Integrin-mediated cell adhesion (WP1069)
Bos taurus
Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and thereby define cellular shape, mobility, and regulate the cell cycle. Source: [[wikipedia:Integrins|Wikipedia]]
Authors
Thomas Kelder , Daniela Digles , Martina Summer-Kutmon , and Eric WeitzCited In
Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.
Organism
Bos taurusCommunities
Annotations
Pathway Ontology: integrin mediated signaling pathway
Participants
| Label | Type | Compact Identifier | Comment |
|---|---|---|---|
| CDC42 | GeneProduct | ensembl:ENSBTAG00000001700 | CDC42; cell division cycle 42 (GTP binding protein 25kD)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:998 |
| SHC1 | GeneProduct | ensembl:ENSBTAG00000019838 | SHC1; SHC (Src homology 2 domain containing) transforming protein 1HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6464 |
| SHC3 | GeneProduct | ensembl:ENSBTAG00000011375 | SHC3; neuronal ShHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:53358 |
| ARAF | GeneProduct | ensembl:ENSBTAG00000005039 | ARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:369 |
| BRAF | GeneProduct | ensembl:ENSBTAG00000021761 | BRAF; v-raf murine sarcoma viral oncogene homolog B1 [EC:2.7.1.-]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:673 |
| RAF1 | GeneProduct | ensembl:ENSBTAG00000045748 | RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894 |
| MAPK4 | GeneProduct | ensembl:ENSBTAG00000009907 | MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5596 |
| MAPK7 | GeneProduct | ensembl:ENSBTAG00000001014 | MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5598 |
| CAPNS1 | GeneProduct | ensembl:ENSBTAG00000014872 | CAPNS1; calpain small subunit 1 [EC:3.4.22.17]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:826 |
| MYLK2 | GeneProduct | ensembl:ENSBTAG00000014930 | MYLK2; myosin light chain kinase 2 skeletal muscle [EC:2.7.1.117HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:85366 |
| ARHGEF7 | GeneProduct | ensembl:ENSBTAG00000020726 | ARHGEF7; Rho guanine nucleotide exchange factor (GEF) 7HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8874 |
| RAC1 | GeneProduct | ensembl:ENSBTAG00000009233 | RAC1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5879 |
| RAC2 | GeneProduct | ensembl:ENSBTAG00000011043 | RAC2; ras-related C3 botulinum toxin substrate 2 (rho family small GTP binding protein Rac2)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5880 |
| RAC3 | GeneProduct | ensembl:ENSBTAG00000022927 | RAC3; ras-related C3 botulinum toxin substrate 3 (rho family small GTP binding protein Rac3)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5881 |
| PDPK1 | GeneProduct | ensembl:ENSBTAG00000034436 | PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.1.37]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5170 |
| VAV2 | GeneProduct | ensembl:ENSBTAG00000004511 | VAV2; vav 2 oncogeneHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7410 |
| VAV3 | GeneProduct | ensembl:ENSBTAG00000031575 | VAV3; vav 3 oncogeneHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10451 |
| ROCK2 | GeneProduct | ensembl:ENSBTAG00000005847 | ROCK2; Rho-associated coiled-coil containing protein kinaseHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9475 |
| ROCK1 | GeneProduct | ensembl:ENSBTAG00000008403 | ROCK1; Rho-associated coiled-coil containing protein kinaseHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6093 |
| SORBS1 | GeneProduct | ensembl:ENSBTAG00000002880 | SH3D5; SH3-domain protein 5 (ponsinHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10580 |
| SOS1 | GeneProduct | ensembl:ENSBTAG00000011643 | SOS1; son of sevenless homolog 1 (Drosophila)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6654 |
| GIT2 | GeneProduct | ensembl:ENSBTAG00000006506 | GIT2; G protein-coupled receptor kinase-interactor 2HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9815 |
| ZYX | GeneProduct | ensembl:ENSBTAG00000017970 | ZYX; zyxinHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7791 |
| CAV1 | GeneProduct | ensembl:ENSBTAG00000017869 | CAV1; caveolin 1 caveolae protein 22kDHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:857 |
| CAV2 | GeneProduct | ensembl:ENSBTAG00000045584 | CAV2; caveolin 2HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:858 |
| CAV3 | GeneProduct | ensembl:ENSBTAG00000022699 | CAV3; caveolin 3HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:859 |
| FYN | GeneProduct | ensembl:ENSBTAG00000011851 | FYN; FYN oncogene related to SRC FGR YES [EC:2.7.1.112]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2534 |
| GRB2 | GeneProduct | ensembl:ENSBTAG00000004736 | GRB2; growth factor receptor-bound protein 2HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2885 |
