Alzheimer's disease and miRNA effects (WP2059)
Homo sapiens
This pathway displays current genes, proteolytic events and other processes associated with the progression of Alzheimer's disease. Note: mitochondrial associated genes Cx I through Cx V are not currently included, as these correspond to over a hundred distinct factors. See below source URL for more information. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2059 CPTAC Assay Portal]
Authors
Nathan Salomonis , Thomas Kelder , Kristina Hanspers , Alex Pico , Jonathan Mlius , Egon Willighagen , Friederike Ehrhart , Lovnish Thakur , Susan Coort , and Eric WeitzCited In
Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.
Organism
Homo sapiensCommunities
Diseases Rare DiseasesAnnotations
Pathway Ontology: disease pathway Alzheimer's disease pathway
Disease Ontology: Alzheimer's disease
Participants
Label | Type | Compact Identifier | Comment |
---|---|---|---|
NO | Metabolite | hmdb:HMDB0003378 | |
Fe2+ | Metabolite | hmdb:HMDB0000692 | |
Hydrogen peroxide | Metabolite | hmdb:HMDB0003125 | |
AGEs | Metabolite | chebi:84123 | |
beta-amyloid protein 40 | Metabolite | chebi:64646 | |
superoxide | Metabolite | chebi:18421 | |
IP3 | Metabolite | hmdb:HMDB0001498 | |
PI3P | Metabolite | chebi:17283 | |
Cu+ | Metabolite | hmdb:HMDB0000657 | |
Ca2+ | Metabolite | hmdb:HMDB0000464 | |
Ca2+ | Metabolite | hmdb:HMDB0000464 | |
Ca2+ | Metabolite | hmdb:HMDB0000464 | |
ONOO- | Metabolite | hmdb:HMDB0002179 | |
Ca2+ | Metabolite | hmdb:HMDB0000464 | |
Ca2+ | Metabolite | hmdb:HMDB0000464 | |
Ca2+ | Metabolite | hmdb:HMDB0000464 | |
beta-amyloid protein 42 | Metabolite | chebi:64647 | |
beta-amyloid protein 40 | Metabolite | chebi:64646 | |
beta-amyloid protein 42 | Metabolite | chebi:64647 | |
PIP3 | Metabolite | hmdb:HMDB0004249 | |
beta-amyloid protein 40 | Metabolite | chebi:64646 | |
beta-amyloid protein 42 | Metabolite | chebi:64647 | |
Ca2+ | Metabolite | hmdb:HMDB0000464 | |
Ca2+ | Metabolite | hmdb:HMDB0000464 | |
beta-amyloid protein 40 | Metabolite | chebi:64646 | |
beta-amyloid protein 42 | Metabolite | chebi:64647 | |
Ca2+ | Metabolite | hmdb:HMDB0000464 | |
beta-amyloid protein 40 | Metabolite | chebi:64646 | |
beta-amyloid protein 42 | Metabolite | chebi:64647 | |
IRS2 | GeneProduct | ensembl:ENSG00000185950 | |
ATG14 | GeneProduct | ensembl:ENSG00000126775 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
P3 peptide | GeneProduct | uniprot:P05067 | |
TNFRSF1A | GeneProduct | ensembl:ENSG00000067182 | |
p50 ATF6 | GeneProduct | ensembl:ENSG00000118217 | |
NAE1 | GeneProduct | ensembl:ENSG00000159593 | |
APP | GeneProduct | ensembl:ENSG00000142192 | |
MAPT | GeneProduct | ensembl:ENSG00000186868 | |
RTN3 | GeneProduct | ensembl:ENSG00000133318 | |
APP intracellular domain | GeneProduct | uniprot:P05067 | |
MIR101 | GeneProduct | ensembl:ENSG00000199135 | |
APBB1 | GeneProduct | ensembl:ENSG00000166313 | |
GAPDH | GeneProduct | ensembl:ENSG00000111640 | |
ADAM10 | GeneProduct | ensembl:ENSG00000137845 | |
BACE1 | GeneProduct | ensembl:ENSG00000186318 | |
PSENEN | GeneProduct | ensembl:ENSG00000205155 | |
PSEN1 | GeneProduct | ensembl:ENSG00000080815 | |
NCSTN | GeneProduct | ensembl:ENSG00000162736 | |
APH1A | GeneProduct | ensembl:ENSG00000117362 | |
IDE | GeneProduct | ensembl:ENSG00000119912 | |
MME | GeneProduct | ensembl:ENSG00000196549 | |
