Glutathione metabolism (WP100)
Homo sapiens
Glutathione is a major antioxidant in all forms of life and an indicator of cellular oxidative stress. Reduction by the GSR enzyme utilizes NADPH as an electron donor. In a reduced form, glutathione is metabolized in multiple ways leading to the biosynthesis of mercapturonate, glutamate, glycine, cysteine and other amino acids. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP100 CPTAC Assay Portal]
Authors
Unknown , Thomas Kelder , Alex Pico , Andra Waagmeester , Egon Willighagen , Denise Slenter , and Kristina HanspersCited In
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Organism
Homo sapiensCommunities
Annotations
Pathway Ontology: glutathione metabolic pathway
Participants
| Label | Type | Compact Identifier | Comment |
|---|---|---|---|
| g-L-Glutamyl-L-cysteine | Metabolite | kegg.compound:C00669 | |
| L-Cysteine | Metabolite | kegg.compound:C00097 | |
| Cysteinyl-glycine | Metabolite | kegg.compound:C01419 | |
| Glycine | Metabolite | hmdb:HMDB0000123 | |
| 5-Oxoproline | Metabolite | kegg.compound:C01879 | |
| Glycine | Metabolite | hmdb:HMDB0000123 | |
| L-Glutamate | Metabolite | kegg.compound:C00025 | |
| NADPH | Metabolite | hmdb:HMDB0000221 | |
| L-Glutamate | Metabolite | kegg.compound:C00025 | |
| (5-L-Glutamyl)-L-amino acid | Metabolite | kegg.compound:C03740 | |
| R-S-Mercapturonate | Metabolite | chebi:47911 | |
| L-Amino acid | Metabolite | kegg.compound:C00151 | |
| Bis-g-glutamylcystine | Metabolite | kegg.compound:C03646 | |
| R-S-Alanine | Metabolite | kegg.compound:C05726 | |
| Glutamylcysteinyl-glycylspermidine | Metabolite | pubchem.compound:440772 | |
| NADP+ | Metabolite | hmdb:HMDB0000217 | |
| Glutathione (reduced) | Metabolite | kegg.compound:C00051 | |
| R-S-Alanylglycine | Metabolite | kegg.compound:C05729 | |
| Acetyl-CoA | Metabolite | hmdb:HMDB0001206 | |
| R-S-Glutathione | Metabolite | kegg.compound:C02320 | |
| Oxidized glutathione | Metabolite | kegg.compound:C00127 | |
| 2.3.1.80 | GeneProduct | eccode:2.3.1.80 | |
| GGTLA1 | GeneProduct | ncbigene:2687 | |
| 1.8.4.4 | GeneProduct | eccode:1.8.4.4 | |
| GGT1 | GeneProduct | ncbigene:2678 | (5-L-Glutamyl)-L-amino acid |
| GGTLA1 | GeneProduct | ncbigene:2687 | |
| 1.8.4.1 | GeneProduct | eccode:1.8.4.1 | |
| GPX1 | GeneProduct | ncbigene:2876 | |
| GSR | GeneProduct | ncbigene:2936 | |
| ANPEP | GeneProduct | ncbigene:290 | |
| 3.4.11.4 | GeneProduct | eccode:3.4.11.4 | |
| 2.3.2.4 | GeneProduct | eccode:2.3.2.4 | |
| 1.8.1.13 | GeneProduct | eccode:1.8.1.13 | |
| GSTA1 | GeneProduct | ncbigene:2938 | |
| GSTM2 | GeneProduct | ncbigene:2946 | |
| GPX2 | GeneProduct | ncbigene:2877 | |
| GSS | GeneProduct | ncbigene:2937 | |
| GCLC | GeneProduct | ncbigene:2729 | |
| GSTA5 | GeneProduct | ncbigene:221357 | |
| 1.8.4.3 | GeneProduct | eccode:1.8.4.3 | |
| IDH1 | GeneProduct | ncbigene:3417 | |
| 1.8.4.7 | GeneProduct | eccode:1.8.4.7 | |
| GGT1 | GeneProduct | ncbigene:2678 | |
| 1.8.5.1 | GeneProduct | eccode:1.8.5.1 | |
| GCLM | GeneProduct | ncbigene:2730 | |
| 1.8.4.2 | GeneProduct | eccode:1.8.4.2 | |
| GGT1 | GeneProduct | ncbigene:2678 | |
| GPX3 | GeneProduct | ncbigene:2878 | |
| 1.5.4.1 | GeneProduct | eccode:1.5.4.1 | |
| GSTT2 | GeneProduct | ncbigene:2953 | |
| 6.3.1.8 | GeneProduct | eccode:6.3.1.8 | |
| 1.1.1.43 | GeneProduct | eccode:1.1.1.43 | |
| 1.11.1.12 | GeneProduct | eccode:1.11.1.12 | |
| ANPEP | GeneProduct | ncbigene:290 | |
| OPLAH | GeneProduct | ncbigene:26873 | |
| 1.8.3.3 | GeneProduct | eccode:1.8.3.3 | |
| 2.3.2.4 | GeneProduct | eccode:2.3.2.4 | |
| GGTLA1 | GeneProduct | ncbigene:2687 | |
| GSTT1 | GeneProduct | ncbigene:2952 | |
| GPX4 | GeneProduct | ncbigene:2879 | |
| 2.8.1.3 | GeneProduct | eccode:2.8.1.3 | |
| G6PD | GeneProduct | ncbigene:2539 | |
| 3.5.1.78 | GeneProduct | eccode:3.5.1.78 | |
| GSTM1 | GeneProduct | ncbigene:2944 |