| HRAS | GeneProduct | ensembl:ENSBTAG00000046644 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265 |
| PTK2 | GeneProduct | ensembl:ENSBTAG00000009578 | PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5747 |
| PTK2 | GeneProduct | ensembl:ENSBTAG00000009578 | PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5747 |
| RHO | GeneProduct | ensembl:ENSBTAG00000001310 | RHO; rhodopsin (opsin 2 rod pigment) (retinitis pigmentosa 4 autosomal dominant)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6010 |
| CSK | GeneProduct | ensembl:ENSBTAG00000021424 | CSK; c-src tyrosine kinase [EC:2.7.1.112]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1445 |
| BCAR1 | GeneProduct | ensembl:ENSBTAG00000012002 | BCAR1; breast cancer anti-estrogen resistance 1HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9564 |
| SRC | GeneProduct | ensembl:ENSBTAG00000008938 | SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714 |
| AKT1 | GeneProduct | ensembl:ENSBTAG00000017636 | AKT1; v-akt murine thymoma viral oncogene homolog 1 [EC:2.7.1.-]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207 |
| AKT2 | GeneProduct | ensembl:ENSBTAG00000001400 | AKT2; v-akt murine thymoma viral oncogene homolog 2 [EC:2.7.1.-]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:208 |
| MYPN | GeneProduct | ensembl:ENSBTAG00000017509 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138347 |
| CAPN2 | GeneProduct | ensembl:ENSBTAG00000012778 | CAPN2; calpain 2 (m/II) large subunit [EC:3.4.22.17]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:824 |
| CAPN3 | GeneProduct | ensembl:ENSBTAG00000008868 | CAPN3; calpain 3 (p94) [EC:3.4.22.17]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:825 |
| CAPN5 | GeneProduct | ensembl:ENSBTAG00000005034 | CAPN5; calpainHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:726 |
| CAPN7 | GeneProduct | ensembl:ENSBTAG00000006479 | CAPN7; calpain 7 [EC:3.4.22.17HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23473 |
| CAPN10 | GeneProduct | ensembl:ENSBTAG00000002809 | CAPN10; calpain 10 [EC:3.4.22.17HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11132 |
| CAPN11 | GeneProduct | ensembl:ENSBTAG00000021066 | CAPN11; calpain 11 [EC:3.4.22.17]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11131 |
| CAPN6 | GeneProduct | ensembl:ENSBTAG00000000828 | CAPN6; calpain 6 [EC:3.4.22.17]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:827 |
| PAK2 | GeneProduct | ensembl:ENSBTAG00000047856 | PAK2; p21 (CDKN1A)-activated kinase 2 [EC:2.7.1.-]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5062 |
| PAK3 | GeneProduct | ensembl:ENSBTAG00000015670 | PAK3; p21 (CDKN1A)-activated kinase 3 [EC:2.7.1.-]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5063 |
| PAK4 | GeneProduct | ensembl:ENSBTAG00000013958 | PAK4; p21(CDKN1A)-activated kinase 4 [EC:2.7.1.-]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10298 |
| PAK6 | GeneProduct | ensembl:ENSBTAG00000019076 | PAK6; p21(CDKN1A)-activated kinaseHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:56924 |
| TLN1 | GeneProduct | ensembl:ENSBTAG00000025868 | TLN1; talin 1HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7094 |
| MAP2K3 | GeneProduct | ensembl:ENSBTAG00000010576 | MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5606 |
| MAP2K5 | GeneProduct | ensembl:ENSBTAG00000000218 | MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5607 |
| MAP2K6 | GeneProduct | ensembl:ENSBTAG00000001609 | MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5608 |
| MAPK12 | GeneProduct | ensembl:ENSBTAG00000019574 | MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6300 |
| AKT3 | GeneProduct | ensembl:ENSBTAG00000017788 | AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) [EC:2.7.1.-]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10000 |
| DOCK1 | GeneProduct | ensembl:ENSBTAG00000031890 | DOCK1; dedicator of cyto-kinesisHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1793 |
| CRK | GeneProduct | ensembl:ENSBTAG00000005665 | CRK; v-crk sarcoma virus CT10 oncogene homolog (avianHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1398 |
| RAPGEF1 | GeneProduct | ensembl:ENSBTAG00000020791 | GRF2; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogeneHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2889 |
| RAP1A | GeneProduct | ensembl:ENSBTAG00000014710 | RAP1A; RAP1A member of RAS oncogene familyHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5906 |
| RAP1B | GeneProduct | ensembl:ENSBTAG00000008967 | RAP1B; RAP1B member of RAS oncogene familyHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5908 |
| MAPK1 | GeneProduct | ensembl:ENSBTAG00000010312 | MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594 |