LPL | GeneProduct | ensembl:ENSG00000175445 | |
APOE | GeneProduct | ensembl:ENSG00000130203 | |
LRP1 | GeneProduct | ensembl:ENSG00000123384 | |
FAS | GeneProduct | ensembl:ENSG00000026103 | |
TNFRSF1A | GeneProduct | ensembl:ENSG00000067182 | |
FADD | GeneProduct | ensembl:ENSG00000168040 | |
CASP8 | GeneProduct | ensembl:ENSG00000064012 | |
HSD17B10 | GeneProduct | ensembl:ENSG00000072506 | |
BID | GeneProduct | ensembl:ENSG00000015475 | |
CYCS | GeneProduct | ensembl:ENSG00000172115 | |
CALM1 | GeneProduct | ensembl:ENSG00000198668 | |
BAD | GeneProduct | ensembl:ENSG00000002330 | |
CALM2 | GeneProduct | ensembl:ENSG00000143933 | |
CALM3 | GeneProduct | ensembl:ENSG00000160014 | |
CALML3 | GeneProduct | ensembl:ENSG00000178363 | |
CALML5 | GeneProduct | ensembl:ENSG00000178372 | |
PPP3CA | GeneProduct | ensembl:ENSG00000138814 | |
PPP3CB | GeneProduct | ensembl:ENSG00000107758 | |
PPP3CC | GeneProduct | ensembl:ENSG00000120910 | |
PPP3R1 | GeneProduct | ensembl:ENSG00000221823 | |
PPP3R2 | GeneProduct | ensembl:ENSG00000188386 | |
ADAM17 | GeneProduct | ensembl:ENSG00000151694 | |
PSEN2 | GeneProduct | ensembl:ENSG00000143801 | |
APAF1 | GeneProduct | ensembl:ENSG00000120868 | |
CASP9 | GeneProduct | ensembl:ENSG00000132906 | |
CASP3 | GeneProduct | ensembl:ENSG00000164305 | |
SNCA | GeneProduct | ensembl:ENSG00000145335 | |
GRIN1 | GeneProduct | ensembl:ENSG00000176884 | |
CACNA1C | GeneProduct | ensembl:ENSG00000151067 | |
GRIN2A | GeneProduct | ensembl:ENSG00000183454 | |
GRIN2B | GeneProduct | ensembl:ENSG00000273079 | |
GRIN2C | GeneProduct | ensembl:ENSG00000161509 | |
GRIN2D | GeneProduct | ensembl:ENSG00000105464 | |
CACNA1D | GeneProduct | ensembl:ENSG00000157388 | |
CACNA1F | GeneProduct | ensembl:ENSG00000102001 | |
CACNA1S | GeneProduct | ensembl:ENSG00000081248 | |
GNAQ | GeneProduct | ensembl:ENSG00000156052 | |
PLCB1 | GeneProduct | ensembl:ENSG00000182621 | |
PLCB2 | GeneProduct | ensembl:ENSG00000137841 | |
PLCB3 | GeneProduct | ensembl:ENSG00000149782 | |
PLCB4 | GeneProduct | ensembl:ENSG00000101333 | |
TNF | GeneProduct | ensembl:ENSG00000232810 | |
IL1B | GeneProduct | ensembl:ENSG00000125538 | |
MAPK1 | GeneProduct | ensembl:ENSG00000100030 | |
MAPK3 | GeneProduct | ensembl:ENSG00000102882 | |
CASP12 | GeneProduct | ensembl:ENSG00000204403 | |
RYR3 | GeneProduct | ensembl:ENSG00000198838 | |
ATP2A2 | GeneProduct | ensembl:ENSG00000174437 | |
ATP2A1 | GeneProduct | ensembl:ENSG00000196296 | |
ATP2A3 | GeneProduct | ensembl:ENSG00000074370 | |
EIF2AK3 | GeneProduct | ensembl:ENSG00000172071 | |
ERN1 | GeneProduct | ensembl:ENSG00000178607 | |
ATF6 | GeneProduct | ensembl:ENSG00000118217 | |
ITPR1 | GeneProduct | ensembl:ENSG00000150995 | |
ITPR2 | GeneProduct | ensembl:ENSG00000123104 | |
ITPR3 | GeneProduct | ensembl:ENSG00000096433 | |
CAPN1 | GeneProduct | ensembl:ENSG00000014216 | |
CAPN2 | GeneProduct | ensembl:ENSG00000162909 | |
CDK5R1 / p35 | GeneProduct | ensembl:ENSG00000176749 | |
CDK5R1 / p25 | GeneProduct | ensembl:ENSG00000176749 | |
NOS1 | GeneProduct | ensembl:ENSG00000089250 | |
CDK5 | GeneProduct | ensembl:ENSG00000164885 | |
MAPT | GeneProduct | ensembl:ENSG00000186868 | |
CASP3 | GeneProduct | ensembl:ENSG00000164305 | |
CASP7 | GeneProduct | ensembl:ENSG00000165806 | |
MIR29A | GeneProduct | ensembl:ENSG00000284032 | |
MIR29B1 | GeneProduct | ncbigene:407024 | |
