Integrin-mediated cell adhesion (WP1185)

Canis familiaris

Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and thereby define cellular shape, mobility, and regulate the cell cycle. Source: [[wikipedia:Integrins|Wikipedia]]
How to Cite
Download PNG Download SVG Download JSON Download GPML
last edited

Authors

Thomas Kelder and Daniela Digles

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organism

Canis familiaris

Communities

Annotations

Pathway Ontology: integrin mediated signaling pathway

Participants

Label Type Compact Identifier Comment
CDC42 GeneProduct ncbigene:607535 CDC42; cell division cycle 42 (GTP binding protein 25kD)
SHC1 GeneProduct ncbigene:490439 SHC1; SHC (Src homology 2 domain containing) transforming protein 1
LOC476352 GeneProduct ncbigene:476352 SHC3; neuronal Sh
ARAF GeneProduct ncbigene:491857 ARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-]
BRAF GeneProduct ncbigene:475526 BRAF; v-raf murine sarcoma viral oncogene homolog B1 [EC:2.7.1.-]
RAF1 GeneProduct ncbigene:484648 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
MAPK4 GeneProduct ncbigene:491690 MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]
MAPK7 GeneProduct ncbigene:489532 MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-
CAPNS1 GeneProduct ncbigene:611746 CAPNS1; calpain small subunit 1 [EC:3.4.22.17]
MYLK2 GeneProduct ncbigene:477187 MYLK2; myosin light chain kinase 2 skeletal muscle [EC:2.7.1.117
ARHGEF7 GeneProduct ncbigene:485552 ARHGEF7; Rho guanine nucleotide exchange factor (GEF) 7
RAC1 GeneProduct ncbigene:403955 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1)
RAC2 GeneProduct ncbigene:481271 RAC2; ras-related C3 botulinum toxin substrate 2 (rho family small GTP binding protein Rac2)
PDPK1 GeneProduct ncbigene:479875 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.1.37]
VAV2 GeneProduct ncbigene:608060 VAV2; vav 2 oncogene
VAV3 GeneProduct ncbigene:479921 VAV3; vav 3 oncogene
ROCK2 GeneProduct ncbigene:482970 ROCK2; Rho-associated coiled-coil containing protein kinase
ROCK1 GeneProduct ncbigene:480181 ROCK1; Rho-associated coiled-coil containing protein kinase
SOS1 GeneProduct ncbigene:483042 SOS1; son of sevenless homolog 1 (Drosophila)
GIT2 GeneProduct ncbigene:477520 GIT2; G protein-coupled receptor kinase-interactor 2
PIK3R2 GeneProduct ncbigene:609956 PIK3R2; phosphoinositide-3-kinase regulatory subunit polypeptide 2 (p85 beta)
ZYX GeneProduct ncbigene:482736 ZYX; zyxin
CAV1 GeneProduct ncbigene:403980 CAV1; caveolin 1 caveolae protein 22kD
CAV2 GeneProduct ncbigene:475294 CAV2; caveolin 2
CAV3 GeneProduct ncbigene:484671 CAV3; caveolin 3
FYN GeneProduct ncbigene:475032 FYN; FYN oncogene related to SRC FGR YES [EC:2.7.1.112]
GRB2 GeneProduct ncbigene:483312 GRB2; growth factor receptor-bound protein 2
SEPP1 GeneProduct ncbigene:479346 SEPP1; selenoprotein P plasma
PTK2 GeneProduct ncbigene:475108 PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112
PTK2 GeneProduct ncbigene:475108 PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112
RHO GeneProduct ncbigene:493763 RHO; rhodopsin (opsin 2 rod pigment) (retinitis pigmentosa 4 autosomal dominant)
CSK GeneProduct ncbigene:487649 CSK; c-src tyrosine kinase [EC:2.7.1.112]
BCAR1 GeneProduct ncbigene:479648 BCAR1; breast cancer anti-estrogen resistance 1
SRC GeneProduct ncbigene:485864 SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]
AKT1 GeneProduct ncbigene:490878 AKT1; v-akt murine thymoma viral oncogene homolog 1 [EC:2.7.1.-]
AKT2 GeneProduct ncbigene:449021 AKT2; v-akt murine thymoma viral oncogene homolog 2 [EC:2.7.1.-]
