Folate metabolism (WP176)
Homo sapiens
The folic acid-centred micronutrient biological network. The most relevant biochemical processes related to folic acid in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the folic acid centred plasma metabolome. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP176 CPTAC Assay Portal]
Authors
Egoyenechea , Martijn Van Iersel , Thomas Kelder , Kristina Hanspers , Jill Dunham , Damariz Rivero , Jildau Bouwman , Alex Pico , Andra Waagmeester , Egon Willighagen , Martina Summer-Kutmon , Denise Slenter , Friederike Ehrhart , Youssef Walid , Eric Weitz , and Marvin MartensCited In
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Organism
Homo sapiensCommunities
MicronutrientsAnnotations
Pathway Ontology: folate metabolic pathway
Participants
Label | Type | Compact Identifier | Comment |
---|---|---|---|
PGE1 | Metabolite | hmdb:HMDB0001442 | Prostaglandin E1 |
F2-Isoprostane | Metabolite | wikidata:Q33659470 | |
F2-Isoprostane | Metabolite | wikidata:Q33659470 | |
8-Isoprostaglandin F2a | Metabolite | hmdb:HMDB0005083 | |
PGE1 | Metabolite | hmdb:HMDB0001442 | Prostaglandin E1 |
PGE2 | Metabolite | hmdb:HMDB0001220 | Prostaglandin E2 |
Thromboxane B2 | Metabolite | hmdb:HMDB0003252 | |
Thromboxane A2 | Metabolite | hmdb:HMDB0001452 | |
PGF2a | Metabolite | hmdb:HMDB0001139 | Prostaglandin F2a |
8-Isoprostaglandin F2a | Metabolite | hmdb:HMDB0005083 | |
PGF2a | Metabolite | hmdb:HMDB0001139 | Prostaglandin F2a |
PGE2 | Metabolite | hmdb:HMDB0001220 | Prostaglandin E2 |
Thromboxane B2 | Metabolite | hmdb:HMDB0003252 | |
NADP+ | Metabolite | hmdb:HMDB0000217 | Nicotinamide adenine dinucleotide phosphate-Oxidized |
NADP+ | Metabolite | hmdb:HMDB0000217 | Nicotinamide adenine dinucleotide phosphate-Oxidized |
NADP+ | Metabolite | hmdb:HMDB0000217 | Nicotinamide adenine dinucleotide phosphate-Oxidized |
NADP+ | Metabolite | hmdb:HMDB0000217 | Nicotinamide adenine dinucleotide phosphate-Oxidized |
NADP+ | Metabolite | hmdb:HMDB0000217 | Nicotinamide adenine dinucleotide phosphate-Oxidized |
NADP+ | Metabolite | hmdb:HMDB0000217 | Nicotinamide adenine dinucleotide phosphate-Oxidized |
NADP+ | Metabolite | hmdb:HMDB0000217 | Nicotinamide adenine dinucleotide phosphate-Oxidized |
Cysteine | Metabolite | hmdb:HMDB0000574 | |
Cysteine | Metabolite | hmdb:HMDB0000574 | |
H2O2 | Metabolite | hmdb:HMDB0003125 | Hydrogen peroxide |
5,10-Methylene-THF | Metabolite | hmdb:HMDB0001533 | 5,10-Methylenetetrahydrofolate |
5,10-Methenyl-THF | Metabolite | hmdb:HMDB0001354 | 5,10-Methenyltetrahydrofolic acid |
5-Formyl-THF | Metabolite | hmdb:HMDB0001562 | 5-Formyltetrahydrofolate |
10-Formyl-THF | Metabolite | hmdb:HMDB0000972 | 10-formyltetrahydrofolate |
GAR | Metabolite | hmdb:HMDB0002022 | glycinamide ribonucleotide |
FGAR | Metabolite | chebi:18272 | formylglycinamide ribonucleotide |
Dihydrofolate | Metabolite | hmdb:HMDB0001056 | |
5-methyl-THF | Metabolite | hmdb:HMDB0001396 | 5-methyltetrahydrofolatePredominant food folate |
Folate | Metabolite | chebi:37445 | Generic term used to denote both naturally occurring folate in foods (food folate) and the synthetic form of the vitamin (folic acid). |
Folate | Metabolite | chebi:37445 | Generic term used to denote both naturally occurring folate in foods (food folate) and the synthetic form of the vitamin (folic acid). |
