Apoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and membrane blebbing characterize apoptosis in general. Mitochondria remain morphologically unchanged. In 1972 Kerr et al introduced the concept of apoptosis as a distinct form of "cell-death", and the mechanisms of various apoptotic pathways are still being revealed today.

Authors

Martijn Van Iersel , Kristina Hanspers , Martina Summer-Kutmon , and Levi Wackers

Cited In

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Organism

Danio rerio

Communities

Annotations

Pathway Ontology: regulatory pathway

Participants

References

1. Lakin ND, Jackson SP. Regulation of p53 in response to DNA damage. Oncogene. 1999 Dec 13;18(53):7644–55. PubMed Europe PMC Scholia
2. Mott JL, Kobayashi S, Bronk SF, Gores GJ. mir-29 regulates Mcl-1 protein expression and apoptosis. Oncogene. 2007 Sep 13;26(42):6133–40. PubMed Europe PMC Scholia
3. Bose I, Ghosh B. The p53-MDM2 network: from oscillations to apoptosis. J Biosci. 2007 Aug;32(5):991–7. PubMed Europe PMC Scholia
4. Park S-Y, Lee JH, Ha M, Nam J-W, Kim VN. miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42. Nat Struct Mol Biol. 2009 Jan;16(1):23–9. PubMed Europe PMC Scholia