MIR29C | GeneProduct | ensembl:ENSG00000284214 | |
MIR132 | GeneProduct | ncbigene:406921 | |
MIR132 | GeneProduct | ncbigene:406921 | |
RTN4 | GeneProduct | ensembl:ENSG00000115310 | |
INS | GeneProduct | ncbigene:3630 | |
INSR | GeneProduct | ensembl:ENSG00000171105 | |
IRS1 | GeneProduct | ensembl:ENSG00000169047 | |
IRS4 | GeneProduct | ensembl:ENSG00000133124 | |
PPID | GeneProduct | ensembl:ENSG00000171497 | |
MCU | GeneProduct | ensembl:ENSG00000156026 | |
AKT1 | GeneProduct | ensembl:ENSG00000142208 | |
AKT2 | GeneProduct | ensembl:ENSG00000105221 | |
AKT3 | GeneProduct | ensembl:ENSG00000117020 | |
PIK3CA | GeneProduct | ensembl:ENSG00000121879 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18706 |
PIK3R1 | GeneProduct | ensembl:ENSG00000145675 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18708 |
PIK3R2 | GeneProduct | ensembl:ENSG00000105647 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18709 |
PIK3CB | GeneProduct | ensembl:ENSG00000051382 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74769 |
PIK3CD | GeneProduct | ensembl:ENSG00000171608 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18707 |
PIK3R3 | GeneProduct | ensembl:ENSG00000117461 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75669 |
EIF2AK2 | GeneProduct | ensembl:ENSG00000055332 | |
MAPK8 | GeneProduct | ensembl:ENSG00000107643 | |
MAPK9 | GeneProduct | ensembl:ENSG00000050748 | |
MAPK10 | GeneProduct | ensembl:ENSG00000109339 | |
GPR83 | GeneProduct | ensembl:ENSG00000123901 | |
CHUK | GeneProduct | ensembl:ENSG00000213341 | |
IKBKB | GeneProduct | ensembl:ENSG00000104365 | |
CHRNA7 | GeneProduct | ensembl:ENSG00000175344 | |
CYBB | GeneProduct | ensembl:ENSG00000165168 | |
NOX1 | GeneProduct | ensembl:ENSG00000007952 | |
NOX4 | GeneProduct | ensembl:ENSG00000086991 | |
NFKB1 | GeneProduct | ensembl:ENSG00000109320 | |
RELA | GeneProduct | ncbigene:5970 | |
NRAS | GeneProduct | ensembl:ENSG00000213281 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18176 |
KRAS | GeneProduct | ensembl:ENSG00000133703 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16653 |
HRAS | GeneProduct | ensembl:ENSG00000174775 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15461 |
RAF1 | GeneProduct | ensembl:ENSG00000132155 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:110157 |
ARAF | GeneProduct | ensembl:ENSG00000078061 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:110157 |
BRAF | GeneProduct | ensembl:ENSG00000157764 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:110157 |
NOS2 | GeneProduct | ensembl:ENSG00000007171 | |
TNF | GeneProduct | ensembl:ENSG00000232810 | |
IL1A | GeneProduct | ensembl:ENSG00000115008 | |
IL1B | GeneProduct | ensembl:ENSG00000125538 | |
PTGS2 | GeneProduct | ensembl:ENSG00000073756 | |
IL6 | GeneProduct | ensembl:ENSG00000136244 | |
CSF1 | GeneProduct | ensembl:ENSG00000184371 | |
DKK1 | GeneProduct | ensembl:ENSG00000107984 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15461 |
DKK2 | GeneProduct | ensembl:ENSG00000155011 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15461 |
DKK4 | GeneProduct | ensembl:ENSG00000104371 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15461 |
MTOR | GeneProduct | ensembl:ENSG00000198793 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
