Heart development (WP2067)

Mus musculus

This pathway has been largely adapted from an article by Deepak Srivastava, Cell. 2006 Sep 22;126(6):1037-48. In this pathway are known transcription factors, miRNAs and regulatory proteins that impact the regional specificity of the human heart. Activating signals are indicated by arrows while inhibitory signals are indicated by T-bars. Special thanks to Kim Cordes for her assistance in revising this pathway, based on recent heart development research.
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last edited

Authors

Nathan Salomonis , Kristina Hanspers , Jonathan Mélius , and Eric Weitz

Cited In

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Organism

Mus musculus

Communities

Annotations

Cell Type Ontology: smooth muscle cell neural crest derived vascular associated smooth muscle cell

Disease Ontology: heart disease

Pathway Ontology: regulatory pathway

Participants

Label Type Compact Identifier Comment
Tbx20 GeneProduct ensembl:ENSMUSG00000031965
Tbx2 GeneProduct ensembl:ENSMUSG00000000093
Nkx2-5 GeneProduct ensembl:ENSMUSG00000015579
Tbx5 GeneProduct ensembl:ENSMUSG00000018263
Bmp10 GeneProduct ensembl:ENSMUSG00000030046
Hand1 GeneProduct ensembl:ENSMUSG00000037335
Irx4 GeneProduct ensembl:ENSMUSG00000021604
Nkx2-5 GeneProduct ensembl:ENSMUSG00000015579
Foxh1 GeneProduct ensembl:ENSMUSG00000033837
Mef2c GeneProduct ensembl:ENSMUSG00000005583
Smyd1 GeneProduct ensembl:ENSMUSG00000055027
Tbx20 GeneProduct ensembl:ENSMUSG00000031965
Hand2 GeneProduct ensembl:ENSMUSG00000038193
Notch1 GeneProduct ensembl:ENSMUSG00000026923
Hey1 GeneProduct ensembl:ENSMUSG00000040289
Srf GeneProduct ensembl:ENSMUSG00000015605
Gata4 GeneProduct ensembl:ENSMUSG00000021944
Isl1 GeneProduct ensembl:ENSMUSG00000042258
miR1-1 GeneProduct ensembl:ENSMUSG00000070144
Hey2 GeneProduct ensembl:ENSMUSG00000019789
Shh GeneProduct ensembl:ENSMUSG00000002633
Foxa2 GeneProduct ensembl:ENSMUSG00000037025
Foxc2 GeneProduct ensembl:ENSMUSG00000046714
Nkx2-5 GeneProduct ensembl:ENSMUSG00000015579
Tbx1 GeneProduct ensembl:ENSMUSG00000037477
Foxc1 GeneProduct ensembl:ENSMUSG00000050295
Pitx2 GeneProduct ensembl:ENSMUSG00000028023
Fgf8 GeneProduct ensembl:ENSMUSG00000025219
Fgf10 GeneProduct ensembl:ENSMUSG00000021732
Tbx5 GeneProduct ensembl:ENSMUSG00000018263
Bmp2 GeneProduct ensembl:ENSMUSG00000027358
Tbx2 GeneProduct ensembl:ENSMUSG00000000093
Ptpn11 GeneProduct ensembl:ENSMUSG00000043733
Nfatc1 GeneProduct ensembl:ENSMUSG00000033016
Vegfa GeneProduct ensembl:ENSMUSG00000023951
Nfatc2 GeneProduct ensembl:ENSMUSG00000027544
Nfatc3 GeneProduct ensembl:ENSMUSG00000031902
Nfatc4 GeneProduct ensembl:ENSMUSG00000023411
Vegfb GeneProduct ensembl:ENSMUSG00000024962
Vegfc GeneProduct ensembl:ENSMUSG00000031520
Nkx2-5 GeneProduct ensembl:ENSMUSG00000015579
Tbx5 GeneProduct ensembl:ENSMUSG00000018263
Gata4 GeneProduct ensembl:ENSMUSG00000021944
Ctnnb1 GeneProduct ensembl:ENSMUSG00000006932
Notch1 GeneProduct ensembl:ENSMUSG00000026923
Bhlhe40 GeneProduct ensembl:ENSMUSG00000030103 In other species, this is BHLHB2
Smad1 GeneProduct ensembl:ENSMUSG00000031681
Smad4 GeneProduct ensembl:ENSMUSG00000024515
Bmp4 GeneProduct ensembl:ENSMUSG00000021835
Bmpr1A GeneProduct ensembl:ENSMUSG00000021796
Bmpr2 GeneProduct ensembl:ENSMUSG00000067336
Bmp2 GeneProduct ensembl:ENSMUSG00000027358
Gata6 GeneProduct ensembl:ENSMUSG00000005836
Mef2c GeneProduct ensembl:ENSMUSG00000005583
Srf GeneProduct ensembl:ENSMUSG00000015605
Nkx2-5 GeneProduct ensembl:ENSMUSG00000015579
miR143 GeneProduct ensembl:ENSMUSG00000065445
miR145 GeneProduct ensembl:ENSMUSG00000065592
Gata4 GeneProduct ensembl:ENSMUSG00000021944
Erbb3 GeneProduct ensembl:ENSMUSG00000018166
Mapk1 GeneProduct ensembl:ENSMUSG00000063358
Tbx5 GeneProduct ensembl:ENSMUSG00000018263
Mef2c GeneProduct ensembl:ENSMUSG00000005583
Gata4 GeneProduct ensembl:ENSMUSG00000021944
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References

  1. Development of heart valves requires Gata4 expression in endothelial-derived cells. Rivera-Feliciano J, Lee KH, Kong SW, Rajagopal S, Ma Q, Springer Z, et al. Development. 2006 Sep;133(18):3607–18. PubMed Europe PMC Scholia
  2. Making or breaking the heart: from lineage determination to morphogenesis. Srivastava D. Cell. 2006 Sep 22;126(6):1037–48. PubMed Europe PMC Scholia
  3. An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Prall OWJ, Menon MK, Solloway MJ, Watanabe Y, Zaffran S, Bajolle F, et al. Cell. 2007 Mar 9;128(5):947–59. PubMed Europe PMC Scholia
  4. BMP and BMP receptor expression during murine organogenesis. Danesh SM, Villasenor A, Chong D, Soukup C, Cleaver O. Gene Expr Patterns. 2009 Jun;9(5):255–65. PubMed Europe PMC Scholia
  5. Tbx1 regulates the BMP-Smad1 pathway in a transcription independent manner. Fulcoli FG, Huynh T, Scambler PJ, Baldini A. PLoS One. 2009 Jun 25;4(6):e6049. PubMed Europe PMC Scholia
  6. miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Cordes KR, Sheehy NT, White MP, Berry EC, Morton SU, Muth AN, et al. Nature. 2009 Aug 6;460(7256):705–10. PubMed Europe PMC Scholia
  7. A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate. Kwon C, Qian L, Cheng P, Nigam V, Arnold J, Srivastava D. Nat Cell Biol. 2009 Aug;11(8):951–7. PubMed Europe PMC Scholia