Cell cycle (WP1393)
Danio rerio
(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a cell, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. Two key classes of regulatory molecules, cyclins and cyclin-dependent kinases (CDKs), determine a cell's progress through the cell cycle.
Authors
Martijn Van Iersel , Martina Summer-Kutmon , Levi Wackers , and Lauren J. DupuisCited In
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Organism
Danio rerioCommunities
Annotations
Pathway Ontology: cell cycle pathway
Participants
| Label | Type | Compact Identifier | Comment |
|---|---|---|---|
| pttg1 | GeneProduct | ensembl:ENSDARG00000075421 | PTTG1; pituitary tumor-transforming |
| cdkn2a/b | GeneProduct | ensembl:ENSDARG00000037262 | |
| ywhag1 | GeneProduct | ensembl:ENSDARG00000067626 | YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptid |
| cdk6 | GeneProduct | ncbigene:100034507 | CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-] |
| ccna2 | GeneProduct | ncbigene:192295 | CCNA2; cyclin A2 |
| cdc20 | GeneProduct | ncbigene:406353 | CDC20; CDC20 cell division cycle 20 homolog (S. cerevisiae |
| MPEG1 | GeneProduct | ncbigene:335407 | |
| ccne2 | GeneProduct | ncbigene:415165 | CCNE2; cyclin E |
| cdc25 | GeneProduct | ncbigene:57925 | CDC25B; cell division cycle 25B [EC:3.1.3.48] |
| zgc:85772 | GeneProduct | ncbigene:406462 | ORC4L; origin recognition complex subunit 4-like (yeast) |
| rb1 | GeneProduct | ncbigene:777733 | RB1; retinoblastoma 1 (including osteosarcoma) |
| tbc1d8 | GeneProduct | ensembl:ENSDARG00000104493 | |
| hdac4 | GeneProduct | ncbigene:568877 | HDAC4; histone deacetylase 4 |
| ccnd2a | GeneProduct | ncbigene:799608 | CCND2; cyclin D2 |
| wu:fa96e12 | GeneProduct | ncbigene:562283 | PRKDC; protein kinase DNA-activated catalytic polypeptide [EC:2.7.1.37] |
| smc1a | GeneProduct | ncbigene:559665 | SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast |
| ep300a | GeneProduct | ncbigene:559273 | EP300; E1A binding protein p300 |
| orc3 | GeneProduct | ncbigene:334315 | ORC3L; origin recognition complex subunit 3-like (yeast) |
| bub3 | GeneProduct | ncbigene:403012 | BUB3; BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) |
| chek2 | GeneProduct | ncbigene:336998 | CHEK2; CHK2 checkpoint homolog (S. pombe) [EC:2.7.1.-] |
| HDAC7A | GeneProduct | ensembl:ENSDARG00000105179 | HDAC7A; histone deacetylase 7 |
| rb1 | GeneProduct | ncbigene:777733 | RB1; retinoblastoma 1 (including osteosarcoma) |
| MEN | GeneProduct | ensembl:ENSDARG00000000568 | |
| mdm2 | GeneProduct | ncbigene:30637 | MDM2; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) |
| mcm7 | GeneProduct | ensembl:ENSDARG00000101180 | MCM7; MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) |
| DKEY-168J9.1 | GeneProduct | ncbigene:565969 | CDC14A; CDC14 cell division cycle 14 homolog A (S. cerevisiae |
| hdac8 | GeneProduct | ncbigene:406740 | HDAC8; histone deacetylase |
| ccnh | GeneProduct | ncbigene:541325 | CCNH; cyclin H |
| espl1 | GeneProduct | ncbigene:797406 | ESPL1; extra spindle poles like 1 (S. cerevisiae |
| hdac1 | GeneProduct | ncbigene:192302 | HDAC1; histone deacetylase 1 |
| cdkn1b | GeneProduct | ncbigene:368329 | CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1) |