ULK2 | GeneProduct | ensembl:ENSG00000083290 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
ULK1 | GeneProduct | ensembl:ENSG00000177169 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
ATG13 | GeneProduct | ensembl:ENSG00000175224 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
ATG101 | GeneProduct | ensembl:ENSG00000123395 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
RB1CC1 | GeneProduct | ensembl:ENSG00000023287 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
BECN1 | GeneProduct | ensembl:ENSG00000126581 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
BECN2 | GeneProduct | ensembl:ENSG00000196289 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
PIK3R4 | GeneProduct | ensembl:ENSG00000196455 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
NRBF2 | GeneProduct | ensembl:ENSG00000148572 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
PIK3C3 | GeneProduct | ensembl:ENSG00000078142 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
AMBRA1 | GeneProduct | ensembl:ENSG00000110497 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
ATG2A | GeneProduct | ensembl:ENSG00000110046 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
ATG2B | GeneProduct | ensembl:ENSG00000066739 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
WIPI1 | GeneProduct | ensembl:ENSG00000070540 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
WIPI2 | GeneProduct | ensembl:ENSG00000157954 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
PSEN1 | GeneProduct | ensembl:ENSG00000080815 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
GSK3B | GeneProduct | ensembl:ENSG00000082701 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
KLC3 | GeneProduct | ensembl:ENSG00000104892 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
KIF5A | GeneProduct | ensembl:ENSG00000155980 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
KIF5B | GeneProduct | ensembl:ENSG00000170759 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
KIF5C | GeneProduct | ensembl:ENSG00000168280 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
KLC1 | GeneProduct | ensembl:ENSG00000126214 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
KLC2 | GeneProduct | ensembl:ENSG00000174996 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
KLC4 | GeneProduct | ensembl:ENSG00000137171 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
TUBA1B | GeneProduct | ensembl:ENSG00000123416 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
TUBA3E | GeneProduct | ensembl:ENSG00000152086 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
TUBA3D | GeneProduct | ensembl:ENSG00000075886 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
TUBA8 | GeneProduct | ensembl:ENSG00000183785 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
TUBA4A | GeneProduct | ensembl:ENSG00000127824 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
TUBA3C | GeneProduct | ensembl:ENSG00000198033 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
TUBA1A | GeneProduct | ensembl:ENSG00000167552 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
TUBAL3 | GeneProduct | ensembl:ENSG00000178462 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
TUBA1C | GeneProduct | ensembl:ENSG00000167553 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
TUBB3 | GeneProduct | ensembl:ENSG00000258947 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
