Kennedy pathway (WP1771)
Mus musculus
The CDP-choline pathway, first identified by Eugene Kennedy in 1956, is the predominant mechanism by which mammalian cells synthesize phosphatidylcholine (PC) for incorporation into membranes or lipid-derived signalling molecules. The CDP-choline pathway represents one half of what is known as the Kennedy pathway. The other half is the CDP-ethanolamine pathway which is responsible for the biosynthesis of the phospholipid product phosphatidylethanolamine (PE). Source: [https://en.wikipedia.org/wiki/CDP-choline_pathway Wikipedia]
Authors
Kristina Hanspers , Thomas Kelder , Daniela Digles , Egon Willighagen , Martina Summer-Kutmon , and Denise SlenterActivity
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Organisms
Mus musculusCommunities
Annotations
Pathway Ontology
phospholipid metabolic pathway CDP-choline pathway of phosphatidylcholine biosynthesis| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Ethanolamine | Metabolite | kegg.compound:C00189 | |
| SAM | Metabolite | kegg.compound:C00019 | |
| PPi | Metabolite | chebi:18361 | |
| Phosphocholine | Metabolite | chebi:18132 | |
| Sphingolipids | Metabolite | chebi:26739 | |
| Phosphatidylserine | Metabolite | kegg.compound:C02737 | |
| Phosphatidylethanolamine | Metabolite | kegg.compound:C00350 | |
| SAH | Metabolite | kegg.compound:C00021 | |
| CMP | Metabolite | chebi:17361 | |
| ATP | Metabolite | cas:1927-31-7 | |
| Phosphatidylcholines | Metabolite | cas:8002-43-5 | |
| Ethanolamine | Metabolite | kegg.compound:C00189 | |
| L-Serine | Metabolite | kegg.compound:C00065 | |
| ADP | Metabolite | cas:58-64-0 | |
| CDP-choline | Metabolite | kegg.compound:C00307 | |
| L-Serine | Metabolite | kegg.compound:C00065 | |
| Choline | Metabolite | kegg.compound:C00114 | |
| Choline | Metabolite | kegg.compound:C00114 | |
| O-Phosphoethanolamine | Metabolite | kegg.compound:C00346 | |
| AAG | Metabolite | chebi:73318 | |
| CDP-Ethanolamine | Metabolite | kegg.compound:C00570 | |
| CTP | Metabolite | cas:2056-98-6 | |
| Pisd | GeneProduct | ncbigene:320951 | |
| Cept1 | GeneProduct | ncbigene:99712 | |
| Pemt | GeneProduct | ncbigene:18618 | |
| Chkb | GeneProduct | ncbigene:12651 | |
| Sgpl1 | GeneProduct | ncbigene:20397 | |
| Ptdss1 | GeneProduct | ncbigene:19210 | |
| Chka | GeneProduct | ncbigene:12660 | |
| Pcyt1b | GeneProduct | ncbigene:236899 | |
| Pcyt2 | GeneProduct | ncbigene:68671 | |
| Etnk1 | GeneProduct | ncbigene:75320 | |
| Pcyt1a | GeneProduct | ncbigene:13026 | |
| Etnk2 | GeneProduct | ncbigene:214253 | |
| Chpt1 | GeneProduct | ncbigene:212862 | |
| Ptdss2 | GeneProduct | ncbigene:27388 |
References
- The Kennedy pathway--De novo synthesis of phosphatidylethanolamine and phosphatidylcholine. Gibellini F, Smith TK. IUBMB Life. 2010 Jun;62(6):414–28. PubMed Europe PMC Scholia