5-methyl-THF | Metabolite | hmdb:HMDB0001396 | 5-methyltetrahydrofolatePredominant food folate |
H2O | Metabolite | hmdb:HMDB0002111 | Glutathione disulfide |
Heme | Metabolite | hmdb:HMDB0003178 | |
THF | Metabolite | hmdb:HMDB0001846 | Tetrahydrofolic acid |
NADPH | Metabolite | hmdb:HMDB0000221 | Nicotinamide adenine dinucleotide phosphate-Reduced |
NADPH | Metabolite | hmdb:HMDB0000221 | Nicotinamide adenine dinucleotide phosphate-Reduced |
NADPH | Metabolite | hmdb:HMDB0000221 | Nicotinamide adenine dinucleotide phosphate-Reduced |
NADPH | Metabolite | hmdb:HMDB0000221 | Nicotinamide adenine dinucleotide phosphate-Reduced |
NADPH | Metabolite | hmdb:HMDB0000221 | Nicotinamide adenine dinucleotide phosphate-Reduced |
NADPH | Metabolite | hmdb:HMDB0000221 | Nicotinamide adenine dinucleotide phosphate-Reduced |
NADPH | Metabolite | hmdb:HMDB0000221 | Nicotinamide adenine dinucleotide phosphate-Reduced |
Manganese | Metabolite | hmdb:HMDB0001333 | |
Manganese | Metabolite | hmdb:HMDB0001333 | |
Folic acid | Metabolite | hmdb:HMDB0000121 | Synthetic folate |
Folic acid | Metabolite | hmdb:HMDB0000121 | Synthetic folate |
RNS | Metabolite | chebi:62764 | reactive nitrogen specieshttp://en.wikipedia.org/wiki/Reactive_nitrogen_species |
Homocysteine | Metabolite | hmdb:HMDB0000742 | |
Homocysteine | Metabolite | hmdb:HMDB0000742 | |
Pyridoxal 5'-phosphate | Metabolite | hmdb:HMDB0001491 | |
Pyridoxal 5'-phosphate | Metabolite | hmdb:HMDB0001491 | Vitamin B6 |
Glycine | Metabolite | hmdb:HMDB0000123 | |
Glycine | Metabolite | hmdb:HMDB0000123 | |
L-Arginine | Metabolite | hmdb:HMDB0000517 | |
Serine | Metabolite | hmdb:HMDB0000187 | |
LDL | Metabolite | chebi:39026 | low-density lipoprotein |
HDL/APOA1 | Metabolite | chebi:39025 | high-density lipoproteinApoA-I is present on the majority of HDL particles and constitutes aprox 70% of the apolipoprotein content of HDL particles |
LDL | Metabolite | chebi:39026 | low-density lipoprotein |
TAG | Metabolite | chebi:17855 | TriglycerideTriacylglycerol |
Cholesterol | Metabolite | hmdb:HMDB0000067 | |
HDL/SAA | Metabolite | chebi:39025 | high-density lipoproteinSAA circulates in plasma as a constituent of high density lipoproteins (HDL). |
HDL | Metabolite | chebi:39025 | high-density lipoprotein |
oxLDL | Metabolite | chebi:60151 | oxidized low-density lipoprotein |
TAG | Metabolite | chebi:17855 | TriglycerideTriacylglycerol |
VLDL | Metabolite | chebi:39027 | very-low-density lipoprotein |
FMN | Metabolite | hmdb:HMDB0001520 | Flavin Mononucleotide |
HDL | Metabolite | chebi:39025 | high-density lipoprotein |
HDL-C | Metabolite | chebi:47775 | high-density lipoprotein cholesterolCholesterol transport |
HDL-C | Metabolite | chebi:47775 | high-density lipoprotein cholesterolCholesterol transport |
VLDL | Metabolite | chebi:39027 | very-low-density lipoprotein |
VLDL-TAG | Metabolite | chebi:47776 | very-low-density lipoprotein-triglycerideTriglyceride transport |
oxLDL | Metabolite | chebi:60151 | oxidized low-density lipoprotein |
Cholesterol | Metabolite | hmdb:HMDB0000067 | |
VLDL/APOB | Metabolite | chebi:39027 | very-low-density lipoproteinThe VLDL is produced in the liver, contains one molecule of apoB100 |
VLDL-TAG | Metabolite | chebi:47776 | very-low-density lipoprotein-triglycerideTriglyceride transport |
