mapk9 GeneProduct ensembl:ENSDARG00000077364
tcf3b / tcf7l1b GeneProduct ncbigene:30556
dvl3 GeneProduct ncbigene:80972 deshevelled3
cki GeneProduct ncbigene:30328
wnt8a GeneProduct ncbigene:30122
groucho1 GeneProduct ncbigene:30205
wnt16 GeneProduct ncbigene:404628
prickle1a GeneProduct ensembl:ENSDARG00000040649
LRP5 GeneProduct ncbigene:554087
chd GeneProduct ncbigene:30161
evlb GeneProduct ensembl:ENSDARG00000099720
has2 GeneProduct ensembl:ENSDARG00000036987
pfn2 GeneProduct ensembl:ENSDARG00000003952
groucho3 GeneProduct ncbigene:83411
prkcbb GeneProduct ensembl:ENSDARG00000022254
cfl2 GeneProduct ensembl:ENSDARG00000014106
mkp3 GeneProduct ncbigene:353314
sfzd1 GeneProduct ncbigene:402843 secreted frizzled-related protein
wnt5a GeneProduct zfin:ZDB-GENE-060328-3
vangl1 GeneProduct ensembl:ENSDARG00000004305
prickle2 GeneProduct ncbigene:368250
wnt2b GeneProduct ncbigene:359837
eve1 GeneProduct ncbigene:30335
oep GeneProduct ncbigene:30304
csk GeneProduct ensembl:ENSDARG00000067996
dvl2 GeneProduct ncbigene:323630 deshevelled2
boz GeneProduct ncbigene:30170
fzd7a GeneProduct ensembl:ENSDARG00000060004
rhoca GeneProduct ensembl:ENSDARG00000021309
axin2 GeneProduct ncbigene:58080
vox GeneProduct ncbigene:64807
nap1l1 GeneProduct ensembl:ENSDARG00000101813
wnt1 GeneProduct ncbigene:30128
evla GeneProduct ensembl:ENSDARG00000035650
pfn2l GeneProduct ensembl:ENSDARG00000012682
gsc GeneProduct ncbigene:30212
fzd4 GeneProduct ncbigene:30363
pea GeneProduct ncbigene:30700
dvl2 GeneProduct ncbigene:323630
wnt8b GeneProduct ncbigene:30144
RhoAb GeneProduct ncbigene:336001
otx1 GeneProduct ncbigene:30500
camk2d GeneProduct ncbigene:436815
dharma/boz GeneProduct ncbigene:30170
bmp4 GeneProduct ncbigene:30612
rac3 GeneProduct ncbigene:437027
celsr1b GeneProduct ensembl:ENSDARG00000058259
knypek GeneProduct ncbigene:118437
c-myc GeneProduct ncbigene:30686
fgf8 GeneProduct ncbigene:30538
E12 / tcf3 GeneProduct ncbigene:30310
cap1 GeneProduct ensembl:ENSDARG00000016350
Tak1 GeneProduct ncbigene:553788
tbx6 GeneProduct ncbigene:30254
capgb GeneProduct ensembl:ENSDARG00000099672
pak1 GeneProduct ncbigene:373103
dia1 GeneProduct ncbigene:336553
fzd2 GeneProduct ncbigene:30370
dvl3 GeneProduct ncbigene:80972
ERK2 / MAPK1 GeneProduct ncbigene:360144
Yes1 GeneProduct ncbigene:407620
src GeneProduct ensembl:ENSDARG00000008107
tmsb4x GeneProduct ensembl:ENSDARG00000077777
fzd10 GeneProduct ncbigene:30366
rock1 GeneProduct ensembl:ENSDARG00000058993
wnt7a GeneProduct ncbigene:565714
rac1a GeneProduct ensembl:ENSDARG00000074849
capga GeneProduct ensembl:ENSDARG00000035560
quo GeneProduct ncbigene:321031
ERK1 / MAPK3 GeneProduct ncbigene:399480
erm GeneProduct ncbigene:30452
limk1 GeneProduct ncbigene:735292
celsr1a GeneProduct ensembl:ENSDARG00000069185
spry4 GeneProduct ncbigene:114437
smo GeneProduct ncbigene:30225
csk GeneProduct ensembl:ENSDARG00000067996
stat3 GeneProduct ncbigene:30767
c-jun GeneProduct ncbigene:335916
icat GeneProduct ncbigene:58117 beta-catenin-interacting protein
fyna GeneProduct ensembl:ENSDARG00000011370
fzd8c GeneProduct ncbigene:30364
lim1 GeneProduct ncbigene:30463
fzd10 GeneProduct ensembl:ENSDARG00000068213
cfl1 GeneProduct ensembl:ENSDARG00000021124
groucho2 GeneProduct ncbigene:30206
catenin-beta 2 GeneProduct ncbigene:324004 ’catenin (cadherin-associated protein), beta 2’
flh GeneProduct ncbigene:30260
mitfa GeneProduct ncbigene:30080
bmp2b GeneProduct ncbigene:30632
prickle1 GeneProduct ncbigene:368249
spry2 GeneProduct ncbigene:335098
gata2 GeneProduct ncbigene:30480
sfzd5 GeneProduct ncbigene:117510 secreted frizzled-related protein
gsk3b GeneProduct ncbigene:30654
catenin-beta 1 GeneProduct ncbigene:30265 ’catenin (cadherin-associated protein), beta 1 ’
rhoac GeneProduct ensembl:ENSDARG00000099709
wnt4a GeneProduct ncbigene:30123
wnt5b GeneProduct ncbigene:30105
tbx16 / spt GeneProduct ncbigene:30264
Sp5l GeneProduct ncbigene:324261
dact2 / drapper GeneProduct ncbigene:337795 ’dapper homolog 2, antagonist of beta-catenin’
actr2a GeneProduct ensembl:ENSDARG00000052438
fz12 GeneProduct ncbigene:30275
ephin B1 GeneProduct ncbigene:114377
frzb GeneProduct ncbigene:30119
wnt10a GeneProduct ncbigene:30171
limk2 GeneProduct ensembl:ENSDARG00000005104
abi1a GeneProduct ensembl:ENSDARG00000010155
RhoAa GeneProduct ncbigene:406411
fgf3 GeneProduct ncbigene:30549
tcf4 GeneProduct ncbigene:30510
rac1b GeneProduct ensembl:ENSDARG00000087954
rac1l GeneProduct ensembl:ENSDARG00000054649
actr2b GeneProduct ensembl:ENSDARG00000070076
rac1a GeneProduct ensembl:ENSDARG00000074849
rac1b GeneProduct ensembl:ENSDARG00000087954
rac1l GeneProduct ensembl:ENSDARG00000054649


  1. ERK1 and ERK2 MAPK are key regulators of distinct gene sets in zebrafish embryogenesis. Krens SFG, Corredor-Adámez M, He S, Snaar-Jagalska BE, Spaink HP. BMC Genomics. 2008 Apr 28;9:196. PubMed Europe PMC Scholia