Cholesterol is a waxy steroid metabolite found in the cell membranes and transported in the blood plasma of all animals. It is an essential structural component of mammalian cell membranes, where it is required to establish proper membrane permeability and fluidity. In addition, cholesterol is an important component for the manufacture of bile acids, steroid hormones, and several fat-soluble vitamins. Cholesterol is the principal sterol synthesized by animals, but small quantities are synthesized in other eukaryotes, such as plants and fungi. It is almost completely absent among prokaryotes, which include bacteria. Source: [[wikipedia:Cholesterol|Wikipedia]] Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP197 CPTAC Assay Portal]

Authors

Michael Lieberman , Patrick Ahles , Ned Mantei , Thomas Kelder , Samuel Sklar , Martijn Van Iersel , Egon Willighagen , Alex Pico , Bart Smeets , Daniel Riggins , Kristina Hanspers , Friederike Ehrhart , Denise Slenter , and Eric Weitz

Cited In

• 
• 
• 

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: cholesterol biosynthetic pathway

Participants

References

1. Porter FD. Malformation syndromes due to inborn errors of cholesterol synthesis. J Clin Invest. 2002 Sep;110(6):715–24. PubMed Europe PMC Scholia