O2 | Metabolite | hmdb:HMDB0001377 | |
Cob(I)alamin | Metabolite | hmdb:HMDB0002174 | Reduced cobalamin |
FAD | Metabolite | hmdb:HMDB0001248 | Flavin adenine dinucleotide |
Cob(I)alamin | Metabolite | hmdb:HMDB0002174 | Reduced cobalamin |
8-OHdG | Metabolite | hmdb:HMDB0003333 | 8-Hydroxy-deoxyguanosine |
FAD | Metabolite | hmdb:HMDB0001248 | Flavin adenine dinucleotide |
Cob(II)alamin | Metabolite | hmdb:HMDB0002174 | oxidized cobalamin |
8-OHdG | Metabolite | hmdb:HMDB0003333 | 8-Hydroxy-deoxyguanosine |
ADP | Metabolite | hmdb:HMDB0001341 | Adenosine diphosphate |
ADP | Metabolite | hmdb:HMDB0001341 | Adenosine diphosphate |
Magnesium | Metabolite | hmdb:HMDB0000547 | |
Chlorine | Metabolite | hmdb:HMDB0000492 | |
Chlorine | Metabolite | hmdb:HMDB0000492 | |
Magnesium | Metabolite | hmdb:HMDB0000547 | |
S-nitrosohomocysteine | Metabolite | pubchem.compound:3035701 | |
Cystathionine | Metabolite | hmdb:HMDB0000099 | |
Serine | Metabolite | hmdb:HMDB0000187 | |
ATP | Metabolite | hmdb:HMDB0000538 | Adenosine triphosphate |
Zinc | Metabolite | hmdb:HMDB0015532 | |
Zinc | Metabolite | hmdb:HMDB0015532 | |
NO | Metabolite | hmdb:HMDB0003378 | Nitric oxide |
HOCl | Metabolite | hmdb:HMDB0001050 | Hypochlorite |
NO | Metabolite | hmdb:HMDB0003378 | Nitric oxide |
O3 | Metabolite | chebi:25812 | ozone |
NO2 | Metabolite | chebi:33101 | Nitrogen dioxide |
HNO2 | Metabolite | chebi:25567 | Nitrous acid |
Fibrin | Metabolite | wikidata:Q27205 | |
Riboflavin | Metabolite | hmdb:HMDB0000244 | |
O2 | Metabolite | hmdb:HMDB0002168 | Superoxide |
S-Adenosylmethionine | Metabolite | hmdb:HMDB0001185 | |
Methionine | Metabolite | hmdb:HMDB0000696 | |
S-Adenosylhomocysteine | Metabolite | hmdb:HMDB0000939 | |
Methionine | Metabolite | hmdb:HMDB0000696 | |
S-Adenosylmethionine | Metabolite | hmdb:HMDB0001185 | |
S-Adenosylhomocysteine | Metabolite | hmdb:HMDB0000939 | |
ADP | Metabolite | hmdb:HMDB0001341 | Adenosine diphosphate |
ONOO/ONOOH | Metabolite | hmdb:HMDB0002179 | Peroxynitrite |
Nitrotyrosine | Metabolite | hmdb:HMDB0001904 | |
Nitrotyrosine | Metabolite | hmdb:HMDB0001904 | |
Tetrahydrobiopterin | Metabolite | hmdb:HMDB0000027 | H4B |
ATP | Metabolite | hmdb:HMDB0000538 | Adenosine triphosphate |
ATP | Metabolite | hmdb:HMDB0000538 | Adenosine triphosphate |
Glucose | Metabolite | hmdb:HMDB0000122 | |
Glucose | Metabolite | hmdb:HMDB0000122 | |
Fructosamine | Metabolite | hmdb:HMDB0002030 | |
Fructosamine | Metabolite | hmdb:HMDB0002030 | |
Iron | Metabolite | hmdb:HMDB0000692 | |
Iron | Metabolite | hmdb:HMDB0000692 | |
NFKB1 | GeneProduct | ncbigene:4790 | nuclear factor NF-kappa-B p50 subunit |
FOLR1 | GeneProduct | ncbigene:2348 | folate receptor 1 (adult) |
RELA | GeneProduct | ncbigene:5970 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 |
MCP1 | GeneProduct | ncbigene:6347 | Monocyte Chemotactic Protein 1CCL2 |
MCP1 | GeneProduct | ncbigene:6347 | Monocyte Chemotactic Protein 1CCL2 |
p53 | GeneProduct | ncbigene:7157 | tumor protein p53 |
FOLR4 | GeneProduct | ncbigene:390243 | folate receptor 4 (delta) homolog (mouse) |
FOLR3 | GeneProduct | ncbigene:2352 | folate receptor 3 (gamma) |
SLC19A1 | GeneProduct | ncbigene:6573 | solute carrier family 19 (folate transporter), member 1 |
NFKB2 | GeneProduct | ncbigene:4791 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 |
