G13 signaling pathway (WP1179)
Canis familiaris
The G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cells and is essential for receptor tyrosine kinase-induced migration of fibroblast and endothelial cells. Source: [[wikipedia:G12/G13_alpha_subunits|Wikipedia]]
Authors
Thomas Kelder , Christine Chichester , Martina Summer-Kutmon , and Eric WeitzCited In
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Organism
Canis familiarisCommunities
Annotations
Pathway Ontology: G protein mediated signaling pathway G protein mediated signaling pathway via Galpha12/Galpha13 family
Participants
| Label | Type | Compact Identifier | Comment |
|---|---|---|---|
| RTKN | GeneProduct | ensembl:ENSCAFG00000008519 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6242 |
| PKN1 | GeneProduct | ensembl:ENSCAFG00000016316 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5585 |
| CFL2 | GeneProduct | ensembl:ENSCAFG00000032562 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1073 |
| RHPN2 | GeneProduct | ensembl:ENSCAFG00000007465 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:85415 |
| RHOA | GeneProduct | ensembl:ENSCAFG00000018512 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:387 |
| PFN1 | GeneProduct | ensembl:ENSCAFG00000015827 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5216 |
| ARHGEF1 | GeneProduct | ensembl:ENSCAFG00000030005 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:9138 |
| CYFIP1 | GeneProduct | ensembl:ENSCAFG00000009720 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:23191 |
| GNA13 | GeneProduct | ensembl:ENSCAFG00000011108 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10672 |
| IQGAP2 | GeneProduct | ensembl:ENSCAFG00000009293 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10788 |
| IQGAP1 | GeneProduct | ensembl:ENSCAFG00000012639 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8826 |
| PIK3CD | GeneProduct | ensembl:ENSCAFG00000019735 | P42338Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5293 |
| ARHGDIB | GeneProduct | ensembl:ENSCAFG00000012883 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:397 |
| PIK3CB | GeneProduct | ensembl:ENSCAFG00000007579 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5291 |
| SH3RF1 | GeneProduct | ensembl:ENSCAFG00000007608 | PoshHomology Mapping from Homo sapiens to Canis familiaris: Original ID = L:57630 |
| LIMK1 | GeneProduct | ensembl:ENSCAFG00000012073 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3984 |
| MYBPH | GeneProduct | ensembl:ENSCAFG00000010288 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4608 |
| RAC1 | GeneProduct | ensembl:ENSCAFG00000015716 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5879 |
| TNK2 | GeneProduct | ensembl:ENSCAFG00000012918 | S33596Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10188 |
| PAK3 | GeneProduct | ensembl:ENSCAFG00000018154 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5063 |
| PIP5K2A | GeneProduct | ensembl:ENSCAFG00000013718 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5305 |
| MAPK10 | GeneProduct | ensembl:ENSCAFG00000009396 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5602 |
| CALM1 | GeneProduct | ensembl:ENSCAFG00000017563 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:801 |
| WASL | GeneProduct | ensembl:ENSCAFG00000001771 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8976 |
| PIK3R2 | GeneProduct | ensembl:ENSCAFG00000014978 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5296 |
| PPP1CB | GeneProduct | ensembl:ENSCAFG00000005238 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5500 |
| WAS | GeneProduct | ensembl:ENSCAFG00000015519 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7454 |
| MAP3K4 | GeneProduct | ensembl:ENSCAFG00000000760 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4216 |
| MYL1 | GeneProduct | ensembl:ENSCAFG00000013875 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4632 |
| CIT | GeneProduct | ensembl:ENSCAFG00000010114 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:11113 |
| ARHGDIG | GeneProduct | ensembl:ENSCAFG00000015363 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:398 |
| ROCK1 | GeneProduct | ensembl:ENSCAFG00000018282 | S69211Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6093 |
| DIAPH1 | GeneProduct | ensembl:ENSCAFG00000006149 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1729 |
| PIK3CA | GeneProduct | ensembl:ENSCAFG00000011212 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5290 |
| CDC42 | GeneProduct | ensembl:ENSCAFG00000014707 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:998 |
| RPS6KB1 | GeneProduct | ensembl:ENSCAFG00000017679 | A41687Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6198 |
| ROCK2 | GeneProduct | ensembl:ENSCAFG00000003549 | BAA31594Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:9475 |
| CFL1 | GeneProduct | ensembl:ENSCAFG00000020009 | Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1072 |
References
- G protein pathways. Neves SR, Ram PT, Iyengar R. Science. 2002 May 31;296(5573):1636–9. PubMed Europe PMC Scholia