TUBB4A | GeneProduct | ensembl:ENSG00000104833 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
TUBB4B | GeneProduct | ensembl:ENSG00000188229 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
TUBB | GeneProduct | ensembl:ENSG00000196230 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
TUBB8 | GeneProduct | ensembl:ENSG00000261456 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
TUBB2B | GeneProduct | ensembl:ENSG00000137285 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
TUBB2A | GeneProduct | ensembl:ENSG00000137267 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
TUBB1 | GeneProduct | ensembl:ENSG00000101162 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
TUBB6 | GeneProduct | ensembl:ENSG00000176014 | SOS1; son of sevenless homolog 1 (Drosophila)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 |
WNT3A | GeneProduct | ncbigene:89780 | |
WNT7A | GeneProduct | ncbigene:7476 | |
WNT11 | GeneProduct | ncbigene:7481 | |
WNT1 | GeneProduct | ncbigene:7471 | |
WNT5B | GeneProduct | ncbigene:81029 | |
WNT2 | GeneProduct | ncbigene:7472 | |
WNT2B | GeneProduct | ncbigene:7482 | |
WNT6 | GeneProduct | ncbigene:7475 | |
WNT5A | GeneProduct | ncbigene:7474 | |
WNT16 | GeneProduct | ncbigene:51384 | |
WNT4 | GeneProduct | ncbigene:54361 | |
WNT3 | GeneProduct | ncbigene:7473 | |
WNT10B | GeneProduct | ncbigene:7480 | |
WNT7B | GeneProduct | ncbigene:7477 | |
WNT10A | GeneProduct | ncbigene:80326 | |
WNT16 | GeneProduct | ncbigene:51384 | |
FZD3 | GeneProduct | ncbigene:7976 | |
FZD8 | GeneProduct | ncbigene:8325 | |
LRP5 | GeneProduct | ncbigene:4041 | |
FZD10 | GeneProduct | ncbigene:11211 | |
FZD7 | GeneProduct | ncbigene:8324 | |
FZD4 | GeneProduct | ncbigene:6424 | |
FZD1 | GeneProduct | ncbigene:8321 | |
LRP6 | GeneProduct | ncbigene:4040 | |
FZD6 | GeneProduct | ncbigene:8323 | |
FZD5 | GeneProduct | ncbigene:7855 | |
FZD9 | GeneProduct | ncbigene:8326 | |
FZD2 | GeneProduct | ncbigene:2535 | |
DVL3 | GeneProduct | ncbigene:1857 | |
FRAT1 | GeneProduct | ncbigene:10023 | |
CSNK1E | GeneProduct | ncbigene:1454 | |
DVL2 | GeneProduct | ncbigene:1856 | |
DVL1 | GeneProduct | ncbigene:1855 | |
FRAT2 | GeneProduct | ensembl:ENSG00000181274 | |
TPTEP2-CSNK1E | GeneProduct | ncbigene:1454 | |
GSK3B | GeneProduct | ncbigene:2932 | MOUSE:KG38 MOUSE |
CSNK2B | GeneProduct | ensembl:ENSG00000204435 | |
CSNK2A1 | GeneProduct | ensembl:ENSG00000101266 | |
CSNK2A3 | GeneProduct | ensembl:ENSG00000254598 | |
CSNK2A2 | GeneProduct | ensembl:ENSG00000070770 | |
APC | GeneProduct | ncbigene:324 | |
CSNK1A1 | GeneProduct | ensembl:ENSG00000113712 | |
AXIN1 | GeneProduct | ncbigene:8312 | |
CSNK1A1L | GeneProduct | ensembl:ENSG00000180138 | |
AXIN2 | GeneProduct | ensembl:ENSG00000168646 | |
APC2 | GeneProduct | ensembl:ENSG00000115266 | |
CSNK1A1 | GeneProduct | ensembl:ENSG00000113712 | |
CSNK1A1L | GeneProduct | ensembl:ENSG00000180138 | |
CTNNB1 | GeneProduct | ncbigene:1499 | |
PPP3CA | GeneProduct | ensembl:ENSG00000138814 | |
PPP3CB | GeneProduct | ensembl:ENSG00000107758 | |
PPP3CC | GeneProduct | ensembl:ENSG00000120910 | |
PPP3R1 | GeneProduct | ensembl:ENSG00000221823 | |
PPP3R2 | GeneProduct | ensembl:ENSG00000188386 | |
GSK3B | GeneProduct | ncbigene:2932 | MOUSE:KG38 MOUSE |
sAPP alpha | GeneProduct | uniprot:P05067 | |
APP-C83 | GeneProduct | uniprot:P05067 | |