FOLR2 | GeneProduct | ncbigene:2350 | folate receptor 2 (fetal) |
SLC46A1 | GeneProduct | ncbigene:113235 | solute carrier family 46 (folate transporter), member 1 |
MTHFD2 | Protein | ncbigene:10797 | EC 3.5.4.9methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase |
MSR* | Protein | ncbigene:4552 | EC 1.16.1.85-methyltetrahydrofolate-homocysteine methyltransferase reductase |
MAT | Protein | ncbigene:4143 | EC 2.5.1.6Methionine adenosyltransferase |
MTHFD1* | Protein | ncbigene:4522 | EC 1.5.1.5methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 |
MTR* | Protein | ncbigene:4548 | EC 2.1.1.135-methyltetrahydrofolate-homocysteine methyltransferaseAlso known as MS |
AHCY | Protein | ncbigene:191 | EC 3.3.1.1Adenosylhomocysteinase |
SHMT | Protein | ncbigene:6472 | EC 2.1.2.1Serine hydroxymethyltransferase |
DHFR | Protein | ncbigene:1719 | EC 1.5.1.3Dihydrofolate reductase |
CBS | Protein | ncbigene:875 | EC 4.2.1.22cystathionine-beta-synthase |
MPO | Protein | ncbigene:4353 | EC 1.11.1.7Myeloperoxidase |
NOS | Protein | uniprot:C9J5P6 | Nitric oxide synthase |
Catalase | Protein | ncbigene:847 | EC 1.11.1.6 |
MPO | Protein | ncbigene:4353 | EC 1.11.1.7Myeloperoxidase |
tPA | Protein | ncbigene:5327 | EC 3.4.21.68plasminogen activator, tissue |
Factor VII | Protein | ncbigene:2155 | EC 3.4.21.21coagulation factor VII (serum prothrombin conversion accelerator) |
PLG | Protein | ncbigene:5340 | EC 3.4.21.7Plasminogen |
tPA | Protein | ncbigene:5327 | EC 3.4.21.68plasminogen activator, tissue |
Thrombin | Protein | ncbigene:2147 | EC 3.4.21.5coagulation factor II (thrombin) |
Thrombin | Protein | ncbigene:2147 | EC 3.4.21.5coagulation factor II (thrombin) |
PAI-1 | Protein | ncbigene:5054 | Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
Factor VII | Protein | ncbigene:2155 | EC 3.4.21.21coagulation factor VII (serum prothrombin conversion accelerator) |
PAI-1 | Protein | ncbigene:5054 | Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
PLG | Protein | ncbigene:5340 | EC 3.4.21.7Plasminogen |
GPX 4 | Protein | ncbigene:2879 | EC 1.11.1.12Selenoprotein-glutathione peroxidase 4 |
SOD3 | Protein | ncbigene:6649 | EC 1.15.1.1superoxide dismutase 3, extracellular |
SOD3 | Protein | ncbigene:6649 | EC 1.15.1.1superoxide dismutase 3, extracellular |
RFK | Protein | ncbigene:55312 | EC 2.7.1.26riboflavin kinase |
GPX 3 | Protein | ncbigene:2878 | EC 1.11.1.9Selenoprotein-glutathione peroxidase 3 |
GPX 3 | Protein | ncbigene:2878 | EC 1.11.1.9Selenoprotein-glutathione peroxidase 3 |
CTH | Protein | ncbigene:1491 | EC 4.4.1.1cystathionase |
GPX 6 | Protein | ncbigene:257202 | EC 1.11.1.9Selenoprotein-glutathione peroxidase 6 |
GPX 2 | Protein | ncbigene:2877 | EC 1.11.1.9Selenoprotein-glutathione peroxidase 2 |
GPX 1 | Protein | ncbigene:2876 | EC 1.11.1.9Selenoprotein-glutathione peroxidase 1 |
MTHFR* | Protein | ncbigene:4524 | EC 1.5.1.205,10-methylenetetrahydrofolate reductaseHomozygous of (MTHFR) 677C-T variant may have enzyme activities up to 50% lower than those without the polymorphism increasing the risk of hyperhomocysteinemia |
GART | Protein | ncbigene:2618 | EC 2.1.2.2phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase |
MTHFS | Protein | ncbigene:10588 | EC 6.3.3.25,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) |
SHMT | Protein | ncbigene:6470 | EC 2.1.2.1Serine hydroxymethyltransferase 1 (soluble) |
