Integrin-mediated cell adhesion (WP185)

Homo sapiens

Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and thereby define cellular shape, mobility, and regulate the cell cycle. Description reference: [[wikipedia:Integrins|Wikipedia]] Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP185 CPTAC Assay Portal]
last edited

Authors

Unknown , Martijn Van Iersel , Thomas Kelder , Kristina Hanspers , Alex Pico , Zahra Roudbari , Martina Summer-Kutmon , and Eric Weitz

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organism

Homo sapiens

Communities

CPTAC PancCanNet

Annotations

Pathway Ontology: integrin mediated signaling pathway

Participants

Label Type Compact Identifier Comment
CDC42 GeneProduct ncbigene:998 CDC42; cell division cycle 42 (GTP binding protein 25kD)
SHC1 GeneProduct ncbigene:6464 SHC1; SHC (Src homology 2 domain containing) transforming protein 1
SHC3 GeneProduct ncbigene:53358 SHC3; neuronal Sh
ARAF GeneProduct ncbigene:369 ARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-]
BRAF GeneProduct ncbigene:673 BRAF; v-raf murine sarcoma viral oncogene homolog B1 [EC:2.7.1.-]
RAF1 GeneProduct ncbigene:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
MAPK4 GeneProduct ncbigene:5596 MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]
MAPK7 GeneProduct ncbigene:5598 MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-
CAPNS1 GeneProduct ncbigene:826 CAPNS1; calpain small subunit 1 [EC:3.4.22.17]
MYLK2 GeneProduct ncbigene:85366 MYLK2; myosin light chain kinase 2 skeletal muscle [EC:2.7.1.117
ARHGEF7 GeneProduct ncbigene:8874 ARHGEF7; Rho guanine nucleotide exchange factor (GEF) 7
RAC1 GeneProduct ncbigene:5879 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1)
RAC2 GeneProduct ncbigene:5880 RAC2; ras-related C3 botulinum toxin substrate 2 (rho family small GTP binding protein Rac2)
RAC3 GeneProduct ncbigene:5881 RAC3; ras-related C3 botulinum toxin substrate 3 (rho family small GTP binding protein Rac3)
PDPK1 GeneProduct ncbigene:5170 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.1.37]
VAV2 GeneProduct ncbigene:7410 VAV2; vav 2 oncogene
VAV3 GeneProduct ncbigene:10451 VAV3; vav 3 oncogene
ROCK2 GeneProduct ncbigene:9475 ROCK2; Rho-associated coiled-coil containing protein kinase
ROCK1 GeneProduct ncbigene:6093 ROCK1; Rho-associated coiled-coil containing protein kinase
SORBS1 GeneProduct ncbigene:10580 SH3D5; SH3-domain protein 5 (ponsin
SOS1 GeneProduct ncbigene:6654 SOS1; son of sevenless homolog 1 (Drosophila)
GIT2 GeneProduct ncbigene:9815 GIT2; G protein-coupled receptor kinase-interactor 2
PIK3R2 GeneProduct ncbigene:5296 PIK3R2; phosphoinositide-3-kinase regulatory subunit polypeptide 2 (p85 beta)
ZYX GeneProduct ncbigene:7791 ZYX; zyxin
CAV1 GeneProduct ncbigene:857 CAV1; caveolin 1 caveolae protein 22kD
CAV2 GeneProduct ncbigene:858 CAV2; caveolin 2
CAV3 GeneProduct ncbigene:859 CAV3; caveolin 3
FYN GeneProduct ncbigene:2534 FYN; FYN oncogene related to SRC FGR YES [EC:2.7.1.112]
GRB2 GeneProduct ncbigene:2885 GRB2; growth factor receptor-bound protein 2
SEPP1 GeneProduct ncbigene:6414 SEPP1; selenoprotein P plasma
HRAS GeneProduct ncbigene:3265
PTK2 GeneProduct ncbigene:5747 PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112
PTK2 GeneProduct ncbigene:5747 PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112
RHO GeneProduct ncbigene:6010 RHO; rhodopsin (opsin 2 rod pigment) (retinitis pigmentosa 4 autosomal dominant)
CSK GeneProduct ncbigene:1445 CSK; c-src tyrosine kinase [EC:2.7.1.112]
BCAR1 GeneProduct ncbigene:9564 BCAR1; breast cancer anti-estrogen resistance 1
SRC GeneProduct ncbigene:6714 SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]
AKT1 GeneProduct ncbigene:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 [EC:2.7.1.-]
AKT2 GeneProduct ncbigene:208 AKT2; v-akt murine thymoma viral oncogene homolog 2 [EC:2.7.1.-]