APP-C99 | GeneProduct | uniprot:P05067 | |
sAPP beta | GeneProduct | uniprot:P05067 | |
EIF2S1 | GeneProduct | ensembl:ENSG00000134001 | |
ATF4 | GeneProduct | ensembl:ENSG00000128272 | |
DDIT3 | GeneProduct | ensembl:ENSG00000175197 | |
TRAF2 | GeneProduct | ensembl:ENSG00000127191 | |
MAP3K5 | GeneProduct | ensembl:ENSG00000197442 | |
MAP2K7 | GeneProduct | ensembl:ENSG00000076984 | |
MAPK8 | GeneProduct | ensembl:ENSG00000107643 | |
MAPK10 | GeneProduct | ensembl:ENSG00000109339 | |
MAPK9 | GeneProduct | ensembl:ENSG00000050748 | |
XBP1 | GeneProduct | ensembl:ENSG00000100219 | |
DDIT3 | GeneProduct | ensembl:ENSG00000175197 | |
XBP1 | GeneProduct | ensembl:ENSG00000100219 | |
PSMA2 | GeneProduct | ncbigene:5683 | |
PSMB1 | GeneProduct | ncbigene:5689 | |
PSMA5 | GeneProduct | ncbigene:5686 | |
PSMB4 | GeneProduct | ncbigene:5692 | |
PSMB2 | GeneProduct | ncbigene:5690 | |
PSMA3 | GeneProduct | ncbigene:5684 | |
PSMA7 | GeneProduct | ncbigene:5688 | |
PSMA1 | GeneProduct | ncbigene:5682 | |
PSMB6 | GeneProduct | ncbigene:5694 | U13393 |
PSMA6 | GeneProduct | ncbigene:5687 | |
PSMB5 | GeneProduct | ncbigene:5693 | |
PSMA4 | GeneProduct | ncbigene:5685 | |
PSMB7 | GeneProduct | ncbigene:5695 | |
PSMB3 | GeneProduct | ncbigene:5691 | |
PSMA8 | GeneProduct | ensembl:ENSG00000154611 | |
PSMD8 | GeneProduct | ncbigene:5714 | |
SEM1 | GeneProduct | ensembl:ENSG00000127922 | |
PSMD1 | GeneProduct | ncbigene:5707 | |
PSMC6 | GeneProduct | ncbigene:5706 | |
PSMC5 | GeneProduct | ncbigene:5705 | |
PSMC4 | GeneProduct | ncbigene:5704 | |
PSMC3 | GeneProduct | ncbigene:5702 | |
PSMC2 | GeneProduct | ncbigene:5701 | |
PSMC1 | GeneProduct | ncbigene:5700 | |
PSMD7 | GeneProduct | ncbigene:5713 | |
PSMD6 | GeneProduct | ncbigene:9861 | |
ADRM1 | GeneProduct | ensembl:ENSG00000130706 | |
PSMD4 | GeneProduct | ncbigene:5710 | |
PSMD3 | GeneProduct | ncbigene:5709 | |
PSMD2 | GeneProduct | ncbigene:5708 | |
PSMD14 | GeneProduct | ncbigene:10213 | |
PSMD13 | GeneProduct | ncbigene:5719 | |
PSMD12 | GeneProduct | ncbigene:5718 | |
PSMD9 | GeneProduct | ncbigene:5715 | |
PPIF | GeneProduct | ensembl:ENSG00000108179 | |
SLC25A4 | GeneProduct | ensembl:ENSG00000151729 | |
SLC25A5 | GeneProduct | ensembl:ENSG00000005022 | |
SLC25A6 | GeneProduct | ensembl:ENSG00000169100 | |
VDAC1 | GeneProduct | ensembl:ENSG00000213585 | |
VDAC2 | GeneProduct | ensembl:ENSG00000165637 | |
VDAC3 | GeneProduct | ensembl:ENSG00000078668 | |
SLC25A31 | GeneProduct | ensembl:ENSG00000151475 | |
CALML4 | GeneProduct | ensembl:ENSG00000129007 | |
CALML6 | GeneProduct | ensembl:ENSG00000169885 | |
APH1B | GeneProduct | ensembl:ENSG00000138613 | |
MAP2K1 | GeneProduct | ncbigene:5604 | |
MAP2K2 | GeneProduct | ncbigene:5605 | |
MAPK1 | GeneProduct | ncbigene:5594 | |
MAPK3 | GeneProduct | ncbigene:5595 | |
PSEN1 | GeneProduct | ensembl:ENSG00000080815 | |
PSEN2 | GeneProduct | ensembl:ENSG00000143801 | |
RAGE | Protein | uniprot:Q15109 | |
NAC fragment | Protein | uniprot:P37840 |
References
- Hölscher C. Possible causes of Alzheimer’s disease: amyloid fragments, free radicals, and calcium homeostasis. Neurobiol Dis. 1998 Sep;5(3):129–41. PubMed Europe PMC Scholia
- Ivins KJ, Thornton PL, Rohn TT, Cotman CW. Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8. Neurobiol Dis. 1999 Oct;6(5):440–9. PubMed Europe PMC Scholia
