FAS pathway and stress induction of HSP regulation (WP1019)
Bos taurus
This pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].
Authors
Thomas Kelder , Kristina Hanspers , Christine Chichester , Martina Summer-Kutmon , Eric Weitz , and Egon WillighagenCited In
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Organism
Bos taurusCommunities
Annotations
Pathway Ontology: stress response pathway FasL mediated signaling pathway
Participants
| Label | Type | Compact Identifier | Comment |
|---|---|---|---|
| Phosphate | Metabolite | hmdb:HMDB0001429 | |
| Glutathione | Metabolite | hmdb:HMDB0000125 | |
| Phosphate | Metabolite | hmdb:HMDB0001429 | |
| Phosphate | Metabolite | hmdb:HMDB0001429 | |
| Phosphate | Metabolite | hmdb:HMDB0001429 | |
| Phosphate | Metabolite | hmdb:HMDB0001429 | |
| Phosphate | Metabolite | hmdb:HMDB0001429 | |
| Phosphate | Metabolite | hmdb:HMDB0001429 | |
| Phosphate | Metabolite | hmdb:HMDB0001429 | |
| Ceramide | Metabolite | cas:104404-17-3 | |
| SPTAN1 | GeneProduct | ensembl:ENSBTAG00000015327 | Interim Symbol: Spna1 predicted and Name: spectrin alpha 1 (predicted)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6709 |
| IL1A | GeneProduct | ensembl:ENSBTAG00000010349 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3552 |
| FAF1 | GeneProduct | ensembl:ENSBTAG00000014482 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11124 |
| CASP7 | GeneProduct | ensembl:ENSBTAG00000006615 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:840 |
| HSPB1 | GeneProduct | ensembl:ENSBTAG00000011969 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3315 |
| RIPK2 | GeneProduct | ensembl:ENSBTAG00000015271 | receptor (TNFRSF)-interacting serine-threonine kinase 2HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8767 |
| DFFB | GeneProduct | ensembl:ENSBTAG00000020015 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1677 |
| PAK1 | GeneProduct | ensembl:ENSBTAG00000010191 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5058 |
| APAF1 | GeneProduct | ensembl:ENSBTAG00000021661 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:317 |
| DAXX | GeneProduct | ensembl:ENSBTAG00000016830 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1616 |
| MAPKAPK2 | GeneProduct | ensembl:ENSBTAG00000038107 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9261 |
| CASP8 | GeneProduct | ensembl:ENSBTAG00000015718 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:841 |
| PARP1 | GeneProduct | ensembl:ENSBTAG00000000837 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:142 |
| DFFA | GeneProduct | ensembl:ENSBTAG00000013535 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1676 |
| ARHGDIB | GeneProduct | ensembl:ENSBTAG00000006039 | Interim Symbol: Arhgdib predicted and Name: Rho, GDP dissociation inhibitor (GDI) beta (predicted)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:397 |
| CYCS | GeneProduct | ensembl:ENSBTAG00000022613 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54205 |
| FASLG | GeneProduct | ensembl:ENSBTAG00000032808 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:356 |
| CASP8 | GeneProduct | ensembl:ENSBTAG00000015718 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:841 |
| FADD | GeneProduct | ensembl:ENSBTAG00000018274 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8772 |
| HSPB1 | GeneProduct | ensembl:ENSBTAG00000011969 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3315 |
| RB1 | GeneProduct | ensembl:ENSBTAG00000006640 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5925 |
| ACTA1 | GeneProduct | ensembl:ENSBTAG00000046332 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:58 |
| MAPK8 | GeneProduct | ensembl:ENSBTAG00000007876 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5599 |
| JUN | GeneProduct | ensembl:ENSBTAG00000004037 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725 |
| MAPKAPK3 | GeneProduct | ensembl:ENSBTAG00000016532 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7867 |
| MAP2K4 | GeneProduct | ensembl:ENSBTAG00000012103 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6416 |
| CASP6 | GeneProduct | ensembl:ENSBTAG00000012537 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:839 |
| HSPB1 | GeneProduct | ensembl:ENSBTAG00000011969 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3315 |
| HSPB1 | GeneProduct | ensembl:ENSBTAG00000011969 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3315 |
| APAF1 | GeneProduct | ensembl:ENSBTAG00000021661 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:317 |
| PAK2 | GeneProduct | ensembl:ENSBTAG00000047856 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5062 |
| MAP3K7 | GeneProduct | ensembl:ENSBTAG00000002625 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6885 |
| LMNB1 | GeneProduct | ensembl:ENSBTAG00000002882 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4001 |
| LMNB2 | GeneProduct | ensembl:ENSBTAG00000013624 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84823 |
| CASP9 | GeneProduct | ensembl:ENSBTAG00000002472 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:842 |
| DAXX | GeneProduct | ensembl:ENSBTAG00000016830 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1616 |
| FLIP | GeneProduct | ensembl:ENSBTAG00000010998 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8837 |
| BCL2 | GeneProduct | ensembl:ENSBTAG00000019302 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:596 |
| MAP3K1 | GeneProduct | ensembl:ENSBTAG00000013790 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4214 |
| CASP3 | GeneProduct | ensembl:ENSBTAG00000015874 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:836 |
| CASP3 | GeneProduct | ensembl:ENSBTAG00000015874 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:836 |
| HSPB1 | GeneProduct | ensembl:ENSBTAG00000011969 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3315 |
| TNF | GeneProduct | ensembl:ENSBTAG00000025471 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7124 |
| PRKDC | GeneProduct | ensembl:ENSBTAG00000017019 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5591 |
| FAF1 | GeneProduct | ensembl:ENSBTAG00000014482 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11124 |
| LMNA | GeneProduct | ensembl:ENSBTAG00000017574 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4000 |
| NFX1 | GeneProduct | ensembl:ENSBTAG00000012385 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4799 |
| HSPB1 | GeneProduct | ensembl:ENSBTAG00000011969 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3315 |
| DFFB | GeneProduct | ensembl:ENSBTAG00000020015 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1677 |
| FAS | GeneProduct | ensembl:ENSBTAG00000010785 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:355 |
| HSPB1 | GeneProduct | ensembl:ENSBTAG00000011969 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3315 |
| HSPB1 | GeneProduct | ensembl:ENSBTAG00000011969 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3315 |
| ACTB | GeneProduct | ensembl:ENSBTAG00000026199 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:60 |
| ACTG1 | GeneProduct | ensembl:ENSBTAG00000006189 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:71 |
References
- Heat shock proteins--modulators of apoptosis in tumour cells. Creagh EM, Sheehan D, Cotter TG. Leukemia. 2000 Jul;14(7):1161–73. PubMed Europe PMC Scholia
- Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres. Ji Q, Hao X, Meng Y, Zhang M, Desano J, Fan D, et al. BMC Cancer. 2008 Sep 21;8:266. PubMed Europe PMC Scholia