CAPN2 GeneProduct ncbigene:480118 CAPN2; calpain 2 (m/II) large subunit [EC:3.4.22.17]
CAPN3 GeneProduct ncbigene:487518 CAPN3; calpain 3 (p94) [EC:3.4.22.17]
CAPN5 GeneProduct ncbigene:485175 CAPN5; calpain
CAPN7 GeneProduct ncbigene:477062 CAPN7; calpain 7 [EC:3.4.22.17
CAPN9 GeneProduct ncbigene:608044 CAPN9; calpain 9 (nCL-4) [EC:3.4.22.17
CAPN10 GeneProduct ncbigene:607311 CAPN10; calpain 10 [EC:3.4.22.17
CAPN11 GeneProduct ncbigene:609624 CAPN11; calpain 11 [EC:3.4.22.17]
CAPN6 GeneProduct ncbigene:492068 CAPN6; calpain 6 [EC:3.4.22.17]
PAK2 GeneProduct ncbigene:612814 PAK2; p21 (CDKN1A)-activated kinase 2 [EC:2.7.1.-]
PAK3 GeneProduct ncbigene:492067 PAK3; p21 (CDKN1A)-activated kinase 3 [EC:2.7.1.-]
PAK4 GeneProduct ncbigene:484513 PAK4; p21(CDKN1A)-activated kinase 4 [EC:2.7.1.-]
PAK6 GeneProduct ncbigene:487490 PAK6; p21(CDKN1A)-activated kinase
TLN1 GeneProduct ncbigene:474759 TLN1; talin 1
MAP2K3 GeneProduct ncbigene:489547 MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]
MAP2K6 GeneProduct ncbigene:480454 MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-
MAPK12 GeneProduct ncbigene:607023 MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-]
AKT3 GeneProduct ncbigene:442964 AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) [EC:2.7.1.-]
DOCK1 GeneProduct ncbigene:486934 DOCK1; dedicator of cyto-kinesis
RAPGEF1 GeneProduct ncbigene:491286 GRF2; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene
RAP1A GeneProduct ncbigene:483225 RAP1A; RAP1A member of RAS oncogene family
RAP1B GeneProduct ncbigene:608981 RAP1B; RAP1B member of RAS oncogene family
MAPK1 GeneProduct ncbigene:477575 MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
MAPK6 GeneProduct ncbigene:478311 MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]
MAP2K1 GeneProduct ncbigene:478347 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
MAP2K2 GeneProduct ncbigene:611939 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]
CAPN1 GeneProduct ncbigene:483745 CAPN1; calpain 1 (mu/I) large subunit [EC:3.4.22.17]
ITGA2 GeneProduct ncbigene:489208
ITGA4 GeneProduct ncbigene:488429
ITGA5 GeneProduct ncbigene:486493
ITGA6 GeneProduct ncbigene:478800
ITGA8 GeneProduct ncbigene:487119
ITGA9 GeneProduct ncbigene:477021
ITGA10 GeneProduct ncbigene:608287
ITGA11 GeneProduct ncbigene:478353
ITGA2B GeneProduct ncbigene:403789
ITGAE GeneProduct ncbigene:480659
ITGAD GeneProduct ncbigene:607096
ITGAL GeneProduct ncbigene:489905
ITGAM GeneProduct ncbigene:489928
ITGAV GeneProduct ncbigene:488437
ITGAX GeneProduct ncbigene:489929
ITGB1 GeneProduct ncbigene:477956
ITGB2 GeneProduct ncbigene:403770
ITGB3 GeneProduct ncbigene:403788
ITGB4 GeneProduct ncbigene:483318
ITGB5 GeneProduct ncbigene:608977
ITGB6 GeneProduct ncbigene:488368
ITGB7 GeneProduct ncbigene:477598
ITGB8 GeneProduct ncbigene:475253
SRC GeneProduct ncbigene:485864 SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]
TNS1 GeneProduct ncbigene:488519 TNS; tensi
MAPK10 GeneProduct ncbigene:478464
PXN GeneProduct ncbigene:486299 PXN; paxillin
ILK GeneProduct ncbigene:476836 ILK; integrin-linked kinase [EC:2.7.1.-]
PAK1 GeneProduct ncbigene:607885 PAK1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog yeast) [EC:2.7.1.-]
VASP GeneProduct ncbigene:403936 VASP; vasodilator-stimulated phosphoprotein
ITGA7 GeneProduct ncbigene:481097
ITGA1 GeneProduct ncbigene:489210
Download TSV Query Drugst.One

References

  1. Assembly and signaling of adhesion complexes. Sepulveda JL, Gkretsi V, Wu C. Curr Top Dev Biol. 2005;68:183–225. PubMed Europe PMC Scholia