- Lee MS, Kwon YT, Li M, Peng J, Friedlander RM, Tsai LH. Neurotoxicity induces cleavage of p35 to p25 by calpain. Nature. 2000 May 18;405(6784):360–4. PubMed Europe PMC Scholia
- Small DH, Mok SS, Bornstein JC. Alzheimer’s disease and Abeta toxicity: from top to bottom. Nat Rev Neurosci. 2001 Aug;2(8):595–8. PubMed Europe PMC Scholia
- Parihar MS, Hemnani T. Alzheimer’s disease pathogenesis and therapeutic interventions. J Clin Neurosci. 2004 Jun;11(5):456–67. PubMed Europe PMC Scholia
- Dickson DW. Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect? J Clin Invest. 2004 Jul;114(1):23–7. PubMed Europe PMC Scholia
- Mattson MP. Pathways towards and away from Alzheimer’s disease. Nature. 2004 Aug 5;430(7000):631–9. PubMed Europe PMC Scholia
- Katayama T, Imaizumi K, Manabe T, Hitomi J, Kudo T, Tohyama M. Induction of neuronal death by ER stress in Alzheimer’s disease. J Chem Neuroanat. 2004 Sep;28(1–2):67–78. PubMed Europe PMC Scholia
- Takuma K, Yan SS, Stern DM, Yamada K. Mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis in Alzheimer’s disease. J Pharmacol Sci. 2005 Mar;97(3):312–6. PubMed Europe PMC Scholia
- Gandy S. The role of cerebral amyloid beta accumulation in common forms of Alzheimer disease. J Clin Invest. 2005 May;115(5):1121–9. PubMed Europe PMC Scholia
- Avila J. Tau phosphorylation and aggregation in Alzheimer’s disease pathology. FEBS Lett. 2006 May 22;580(12):2922–7. PubMed Europe PMC Scholia
- Hauptmann S, Keil U, Scherping I, Bonert A, Eckert A, Müller WE. Mitochondrial dysfunction in sporadic and genetic Alzheimer’s disease. Exp Gerontol. 2006 Jul;41(7):668–73. PubMed Europe PMC Scholia
- Shen Y, He P, Zhong Z, McAllister C, Lindholm K. Distinct destructive signal pathways of neuronal death in Alzheimer’s disease. Trends Mol Med. 2006 Dec;12(12):574–9. PubMed Europe PMC Scholia
- Cowburn RF, Popescu BO, Ankarcrona M, Dehvari N, Cedazo-Minguez A. Presenilin-mediated signal transduction. Physiol Behav. 2007 Sep 10;92(1–2):93–7. PubMed Europe PMC Scholia
- Grimson A, Farh KK-H, Johnston WK, Garrett-Engele P, Lim LP, Bartel DP. MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol Cell. 2007 Jul 6;27(1):91–105. PubMed Europe PMC Scholia
- Bojarski L, Herms J, Kuznicki J. Calcium dysregulation in Alzheimer’s disease. Neurochem Int. 2008;52(4–5):621–33. PubMed Europe PMC Scholia
- Hébert SS, Horré K, Nicolaï L, Papadopoulou AS, Mandemakers W, Silahtaroglu AN, et al. Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer’s disease correlates with increased BACE1/beta-secretase expression. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6415–20. PubMed Europe PMC Scholia
- Bezprozvanny I, Mattson MP. Neuronal calcium mishandling and the pathogenesis of Alzheimer’s disease. Trends Neurosci. 2008 Sep;31(9):454–63. PubMed Europe PMC Scholia
- Reese LC, Zhang W, Dineley KT, Kayed R, Taglialatela G. Selective induction of calcineurin activity and signaling by oligomeric amyloid beta. Aging Cell. 2008 Dec;7(6):824–35. PubMed Europe PMC Scholia
- Papagiannakopoulos T, Shapiro A, Kosik KS. MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells. Cancer Res. 2008 Oct 1;68(19):8164–72. PubMed Europe PMC Scholia
- Zhou X, Ren Y, Moore L, Mei M, You Y, Xu P, et al. Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status. Lab Invest. 2010 Feb;90(2):144–55. PubMed Europe PMC Scholia