SOD1 | Protein | ncbigene:6647 | EC 1.15.1.1superoxide dismutase 1, soluble |
ACT | Protein | ncbigene:12 | alpha-1-antichymotrypsinserpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 |
APOB | Protein | ncbigene:338 | apolipoprotein B |
APOA1 | Protein | ncbigene:335 | apolipoprotein A-I |
APOA1 | Protein | ncbigene:335 | apolipoprotein A-I |
APOB | Protein | ncbigene:338 | apolipoprotein B |
SAA1 | Protein | ncbigene:6288 | serum amyloid A1 |
ABCA1 | Protein | ncbigene:19 | ATP-binding cassette, sub-family A (ABC1), member 1 |
SAA4 | Protein | ncbigene:6291 | serum amyloid A4, constitutive |
SAA2 | Protein | ncbigene:6289 | serum amyloid A2 |
SRB1 | Protein | ncbigene:949 | scavenger receptor class B, member 1 |
SAA3 | Protein | ncbigene:6290 | serum amyloid A3 pseudogene |
APOA1-NO2Tyr | Protein | ncbigene:335 | Nitrotyrosinated apolipoprotein A-I |
ACT | Protein | ncbigene:12 | alpha-1-antichymotrypsinserpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 |
LDLR | Protein | ncbigene:3949 | low density lipoprotein receptor |
SOD2 | Protein | ncbigene:6648 | EC 1.15.1.1superoxide dismutase 2, mitochondrial |
IL1B | Protein | ncbigene:3553 | interleukin 1, beta |
IL2 | Protein | ncbigene:3558 | interleukin 2 |
Fibrinogen | Protein | wikidata:Q381899 | |
IL1B | Protein | ncbigene:3553 | interleukin 1, beta |
CRP | Protein | ncbigene:1401 | C-reactive protein, pentraxin-related |
HBB | Protein | ncbigene:3043 | hemoglobin, beta |
INSR | Protein | ncbigene:3643 | Insulin receptor |
HBA1 | Protein | ncbigene:3039 | hemoglobin, alpha 1 |
Fibrin | Protein | wikidata:Q27205 | |
IL10 | Protein | ncbigene:3458 | interferon, gamma |
HbA1c | Protein | wikidata:Q311213 | Glycated hemoglobinhttp://en.wikipedia.org/wiki/Glycated_hemoglobin |
IL2 | Protein | ncbigene:3558 | interleukin 2 |
IL4 | Protein | ncbigene:3565 | interleukin 4 |
CSF1 | Protein | ncbigene:1435 | colony stimulating factor 1 (macrophage) |
ALB | Protein | ncbigene:213 | albumin |
D-dimer | Protein | wikidata:Q2162109 | http://en.wikipedia.org/wiki/Fibrin_degradation_product |
INS | Protein | ncbigene:3630 | Insulin |
IFNg | Protein | ncbigene:3458 | interferon, gamma |
Fibrinogen | Protein | wikidata:Q381899 | |
sICAM-1 | Protein | ncbigene:3383 | soluble intercellular adhesion molecule 1 |
IL10 | Protein | ncbigene:3458 | interferon, gamma |
IL4 | Protein | ncbigene:3565 | interleukin 4 |
IFNg | Protein | ncbigene:3458 | interferon, gamma |
TNFa | Protein | ncbigene:7124 | tumor necrosis factor (TNF superfamily, member 2) |
TNFa | Protein | ncbigene:7124 | tumor necrosis factor (TNF superfamily, member 2) |
D-dimer | Protein | wikidata:Q2162109 | http://en.wikipedia.org/wiki/Fibrin_degradation_product |
CSF1 | Protein | ncbigene:1435 | colony stimulating factor 1 (macrophage) |
IL6 | Protein | ncbigene:3569 | interleukin 6 (interferon, beta 2) |
INS | Protein | ncbigene:3630 | Insulin |
ALB | Protein | ncbigene:213 | albumin |
IL6 | Protein | ncbigene:3569 | interleukin 6 (interferon, beta 2) |
FLAD1 | Protein | ncbigene:80308 | EC 2.7.7.2FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae) |
FGA | Protein | ensembl:ENSG00000171560 | |
FGB | Protein | ensembl:ENSG00000171564 | |
FGG | Protein | ensembl:ENSG00000171557 |
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