| MAPK6 | GeneProduct | ensembl:ENSBTAG00000005865 | MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5597 |
| MAP2K1 | GeneProduct | ensembl:ENSBTAG00000033983 | MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604 |
| MAP2K2 | GeneProduct | ensembl:ENSBTAG00000024450 | MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605 |
| CAPN1 | GeneProduct | ensembl:ENSBTAG00000010230 | CAPN1; calpain 1 (mu/I) large subunit [EC:3.4.22.17]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:823 |
| ITGA2 | GeneProduct | ensembl:ENSBTAG00000019289 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3673 |
| ITGA3 | GeneProduct | ensembl:ENSBTAG00000019498 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3675 |
| ITGA4 | GeneProduct | ensembl:ENSBTAG00000009256 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3676 |
| ITGA5 | GeneProduct | ensembl:ENSBTAG00000013745 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3678 |
| ITGA6 | GeneProduct | ensembl:ENSBTAG00000017266 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3655 |
| ITGA8 | GeneProduct | ensembl:ENSBTAG00000007602 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8516 |
| ITGA9 | GeneProduct | ensembl:ENSBTAG00000016566 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3680 |
| ITGA10 | GeneProduct | ensembl:ENSBTAG00000008373 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8515 |
| ITGA11 | GeneProduct | ensembl:ENSBTAG00000008380 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:22801 |
| ITGA2B | GeneProduct | ensembl:ENSBTAG00000008165 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3674 |
| ITGAE | GeneProduct | ensembl:ENSBTAG00000015264 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3682 |
| ITGAD | GeneProduct | ensembl:ENSBTAG00000019524 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3681 |
| ITGAL | GeneProduct | ensembl:ENSBTAG00000007103 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3683 |
| ITGAM | GeneProduct | ensembl:ENSBTAG00000047238 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3684 |
| ITGAV | GeneProduct | ensembl:ENSBTAG00000019929 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3685 |
| ITGB1 | GeneProduct | ensembl:ENSBTAG00000015910 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3688 |
| ITGB2 | GeneProduct | ensembl:ENSBTAG00000017060 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3689 |
| INTB3 | GeneProduct | ensembl:ENSBTAG00000009987 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3690 |
| ITGB4 | GeneProduct | ensembl:ENSBTAG00000018169 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3691 |
| ITGB5 | GeneProduct | ensembl:ENSBTAG00000013755 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3693 |
| ITGB6 | GeneProduct | ensembl:ENSBTAG00000009080 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3694 |
| ITGB7 | GeneProduct | ensembl:ENSBTAG00000018993 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3695 |
| ITGB8 | GeneProduct | ensembl:ENSBTAG00000003709 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3696 |
| SRC | GeneProduct | ensembl:ENSBTAG00000008938 | SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714 |
| VCL | GeneProduct | ensembl:ENSBTAG00000021879 | VCL; vinculinHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7414 |
| TNS1 | GeneProduct | ensembl:ENSBTAG00000002485 | TNS; tensiHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7145 |
| MAPK10 | GeneProduct | ensembl:ENSBTAG00000020048 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5602 |
| PXN | GeneProduct | ensembl:ENSBTAG00000018108 | PXN; paxillinHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5829 |
| ILK | GeneProduct | ensembl:ENSBTAG00000000696 | ILK; integrin-linked kinase [EC:2.7.1.-]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3611 |
| PAK1 | GeneProduct | ensembl:ENSBTAG00000010191 | PAK1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog yeast) [EC:2.7.1.-]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5058 |
| VASP | GeneProduct | ensembl:ENSBTAG00000019604 | VASP; vasodilator-stimulated phosphoproteinHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7408 |
| ITGA7 | GeneProduct | ensembl:ENSBTAG00000012897 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3679 |
| ITGA1 | GeneProduct | ensembl:ENSBTAG00000016525 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3672 |
| bta-mir-34c | GeneProduct | ensembl:ENSBTAG00000029991 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207562 |
References
- Assembly and signaling of adhesion complexes. Sepulveda JL, Gkretsi V, Wu C. Curr Top Dev Biol. 2005;68:183–225. PubMed Europe PMC Scholia
- The miR-34 family in cancer and apoptosis. Hermeking H. Cell Death Differ. 2010 Feb;17(2):193–9. PubMed Europe PMC Scholia