- Yang Z, Bian C, Zhou H, Huang S, Wang S, Liao L, et al. MicroRNA hsa-miR-138 inhibits adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells through adenovirus EID-1. Stem Cells Dev. 2011 Feb;20(2):259–67. PubMed Europe PMC Scholia
- Abdelmohsen K, Hutchison ER, Lee EK, Kuwano Y, Kim MM, Masuda K, et al. miR-375 inhibits differentiation of neurites by lowering HuD levels. Mol Cell Biol. 2010 Sep;30(17):4197–210. PubMed Europe PMC Scholia
- Terao M, Fratelli M, Kurosaki M, Zanetti A, Guarnaccia V, Paroni G, et al. Induction of miR-21 by retinoic acid in estrogen receptor-positive breast carcinoma cells: biological correlates and molecular targets. J Biol Chem. 2011 Feb 4;286(5):4027–42. PubMed Europe PMC Scholia
- Delay C, Mandemakers W, Hébert SS. MicroRNAs in Alzheimer’s disease. Neurobiol Dis. 2012 May;46(2):285–90. PubMed Europe PMC Scholia
- Chan XHD, Nama S, Gopal F, Rizk P, Ramasamy S, Sundaram G, et al. Targeting glioma stem cells by functional inhibition of a prosurvival oncomiR-138 in malignant gliomas. Cell Rep. 2012 Sep 27;2(3):591–602. PubMed Europe PMC Scholia
- Wu H, Huang M, Lu M, Zhu W, Shu Y, Cao P, et al. Regulation of microtubule-associated protein tau (MAPT) by miR-34c-5p determines the chemosensitivity of gastric cancer to paclitaxel. Cancer Chemother Pharmacol. 2013 May;71(5):1159–71. PubMed Europe PMC Scholia
- Burgos K, Malenica I, Metpally R, Courtright A, Rakela B, Beach T, et al. Profiles of extracellular miRNA in cerebrospinal fluid and serum from patients with Alzheimer’s and Parkinson’s diseases correlate with disease status and features of pathology. PLoS One. 2014 May 5;9(5):e94839. PubMed Europe PMC Scholia
- Piras S, Furfaro AL, Domenicotti C, Traverso N, Marinari UM, Pronzato MA, et al. RAGE Expression and ROS Generation in Neurons: Differentiation versus Damage. Oxid Med Cell Longev. 2016;2016:9348651. PubMed Europe PMC Scholia
- Vallée A, Lecarpentier Y. Alzheimer Disease: Crosstalk between the Canonical Wnt/Beta-Catenin Pathway and PPARs Alpha and Gamma. Front Neurosci. 2016 Oct 19;10:459. PubMed Europe PMC Scholia
- Wasser CR, Herz J. Reelin: Neurodevelopmental Architect and Homeostatic Regulator of Excitatory Synapses. J Biol Chem. 2017 Jan 27;292(4):1330–8. PubMed Europe PMC Scholia
- Lane-Donovan C, Herz J. ApoE, ApoE Receptors, and the Synapse in Alzheimer’s Disease. Trends Endocrinol Metab. 2017 Apr;28(4):273–84. PubMed Europe PMC Scholia
- Vargas LM, Cerpa W, Muñoz FJ, Zanlungo S, Alvarez AR. Amyloid-β oligomers synaptotoxicity: The emerging role of EphA4/c-Abl signaling in Alzheimer’s disease. Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt A):1148–59. PubMed Europe PMC Scholia
- Popugaeva E, Pchitskaya E, Bezprozvanny I. Dysregulation of Intracellular Calcium Signaling in Alzheimer’s Disease. Antioxid Redox Signal. 2018 Oct 20;29(12):1176–88. PubMed Europe PMC Scholia
- Strickland MR, Holtzman DM. Dr. Jekyll and Mr. Hyde: ApoE explains opposing effects of neuronal LRP1. J Clin Invest. 2019 Mar 1;129(3):969–71. PubMed Europe PMC Scholia
- Palomer E, Buechler J, Salinas PC. Wnt Signaling Deregulation in the Aging and Alzheimer’s Brain. Front Cell Neurosci. 2019 May 22;13:227. PubMed Europe PMC Scholia
- Sushma, Mondal AC. Role of GPCR signaling and calcium dysregulation in Alzheimer’s disease. Mol Cell Neurosci. 2019 Dec;101:103414. PubMed Europe PMC Scholia