Phase I biotransformations, non P450 (WP136)
Homo sapiens
This pathway lists several phase 1 biotransformations and their related enzymes. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP136 CPTAC Assay Portal]
Authors
Rollie , Thomas Kelder , Chris Evelo , Kristina Hanspers , Egon Willighagen , Zahra Roudbari , Martina Summer-Kutmon , and Marvin MartensCited In
Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.
Organism
Homo sapiensCommunities
Annotations
Pathway Ontology: cytochrome P450-independent phase I biotransformation pathway
Participants
Label | Type | Compact Identifier | Comment |
---|---|---|---|
thio esters | Metabolite | chebi:51277 | |
Phosphoric acid esters | Metabolite | chebi:37734 | |
thio esters | Metabolite | chebi:51277 | |
carboxylic acid esters | Metabolite | chebi:33308 | |
amides | Metabolite | chebi:32988 | |
carboxylic acid esters | Metabolite | chebi:33308 | |
Phosphoric acid esters | Metabolite | chebi:37734 | |
amides | Metabolite | chebi:32988 | |
CES7 | GeneProduct | ensembl:ENSG00000159398 | |
ESD | GeneProduct | ensembl:ENSG00000139684 | |
LIPA | GeneProduct | ensembl:ENSG00000107798 | |
PON3 | GeneProduct | ensembl:ENSG00000105852 | |
CES2 | GeneProduct | ensembl:ENSG00000172831 | |
PON2 | GeneProduct | ensembl:ENSG00000105854 | |
CES1 | GeneProduct | ensembl:ENSG00000198848 | |
PON1 | GeneProduct | ensembl:ENSG00000005421 |
References
- Watkins JB, Klaassen CD. Casarett and Doull’s essentials of toxicology [Internet]. New York: McGraw-Hill Medical Pub. Division; 2003. 533 p. Available from: https://openlibrary.org/books/OL17085521M/Casarett_and_Doull’s_essentials_of_toxicology OpenLibrary Worldcat