The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. ''Source: [[wikipedia:Erythropoietin_receptor|Wikipedia]]'' This pathway is based on ScienceSlides.

Authors

Thomas Kelder , Christine Chichester , Martina Summer-Kutmon , and Eric Weitz

Cited In

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Organism

Rattus norvegicus

Communities

Annotations

Pathway Ontology: erythropoietin signaling pathway

Participants

References

1. Zhu Y, D’Andrea AD. The molecular physiology of erythropoietin and the erythropoietin receptor. Curr Opin Hematol. 1994 Mar;1(2):113–8. PubMed Europe PMC Scholia
2. Lacombe C, Mayeux P. The molecular biology of erythropoietin. Nephrol Dial Transplant. 1999;14 Suppl 2:22–8. PubMed Europe PMC Scholia