| rbl1 | GeneProduct | ncbigene:795522 | |
| mad2l1 | GeneProduct | ncbigene:550434 | MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast) |
| ccnb2 | GeneProduct | ncbigene:368316 | CCNB2; cyclin B2 |
| cdk2 | GeneProduct | ncbigene:406715 | CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-] |
| LOC557486 | GeneProduct | ncbigene:557486 | HDAC5; histone deacetylase 5 |
| UBE2F | GeneProduct | ensembl:ENSDARG00000025754 | UBE2F; ubiquitin-conjugating enzyme E2F (UBC6 homolog C. elegans |
| bub1bb | GeneProduct | ncbigene:567006 | BUB1B; BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) [EC:2.7.1.-] |
| orc1 | GeneProduct | ncbigene:554509 | ORC1L; origin recognition complex subunit 1-like (yeast) |
| hdac6 | GeneProduct | ncbigene:565482 | HDAC6; histone deacetylase 6 |
| mad1l1 | GeneProduct | ncbigene:393886 | MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast |
| smad3b | GeneProduct | ncbigene:326283 | MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila) |
| cdc45l | GeneProduct | ncbigene:406695 | CDC45L; CDC45 cell division cycle 45-like (S. cerevisiae) |
| ccne | GeneProduct | ncbigene:30188 | CCNE1; cyclin E |
| zgc:153369 | GeneProduct | ncbigene:767751 | CCNB3; cyclin B |
| ccna2 | GeneProduct | ncbigene:192295 | CCNA2; cyclin A2 |
| tfdp1a | GeneProduct | ncbigene:406813 | TFDP1; transcription factor Dp-1 |
| e2f3 | GeneProduct | ensembl:ENSDARG00000070463 | E2F3; E2F transcription factor 3 |
| wee1 | GeneProduct | ncbigene:327060 | WEE1; WEE1+ homolog (S. pombe) [EC:2.7.1.112] |
| cdk2 | GeneProduct | ncbigene:406715 | CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-] |
| CDH1 | GeneProduct | ncbigene:114424 | |
| CCND3 | GeneProduct | ensembl:ENSDARG00000027391 | CCND3; cyclin D3 |
| TGFB1 | GeneProduct | ncbigene:359834 | |
| rbl1 | GeneProduct | ncbigene:795522 | RBL1; retinoblastoma-like 1 (p107) |
| cdk4 | GeneProduct | ncbigene:777730 | CDK4; cyclin-dependent kinase 4 [EC:2.7.1.-] |
| kitlgb | GeneProduct | ensembl:ENSDARG00000058042 | |
| cdc25b | GeneProduct | ensembl:ENSDARG00000010792 | CDC25A; cell division cycle 25A [EC:3.1.3.48]cdc25b is zebrafish ortholog of human CDC25A |
| tp53 | GeneProduct | ncbigene:30590 | |
| atm | GeneProduct | ensembl:ENSDARG00000002385 | ATM; ataxia telangiectasia mutated (includes complementation groups A C and D) [EC:2.7.1.37] |
| abl1 | GeneProduct | ncbigene:100000720 | ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1 [EC:2.7.1.112 |
| zgc:174506 | GeneProduct | ncbigene:402825 | CDC6; CDC6 cell division cycle 6 homolog (S. cerevisiae |
| skp2 | GeneProduct | ncbigene:563708 | SKP2; S-phase kinase-associated protein 2 (p45 |
| ccna1 | GeneProduct | ncbigene:404206 | CCNA1; cyclin A1 |
| LOC559111 | GeneProduct | ncbigene:559111 | MADH4; MAD mothers against decapentaplegic homolog 4 (Drosophila) |
| ccnb1 | GeneProduct | ncbigene:58025 | CCNB1; cyclin B1 |
| CDKN1A | GeneProduct | ncbigene:100151416 | |
| cdk2 | GeneProduct | ncbigene:406715 | CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-] |
| e2f1 | GeneProduct | ensembl:ENSDARG00000103868 | E2F1; E2F transcription factor 1 |
| atr | GeneProduct | ensembl:ENSDARG00000079625 | ATR; ataxia telangiectasia and Rad3 related |
