Notch signaling pathway (WP1232)

Anopheles gambiae

The Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch proteins (Notch1-Notch4 in vertebrates) are single-pass receptors that are activated by the Delta (or Delta-like) and Jagged/Serrate families of membrane-bound ligands. They are transported to the plasma membrane as cleaved, but otherwise intact polypeptides. Interaction with ligand leads to two additional proteolytic cleavages that liberate the Notch intracellular domain (NICD) from the plasma membrane. The NICD translocates to the nucleus, where it forms a complex with the DNA binding protein CSL, displacing a histone deacetylase (HDAc)-co-repressor (CoR) complex from CSL. Components of an activation complex, such as MAML1 and histone acetyltransferases (HATs), are recruited to the NICD-CSL complex, leading to the transcriptional activation of Notch target genes. Source: [ KEGG] Adapted from KEGG:
last edited


Thomas Kelder , Daniela Digles , Eric Weitz , and Alex Pico

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Anopheles gambiae



Pathway Ontology: Notch signaling pathway


Label Type Compact Identifier Comment
HDAC2 GeneProduct ensembl:AGAP006511
CTBP1 GeneProduct ensembl:AGAP003893
CTBP2 GeneProduct ensembl:AGAP003893
CREBBP GeneProduct ensembl:AGAP000029
GCN5L2 GeneProduct ensembl:AGAP004434
PCAF GeneProduct ensembl:AGAP004434
DLL1 GeneProduct ensembl:AGAP010265
DLL4 GeneProduct ensembl:AGAP010265
JAG1 GeneProduct ensembl:AGAP004154
JAG2 GeneProduct ensembl:AGAP004154
LFNG GeneProduct ensembl:AGAP006439
MFNG GeneProduct ensembl:AGAP006439
RFNG GeneProduct ensembl:AGAP006439
NOTCH2 GeneProduct ensembl:AGAP001015
NOTCH3 GeneProduct ensembl:AGAP001015
NOTCH4 GeneProduct ensembl:AGAP003873
ADAM17 GeneProduct ensembl:AGAP002381
APH1A GeneProduct ensembl:AGAP009816
APH1B GeneProduct ensembl:AGAP009816
PSEN1 GeneProduct ensembl:AGAP002957
PSEN2 GeneProduct ensembl:AGAP002957
NCSTN GeneProduct ensembl:AGAP001734
DVL1 GeneProduct ensembl:AGAP004448
DVL2 GeneProduct ensembl:AGAP004448
DVL3 GeneProduct ensembl:AGAP004448
NUMB GeneProduct ensembl:AGAP010167
NUMBL GeneProduct ensembl:AGAP010167
DTX1 GeneProduct ensembl:AGAP000903
DTX2 GeneProduct ensembl:AGAP000903
DTX3 GeneProduct ensembl:AGAP000903
DTX4 GeneProduct ensembl:AGAP000903
DTX3L GeneProduct ensembl:AGAP000903
AgaP_AGAP008935 GeneProduct ncbigene:1279906
NOTCH1 GeneProduct ensembl:AGAP001015
HDAC1 GeneProduct ensembl:AGAP006511
AgaP_AGAP001283 GeneProduct ncbigene:1281896
SKIP GeneProduct ensembl:AGAP011644


  1. The ins and outs of notch signaling. Weinmaster G. Mol Cell Neurosci. 1997;9(2):91–102. PubMed Europe PMC Scholia