MYO-P GeneProduct ensembl:ENSG00000138347
CAPN2 GeneProduct ncbigene:824 CAPN2; calpain 2 (m/II) large subunit [EC:3.4.22.17]
CAPN3 GeneProduct ncbigene:825 CAPN3; calpain 3 (p94) [EC:3.4.22.17]
CAPN5 GeneProduct ncbigene:726 CAPN5; calpain
CAPN7 GeneProduct ncbigene:23473 CAPN7; calpain 7 [EC:3.4.22.17
CAPN9 GeneProduct ncbigene:10753 CAPN9; calpain 9 (nCL-4) [EC:3.4.22.17
CAPN10 GeneProduct ncbigene:11132 CAPN10; calpain 10 [EC:3.4.22.17
CAPN11 GeneProduct ncbigene:11131 CAPN11; calpain 11 [EC:3.4.22.17]
CAPN6 GeneProduct ncbigene:827 CAPN6; calpain 6 [EC:3.4.22.17]
PAK2 GeneProduct ncbigene:5062 PAK2; p21 (CDKN1A)-activated kinase 2 [EC:2.7.1.-]
PAK3 GeneProduct ncbigene:5063 PAK3; p21 (CDKN1A)-activated kinase 3 [EC:2.7.1.-]
PAK4 GeneProduct ncbigene:10298 PAK4; p21(CDKN1A)-activated kinase 4 [EC:2.7.1.-]
PAK6 GeneProduct ncbigene:56924 PAK6; p21(CDKN1A)-activated kinase
TLN1 GeneProduct ncbigene:7094 TLN1; talin 1
MAP2K3 GeneProduct ncbigene:5606 MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]
MAP2K5 GeneProduct ncbigene:5607 MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]
MAP2K6 GeneProduct ncbigene:5608 MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-
MAPK12 GeneProduct ncbigene:6300 MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-]
AKT3 GeneProduct ncbigene:10000 AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) [EC:2.7.1.-]
DOCK1 GeneProduct ncbigene:1793 DOCK1; dedicator of cyto-kinesis
CRK GeneProduct ncbigene:1398 CRK; v-crk sarcoma virus CT10 oncogene homolog (avian
RAPGEF1 GeneProduct ncbigene:2889 GRF2; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene
RAP1A GeneProduct ncbigene:5906 RAP1A; RAP1A member of RAS oncogene family
RAP1B GeneProduct ncbigene:5908 RAP1B; RAP1B member of RAS oncogene family
MAPK1 GeneProduct ncbigene:5594 MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
MAPK6 GeneProduct ncbigene:5597 MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]
MAP2K1 GeneProduct ncbigene:5604 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
MAP2K2 GeneProduct ncbigene:5605 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]
CAPN1 GeneProduct ncbigene:823 CAPN1; calpain 1 (mu/I) large subunit [EC:3.4.22.17]
ITGA2 GeneProduct ncbigene:3673
ITGA3 GeneProduct ncbigene:3675
ITGA4 GeneProduct ncbigene:3676
ITGA5 GeneProduct ncbigene:3678
ITGA6 GeneProduct ncbigene:3655
ITGA8 GeneProduct ncbigene:8516
ITGA9 GeneProduct ncbigene:3680
ITGA10 GeneProduct ncbigene:8515
ITGA11 GeneProduct ncbigene:22801
ITGA2B GeneProduct ncbigene:3674
ITGAE GeneProduct ncbigene:3682
ITGAD GeneProduct ncbigene:3681
ITGAL GeneProduct ncbigene:3683
ITGAM GeneProduct ncbigene:3684
ITGAV GeneProduct ncbigene:3685
ITGAX GeneProduct ncbigene:3687
ITGB1 GeneProduct ncbigene:3688
ITGB2 GeneProduct ncbigene:3689
ITGB3 GeneProduct ncbigene:3690
ITGB4 GeneProduct ncbigene:3691
ITGB5 GeneProduct ncbigene:3693
ITGB6 GeneProduct ncbigene:3694
ITGB7 GeneProduct ncbigene:3695
ITGB8 GeneProduct ncbigene:3696
SRC GeneProduct ncbigene:6714 SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]
VCL GeneProduct ncbigene:7414 VCL; vinculin
TNS1 GeneProduct ncbigene:7145 TNS; tensi
MAPK10 GeneProduct ncbigene:5602
PXN GeneProduct ncbigene:5829 PXN; paxillin
ILK GeneProduct ncbigene:3611 ILK; integrin-linked kinase [EC:2.7.1.-]
PAK1 GeneProduct ncbigene:5058 PAK1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog yeast) [EC:2.7.1.-]
VASP GeneProduct ncbigene:7408 VASP; vasodilator-stimulated phosphoprotein
ITGA7 GeneProduct ncbigene:3679
ITGA1 GeneProduct ncbigene:3672
MIR34C GeneProduct ensembl:ENSG00000207562

References

  1. Sepulveda JL, Gkretsi V, Wu C. Assembly and signaling of adhesion complexes. Curr Top Dev Biol. 2005;68:183–225. PubMed Europe PMC Scholia
  2. Hermeking H. The miR-34 family in cancer and apoptosis. Cell Death Differ. 2010 Feb;17(2):193–9. PubMed Europe PMC Scholia