| e2f4 | GeneProduct | ncbigene:406741 | E2F4; E2F transcription factor 4 p107/p130-binding |
| hdac3 | GeneProduct | ncbigene:393965 | HDAC3; histone deacetylase 3 |
| mcm6 | GeneProduct | ncbigene:566409 | MCM6; MCM6 minichromosome maintenance deficient 6 (MIS5 homolog S. pombe) (S. cerevisiae) |
| chek1 | GeneProduct | ncbigene:393162 | CHEK1; CHK1 checkpoint homolog (S. pombe) [EC:2.7.1.-] |
| mcm4 | GeneProduct | ncbigene:337598 | MCM4; MCM4 minichromosome maintenance deficient 4 (S. cerevisiae |
| ccna1 | GeneProduct | ncbigene:404206 | CCNA1; cyclin A1 |
| bub1 | GeneProduct | ensembl:ENSDARG00000077029 | BUB1; BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) [EC:2.7.1.-] |
| rb1 | GeneProduct | ncbigene:777733 | RB1; retinoblastoma 1 (including osteosarcoma) |
| orc5 | GeneProduct | ncbigene:406479 | ORC5L; origin recognition complex subunit 5-like (yeast) |
| zgc:163016 | GeneProduct | ncbigene:100049158 | PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinas |
| mcm2 | GeneProduct | ncbigene:192338 | MCM2; MCM2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae |
| mad2l2 | GeneProduct | ensembl:ENSDARG00000042456 | MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast) |
| e2f2 | GeneProduct | ensembl:ENSDARG00000079233 | E2F2; E2F transcription factor 2 |
| cdc2 | GeneProduct | ncbigene:80973 | CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.- |
| plk1 | GeneProduct | ncbigene:280649 | PLK; polo-like kinase (Drosophila) [EC:2.7.1.-] |
| orc2 | GeneProduct | ensembl:ENSDARG00000101465 | ORC2L; origin recognition complex subunit 2-like (yeast) |
| mcm5 | GeneProduct | ncbigene:286747 | MCM5; MCM5 minichromosome maintenance deficient 5 cell division cycle 46 (S. cerevisiae) |
| gsk3b | GeneProduct | ncbigene:30654 | GSK3B; glycogen synthase kinase 3 beta [EC:2.7.1.37] |
| cdc2 | GeneProduct | ncbigene:80973 | CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.- |
| GADD45A | GeneProduct | ncbigene:431763 | |
| orc6l | GeneProduct | ncbigene:324256 | ORC6L; origin recognition complex subunit 6-like (yeast) |
| mcm3 | GeneProduct | ncbigene:192323 | MCM3; MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) |
| zgc:101602 | GeneProduct | ncbigene:492768 | CDC7L1; CDC7 cell division cycle 7-like 1 (S. cerevisiae) [EC:2.7.1.-] |
| cdc14b | GeneProduct | ncbigene:393148 | CDC14B; CDC14 cell division cycle 14 homolog B (S. cerevisiae |
| si:ch211-195d17.2 | GeneProduct | ncbigene:560495 | E2F6; E2F transcription factor 6 |
| pcna | GeneProduct | ncbigene:30678 | PCNA; proliferating cell nuclear antigen |
| e2f5 | GeneProduct | ncbigene:402908 | E2F5; E2F transcription factor 5 p130-binding |
| kitlga | GeneProduct | ensembl:ENSDARG00000070917 | |
| kitlgb | GeneProduct | ensembl:ENSDARG00000058042 | |
| skp2 | GeneProduct | ncbigene:563708 | SKP2; S-phase kinase-associated protein 2 (p45 |
| kitlga | GeneProduct | ensembl:ENSDARG00000070917 | |
| ywhag2 | GeneProduct | ensembl:ENSDARG00000071658 | YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptid |
References
- Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, et al. Science. 1998 Sep 11;281(5383):1677–9. PubMed Europe PMC Scholia