G protein signaling pathways (WP1165)
Canis familiaris
G proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades. G proteins are so called because they function as "molecular switches". They alternate from 'inactive' guanosine diphosphate (GDP) to 'active' guanosine triphosphate (GTP), which is a binding state, and which proceeds to regulate downstream cell processes. Source: [[wikipedia:G_protein|Wikipedia]]
Authors
Thomas Kelder , Christine Chichester , and Eric WeitzCited In
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Organism
Canis familiarisCommunities
Annotations
Pathway Ontology: G protein mediated signaling pathway
Participants
Label | Type | Compact Identifier | Comment |
---|---|---|---|
IP3 | Metabolite | hmdb:HMDB0001143 | |
Ca2+ | Metabolite | hmdb:HMDB0000464 | |
DAG | Metabolite | kegg.compound:C00165 | |
cAMP | Metabolite | hmdb:HMDB0000058 | |
PRKAR2B | GeneProduct | ncbigene:475887 | |
PDE7B | GeneProduct | ncbigene:483996 | |
ADCY3 | GeneProduct | ncbigene:482994 | |
ADCY5 | GeneProduct | ncbigene:403859 | |
GNG11 | GeneProduct | ncbigene:610002 | |
AKAP8 | GeneProduct | ncbigene:474362 | |
PPP3CC | GeneProduct | ncbigene:609027 | |
AKAP1 | GeneProduct | ncbigene:480567 | |
PRKAR1B | GeneProduct | ncbigene:480805 | |
GNAS | GeneProduct | ncbigene:403943 | |
PRKCD | GeneProduct | ncbigene:494005 | |
GNB3 | GeneProduct | ncbigene:403511 | |
GNAQ | GeneProduct | ncbigene:403928 | |
GNAO1 | GeneProduct | ncbigene:609157 | |
PDE4D | GeneProduct | ncbigene:487221 | |
PRKCB | GeneProduct | ncbigene:489968 | |
RRAS | GeneProduct | ncbigene:476413 | |
GNA14 | GeneProduct | ncbigene:484156 | |
AKAP5 | GeneProduct | ncbigene:480354 | |
GNAZ | GeneProduct | ncbigene:607445 | |
ADCY4 | GeneProduct | ncbigene:480271 | |
PDE8B | GeneProduct | ncbigene:488939 | |
NRAS | GeneProduct | ncbigene:403872 | |
LOC611349 | GeneProduct | ncbigene:611349 | |
GNGT1 | GeneProduct | ncbigene:403895 | |
GNB2 | GeneProduct | ncbigene:479733 | |
PRKAR1A | GeneProduct | ncbigene:480459 | |
GNA11 | GeneProduct | ncbigene:403914 | |
PRKCH | GeneProduct | ncbigene:490722 | |
PPP3CA | GeneProduct | ncbigene:403486 | |
GNAI1 | GeneProduct | ncbigene:478227 | |
CALM1 | GeneProduct | ncbigene:480416 | |
PRKACB | GeneProduct | ncbigene:479975 | |
PRKAR2A | GeneProduct | ncbigene:484774 | |
GNB5 | GeneProduct | ncbigene:608623 | |
KCNJ3 | GeneProduct | ncbigene:488355 | |
PLCB3 | GeneProduct | ncbigene:476034 | |
AKAP7 | GeneProduct | ncbigene:484128 | |
GNA13 | GeneProduct | ncbigene:490901 | |
Adcy6 | GeneProduct | ncbigene:477625 | |
AKAP3 | GeneProduct | ncbigene:477719 | |
PDE1A | GeneProduct | ncbigene:403652 | |
PDE1C | GeneProduct | ncbigene:475272 | |
ADCY2 | GeneProduct | ncbigene:478624 | |
GNAO1 | GeneProduct | ncbigene:609157 | |
GNAL | GeneProduct | ncbigene:607658 | |
PRKD1 | GeneProduct | ncbigene:609091 | |
PRKD3 | GeneProduct | ncbigene:483036 | |
ADCY9 | GeneProduct | ncbigene:490031 | |
AKAP6 | GeneProduct | ncbigene:490644 | |
PPP3CC | GeneProduct | ncbigene:609027 | |
AKAP13 | GeneProduct | ncbigene:479032 | |
GNA15 | GeneProduct | ncbigene:485063 | |
PDE8A | GeneProduct | ncbigene:488752 | |
AKAP12 | GeneProduct | ncbigene:476246 | |
RHOA | GeneProduct | ncbigene:403954 | |
AKAP4 | GeneProduct | ncbigene:480917 | |
GNAI3 | GeneProduct | ncbigene:611810 | |
AKAP11 | GeneProduct | ncbigene:609431 | |
GNGT2 | GeneProduct | ncbigene:403617 | |
PRKCQ | GeneProduct | ncbigene:478013 | |
PDE4C | GeneProduct | ncbigene:609938 | |
GNG8 | GeneProduct | ncbigene:484428 | |
PRKCE | GeneProduct | ncbigene:609934 | |
GNG7 | GeneProduct | ncbigene:612139 | |
PRKCG | GeneProduct | ncbigene:484316 | |
GNB1 | GeneProduct | ncbigene:403912 | |
PRKCA | GeneProduct | ncbigene:490904 | |
PRKCI | GeneProduct | ncbigene:478686 | |
GNG3 | GeneProduct | ncbigene:483783 | |
PRKCZ | GeneProduct | ncbigene:479577 | |
AKAP10 | GeneProduct | ncbigene:609073 | |
GNAI1 | GeneProduct | ncbigene:478227 | |
ADCY8 | GeneProduct | ncbigene:482045 | |
ADCY7 | GeneProduct | ncbigene:487289 | |
PRKACA | GeneProduct | ncbigene:403556 | |
PDE4B | GeneProduct | ncbigene:479540 | |
HRAS | GeneProduct | ncbigene:403735 | |
PDE7A | GeneProduct | ncbigene:486975 | |
AKAP9 | GeneProduct | ncbigene:475224 | |
GNG4 | GeneProduct | ncbigene:607513 | |
GNA12 | GeneProduct | ncbigene:609567 | |
ITPR1 | GeneProduct | ncbigene:476548 | |
SLC9A1 | GeneProduct | ncbigene:478171 | |
GNAI2 | GeneProduct | ncbigene:442957 |
References
- G proteins: a family of signal transducers. Stryer L, Bourne HR. Annu Rev Cell Biol. 1986;2:391–419. PubMed Europe PMC Scholia
- G protein pathways. Neves SR, Ram PT, Iyengar R. Science. 2002 May 31;296(5573):1636–9. PubMed Europe PMC Scholia