IL-17 signaling pathway (WP2112)

Homo sapiens

Interleukin 17 is a family of cytokines that acts as potent mediators in delayed-type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site of inflammation, similar to Interferon gamma. IL-17 is produced by T-helper cells and is induced by IL-23 which results in destructive tissue damage in delayed-type reactions. Interleukin 17 as a family functions as proinflammatory cytokines that responds to the invasion of the immune system by extracellular pathogens. Interleukin 17 acts synergistically with tumor necrosis factor and interleukin-1. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]
last edited


Shamith Samarajiwa , Kristina Hanspers , Martina Summer-Kutmon , Ryan Miller , Alex Pico , Andra Waagmeester , and Eric Weitz

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Homo sapiens



Pathway Ontology: cytokine mediated signaling pathway


Label Type Compact Identifier Comment
TRAF6 GeneProduct ncbigene:7189
IL17RD GeneProduct ncbigene:54756
IKBKG GeneProduct ncbigene:8517
MAPK1 GeneProduct ncbigene:5594 p38
RELA GeneProduct ncbigene:5970
GSK3B GeneProduct ncbigene:2932
SP1 GeneProduct ncbigene:6667
NFKB1 GeneProduct ncbigene:4790
IL17RE GeneProduct ncbigene:132014
IL17A GeneProduct ncbigene:3605
AKT1 GeneProduct ncbigene:207
IL17F GeneProduct ncbigene:112744
TRAF3IP2 GeneProduct ncbigene:10758
JAK2 GeneProduct ncbigene:3717
IKBKB GeneProduct ncbigene:3551
IL17D GeneProduct ncbigene:53342
STAT3 GeneProduct ncbigene:6774
NFKBIB GeneProduct ncbigene:4793
IL17C GeneProduct ncbigene:27189
IL25 GeneProduct ncbigene:64806
IL17RC GeneProduct ncbigene:84818
MAP3K7 GeneProduct ncbigene:6885
CEBPB GeneProduct ncbigene:1051
IL17RA GeneProduct ncbigene:23765
IL17RB GeneProduct ncbigene:55540
MAP3K14 GeneProduct ncbigene:9020 NIK or p38
IL17B GeneProduct ncbigene:27190
CEBPD GeneProduct ncbigene:1052
MAPK1 GeneProduct ncbigene:5594
JAK1 GeneProduct ncbigene:3716
TRAF3 GeneProduct ncbigene:7187
TRAF3IP2 GeneProduct ncbigene:10758
MAP3K7 GeneProduct ncbigene:6885
TRAF6 GeneProduct ncbigene:7189
TRAF3IP2 GeneProduct ncbigene:10758
NFKB1 GeneProduct ncbigene:4790
RELA GeneProduct ncbigene:5970
MAPK3 GeneProduct ncbigene:5595
PI3K Protein ncbigene:5290


  1. IL-17 family: cytokines, receptors and signaling. Gu C, Wu L, Li X. Cytokine. 2013 Nov;64(2):477–85. PubMed Europe PMC Scholia