DNA replication (WP192)

Caenorhabditis elegans

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: [[wikipedia:DNA_replication|Wikipedia]]
last edited


Kdahlquist , David Koren , Thomas Kelder , Egon Willighagen , Christine Chichester , Eric Weitz , Ulas Babayigit , Denise Slenter , and Lars Willighagen

Cited In

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Caenorhabditis elegans



Pathway Ontology: DNA replication pathway


Label Type Compact Identifier Comment
dATP Metabolite chebi:16284
ADP Metabolite chebi:16761
dCTP Metabolite chebi:16311
ATP Metabolite chebi:15422
CTP Metabolite chebi:17677
UTP Metabolite chebi:15713
ATP Metabolite chebi:15422
ATP Metabolite chebi:15422
dGTP Metabolite chebi:16497
ADP Metabolite chebi:16761
dUTP Metabolite chebi:17625
ATP Metabolite chebi:15422
GTP Metabolite chebi:15996
mcm-7 GeneProduct ncbigene:178831
rfc-1 GeneProduct ncbigene:179967
F10C2.4 GeneProduct ncbigene:179652
F33H2.5 GeneProduct ncbigene:173368
pri-1 GeneProduct ncbigene:176358
F34D10.2 GeneProduct ncbigene:175481
orc-2 GeneProduct ncbigene:174676
Y47D3A.28 GeneProduct ncbigene:176562
div-1 GeneProduct ncbigene:176439
pri-2 GeneProduct ncbigene:173122
mcm-2 GeneProduct ncbigene:174841
mcm-6 GeneProduct ncbigene:176385
rfc-3 GeneProduct ncbigene:178259
cdc-6 GeneProduct ncbigene:172029
Y39A1A.12 GeneProduct ncbigene:176486
Y47D3A.29 GeneProduct ncbigene:176544
ubq-1 GeneProduct ncbigene:175840
mcm-3 GeneProduct ncbigene:180010
F08B4.5 GeneProduct ncbigene:177673
ARPA GeneProduct ncbigene:176131
ubq-2 GeneProduct ncbigene:176718
CDC46 GeneProduct ncbigene:175552
rfc-2 GeneProduct ncbigene:176946
mcm-4 GeneProduct ncbigene:171793


  1. Rose A. Replication and repair. WormBook [Internet]. 2014 Dec 4;1–16. Available from: http://dx.doi.org/10.1895/wormbook.1.54.2 DOI
  2. Differential activation of the DNA replication checkpoint contributes to asynchrony of cell division in C. elegans embryos. Brauchle M, Baumer K, Gönczy P. Curr Biol. 2003 May 13;13(10):819–27. PubMed Europe PMC Scholia