Interleukin 17 is a family of cytokines that acts as potent mediators in delayed-type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site of inflammation, similar to Interferon gamma. IL-17 is produced by T-helper cells and is induced by IL-23 which results in destructive tissue damage in delayed-type reactions. Interleukin 17 as a family functions as proinflammatory cytokines that responds to the invasion of the immune system by extracellular pathogens. Interleukin 17 acts synergistically with tumor necrosis factor and interleukin-1. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2112 CPTAC Assay Portal]

Authors

Shamith Samarajiwa , Kristina Hanspers , Martina Summer-Kutmon , Ryan Miller , Alex Pico , Andra Waagmeester , and Eric Weitz

Cited In

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Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: cytokine mediated signaling pathway

Participants

References

1. IL-17 family: cytokines, receptors and signaling. Gu C, Wu L, Li X. Cytokine. 2013 Nov;64(2):477–85. PubMed Europe PMC Scholia