Statin pathway (WP145)

Rattus norvegicus

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What are statins? See Wikipedia at: http://en.wikipedia.org/wiki/Statin More about this pathway and statins: https://www.pharmgkb.org/do/serve?objId=PA2031&objCls=Pathway

Authors

Nathan Salomonis , Kristina Hanspers , Bruce Conklin , Thomas Kelder , Alex Pico , Daniela Digles , Egon Willighagen , Lauren J. Dupuis , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Rattus norvegicus

Communities

Annotations

Pathway Ontology

statin drug pathway

Cell Type Ontology

hepatocyte

Participants

Label Type Compact URI Comment
Cholesterol Metabolite chebi:16113
Cholic Acid Metabolite chebi:16359
acetylCoA Metabolite chebi:15351
Phospholipid Metabolite chebi:16247
Cholesterol Ester Metabolite chebi:17002
Triglycerides Metabolite chebi:17855
Cholesterol Metabolite chebi:16113
LDL Metabolite chebi:39026
HDL Metabolite chebi:39025
Free FA Metabolite chebi:35366
Lipc GeneProduct ncbigene:24538
Lcat GeneProduct ncbigene:24530
Apoe GeneProduct ncbigene:25728
Lpl GeneProduct ncbigene:24539
Apoc1 GeneProduct ncbigene:25292
Apoc3 GeneProduct ncbigene:24207
Scarb1 GeneProduct ncbigene:25073
Dgat1 GeneProduct ncbigene:84497
Ldlr GeneProduct ncbigene:300438
Mttp GeneProduct ncbigene:310900
Apoa1 GeneProduct ncbigene:25081
Apoc2 GeneProduct ncbigene:25384
Hmgcr GeneProduct ncbigene:25675
Lrp1 GeneProduct ncbigene:299858
Apoa4 GeneProduct ncbigene:25080
Ptlp GeneProduct ncbigene:296371
Abca1 GeneProduct ncbigene:313210
Cyp7a1 GeneProduct ncbigene:25428
Soat1 GeneProduct ncbigene:81782

References

  1. Direct effects of statins on cells primarily involved in atherosclerosis. Chen H, Ikeda U, Shimpo M, Shimada K. Hypertens Res. 2000 Mar;23(2):187–92. PubMed Europe PMC Scholia