This pathway is about carotenoid metabolism. It is mainly created by the NuGO focusteam on Carotenoid metabolism. Finally it was subject to a text mining workflow which added some additional entities.

Authors

Alex Pico , Samuel Sklar , Jun Ding , Kristina Hanspers , Strand Life Sciences Pvt. Ltd , Thomas Kelder , Daniela Digles , Egon Willighagen , and Martina Summer-Kutmon

Cited In

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Organism

Mus musculus

Communities

Annotations

Pathway Ontology: retinol metabolic pathway

Participants

References

1. Khachik F, Beecher GR, Goli MB, Lusby WR, Smith JC Jr. Separation and identification of carotenoids and their oxidation products in the extracts of human plasma. Anal Chem. 1992 Sep 15;64(18):2111–22. PubMed Europe PMC Scholia
2. Sies H, Stahl W, Sundquist AR. Antioxidant functions of vitamins. Vitamins E and C, beta-carotene, and other carotenoids. Ann N Y Acad Sci. 1992 Sep 30;669:7–20. PubMed Europe PMC Scholia
3. Micozzi MS, Brown ED, Edwards BK, Bieri JG, Taylor PR, Khachik F, et al. Plasma carotenoid response to chronic intake of selected foods and beta-carotene supplements in men. Am J Clin Nutr. 1992 Jun;55(6):1120–5. PubMed Europe PMC Scholia
4. Sturgeon SR, Ziegler RG, Brinton LA, Nasca PC, Mallin K, Gridley G. Diet and the risk of vulvar cancer. Ann Epidemiol. 1991 Aug;1(5):427–37. PubMed Europe PMC Scholia
5. Botilsrud M, Holmberg I, Wathne KO, Blomhoff HK, Norum KR, Blomhoff R. Effect of retinoids and 1,25(OH)2 vitamin D3 bound to their plasma transport proteins on growth and differentiation of HL-60 cells. Scand J Clin Lab Invest. 1990 May;50(3):309–17. PubMed Europe PMC Scholia
6. Bendich A, Olson JA. Biological actions of carotenoids. FASEB J. 1989 Jun;3(8):1927–32. PubMed Europe PMC Scholia
7. Hidiroglou M, Williams CJ. Interrelationships among liposoluble vitamins in ruminants. Am J Vet Res. 1986 Aug;47(8):1767–71. PubMed Europe PMC Scholia
8. Handelman GJ, Dratz EA, Reay CC, van Kuijk JG. Carotenoids in the human macula and whole retina. Invest Ophthalmol Vis Sci. 1988 Jun;29(6):850–5. PubMed Europe PMC Scholia
9. Olmedilla B, Granado F, Blanco I, Rojas-Hidalgo E. Seasonal and sex-related variations in six serum carotenoids, retinol, and alpha-tocopherol. Am J Clin Nutr. 1994 Jul;60(1):106–10. PubMed Europe PMC Scholia
10. Yong LC, Forman MR, Beecher GR, Graubard BI, Campbell WS, Reichman ME, et al. Relationship between dietary intake and plasma concentrations of carotenoids in premenopausal women: application of the USDA-NCI carotenoid food-composition database. Am J Clin Nutr. 1994 Aug;60(2):223–30. PubMed Europe PMC Scholia
11. Vásárhelyi B, Blázovics A, Fehér J. The role of vitamin A analogues and derivatives in the regulation of cell function. Orv Hetil. 1993 Apr 18;134(16):845–8. PubMed Europe PMC Scholia
12. Satoh T. Fat-soluble vitamins: biotransformation. Nihon Rinsho. 1993 Apr;51(4):865–70. PubMed Europe PMC Scholia
13. Boosalis MG, Snowdon DA, Tully CL, Gross MD. Acute phase response and plasma carotenoid concentrations in older women: findings from the nun study. Nutrition. 1996;12(7–8):475–8. PubMed Europe PMC Scholia
14. VandenLangenberg GM, Brady WE, Nebeling LC, Block G, Forman M, Bowen PE, et al. Influence of using different sources of carotenoid data in epidemiologic studies. J Am Diet Assoc. 1996 Dec;96(12):1271–5. PubMed Europe PMC Scholia
15. Huet F, Semama D, Maingueneau C, Charavel A, Nivelon JL. Vitamin A deficiency and nocturnal vision in teenagers with cystic fibrosis. Eur J Pediatr. 1997 Dec;156(12):949–51. PubMed Europe PMC Scholia
16. Törmä H, Rollman O, Binderup L, Michaelsson G. Vitamin D analogs affect the uptake and metabolism of retinol by human epidermal keratinocytes in culture. J Investig Dermatol Symp Proc. 1996 Apr;1(1):49–53. PubMed Europe PMC Scholia
17. Sommerburg O, Keunen JE, Bird AC, van Kuijk FJ. Fruits and vegetables that are sources for lutein and zeaxanthin: the macular pigment in human eyes. Br J Ophthalmol. 1998 Aug;82(8):907–10. PubMed Europe PMC Scholia
18. Amir H, Karas M, Giat J, Danilenko M, Levy R, Yermiahu T, et al. Lycopene and 1,25-dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells. Nutr Cancer. 1999;33(1):105–12. PubMed Europe PMC Scholia
19. Johansson S, Melhus H. Vitamin A antagonizes calcium response to vitamin D in man. J Bone Miner Res. 2001 Oct;16(10):1899–905. PubMed Europe PMC Scholia
20. Balmer JE, Blomhoff R. Gene expression regulation by retinoic acid. J Lipid Res. 2002 Nov;43(11):1773–808. PubMed Europe PMC Scholia
21. Heber D, Lu Q-Y. Overview of mechanisms of action of lycopene. Exp Biol Med (Maywood). 2002 Nov;227(10):920–3. PubMed Europe PMC Scholia
22. Ruhl CE, Everhart JE. Relation of elevated serum alanine aminotransferase activity with iron and antioxidant levels in the United States. Gastroenterology. 2003 Jun;124(7):1821–9. PubMed Europe PMC Scholia
23. Czeczuga-Semeniuk E, Wołczyński S, Markiewicz W. Preliminary identification of carotenoids in malignant and benign neoplasms of the breast and surrounding fatty tissue. Neoplasma. 2003;50(4):280–6. PubMed Europe PMC Scholia