ArcPathVisio Brace Octagon Ellipse EndoplasmicReticulum HexagonPathVisio GolgiApparatus MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TrianglePathVisio none IRS2 P P P IRS1 IRS4 ATG14 PI3K complex P BECN1 BECN2 PIK3R4 NRBF2 P PIK3C3 Neuron ER Legend Microglia Anterograde cargo Microtubule TUBA1B TUBA3E TUBA3D TUBA8 TUBA4A TUBA3C TUBA1A TUBAL3 TUBA1C TUBB3 TUBB4A TUBB4B TUBB TUBB8 TUBB2B TUBB2A TUBB1 TUBB6 Defective insulin signaling Calcium overload Cell death Fragmentation Insulin resistance Gene mutated in Alzheimer's Neuronal Injury Mitochondiral dysfunction APP Intracellular domain Decreased AB clearance Neurofibrillary tangles Impaired neuronal insulin signaling Nonamyloidogenic APP processing Impairement of autophagy Decreased energy production? Reduction in LTP ULK complex ULK2 P P ULK1 ATG13 ATG101 RB1CC1 Mitochondrial dysfunction Protein oxidation Apoptosis DNA damage Inflammation Lipid peroxidation Kinesin 1 KLC3 KIF5A KIF5B KIF5C KLC1 P KLC2 KLC4 Amyloid beta beta-amyloid protein 40 beta-amyloid protein 42 ER chaperones DDIT3 XBP1 Oligomeric amyloid beta beta-amyloid protein 40 beta-amyloid protein 42 MPTP PPIF SLC25A4 SLC25A5 SLC25A6 VDAC1 VDAC2 VDAC3 SLC25A31 Antioxidant responses Amino acid metabolism DDIT3 ATP depletion Fall in mitochondrial membrane potential Increased ROS P3 peptide NO RAGE Fe2+ Apoptosis Hydrogen peroxide TNFRSF1A p50 ATF6 AGEs NAE1 NAC fragment APP Oxidative phosphorylation Calcium signaling pathway MAPT superoxide IP3 PI3P Cu+ Wnt signaling pathway Ca2+ APP intracellular domain MIR101 Induction of apoptosis Modulation of gene expression beta-amyloid protein 40 beta-amyloid protein 42 Oligomeric intracellular AB RTN3 RTN4 APBB1 GAPDH ADAM10 ADAM17 BACE1 PSENEN PSEN1 NCSTN APH1A PSEN2 APH1B IDE MME LPL APOE LRP1 FAS TNFRSF1A FADD CASP8 Cx I Cx II Cx III Cx IV Cx V APP processing HSD17B10 Degradation BID CYCS CALM1 CALM2 CALM3 CALML3 CALML5 CALML4 CALML6 P BAD PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 APAF1 CASP9 CASP3 AB Aggregation SNCA Senile plaque GPCR GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D CACNA1C CACNA1D CACNA1F CACNA1S GNAQ PLCB1 PLCB2 PLCB3 PLCB4 Aggr. amyloid TNF IL1B MAPK1 MAPK3 CASP12 Apoptosis RYR3 ATP2A2 ATP2A1 ATP2A3 EIF2AK3 ERN1 ATF6 ITPR1 ITPR2 ITPR3 Ca2+ Ca2+ ER stress CAPN1 CAPN2 CDK5R1 / p35 CDK5R1 / p25 NOS1 CDK5 P MAPT CASP3 CASP7 Paired helical filaments Neurofibrillary tangles ONOO- Based on Table 1 from Burgos et al, PLoS ONE 2014 May. miRNA differentially expressed in AD (measured in cerebrospinal fluid) MIR199B MIR381 MIR181B1 MIR124-2 MIR181D MIR124-1 MIR760 MIR184 MIR136 MIR181A1 MIR598 MIR181A2 MIR127 MIR34B MIR101-1 MIR95 MIR488 MIR138-2 MIR769 MIR218-1 MIR181B2 MIR138-1 MIR218-2 MIR495 MIR708 MIR874 MIR873 MIR129-1 MIR129-2 MIR139 MIR3200 MIR431 MIR9-1 MIR9-2 MIR9-3 MIR326 MIR377 MIR433 MIR323A MIR134 MIR329-1 MIR329-2 MIR10A MIR33B MIR410 MIR708 miRNA differentially expressed in AD (measured in blood serum) MIR219-2 MIR22 MIR125B1 MIR1307 MIR34C MIR34B MIR887 MIR182 MIR135A1 MIR135A2 MIR184 MIR127 MIR30C2 MIR873 MIR125A MIR671 MIR21 MIR1285-2 MIR375 MIR3176 MIR124-3 MIR132 MIR29A MIR29B1 MIR29C MIR124-3 MIR9-1 MIR34C MIR375 MIR138-2 MIR21 MIR138-2 MIR132 MIR21 MIR21 MIR21 MIR21 Hyperinsulinemia Sequestration of IDE Concentrated into endosome/lysosome INS INSR PPID MCU Ca2+ Ca2+ Ca2+ beta-amyloid protein 40 beta-amyloid protein 42 AKT1 AKT2 AKT3 PIK3CA PIK3R1 PIK3R2 PIK3CB PIK3CD PIK3R3 PIP3 EIF2AK2 MAPK8 MAPK9 MAPK10 GPR83 CHUK IKBKB Synaptic dysfunction Impaired memory CHRNA7 CYBB NOX1 NOX4 NFKB1 RELA (Tau-p)n NRAS KRAS HRAS RAF1 ARAF BRAF NOS2 TNF IL1A IL1B PTGS2 IL6 CSF1 DKK1 DKK2 DKK4 MTOR AMBRA1 ATG2A ATG2B WIPI1 WIPI2 PSEN1 GSK3B Ca2+ Ca2+ Axonal transport defects Wnt WNT3A WNT7A WNT11 WNT1 WNT5B WNT2 WNT2B WNT6 WNT5A WNT16 WNT4 WNT3 WNT10B WNT7B WNT10A WNT16 FZD3 FZD8 LRP5 FZD10 FZD7 FZD4 FZD1 LRP6 FZD6 FZD5 FZD9 FZD2 DVL3 FRAT1 CSNK1E DVL2 DVL1 FRAT2 TPTEP2-CSNK1E GSK3B CSNK2B CSNK2A1 CSNK2A3 CSNK2A2 APC CSNK1A1 CSNK1A1L AXIN1 AXIN2 APC2 CSNK1A1 CSNK1A1L P P P CTNNB1 PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 GSK3B sAPP alpha APP-C83 APP-C99 sAPP beta EIF2S1 ATF4 TRAF2 MAP3K5 MAP2K7 P P MAPK8 P MAPK10 P P P MAPK9 XBP1 ER chaperones ERAD Proteasome 20S catalytic core (p45) PSMA2 PSMB1 PSMA5 PSMB4 PSMB2 PSMA3 PSMA7 PSMA1 PSMB6 PSMA6 PSMB5 PSMA4 PSMB7 PSMB3 PSMA8 19S regulator PSMD8 SEM1 PSMD1 PSMC6 PSMC5 PSMC4 PSMC3 PSMC2 PSMC1 PSMD7 PSMD6 ADRM1 PSMD4 PSMD3 PSMD2 PSMD14 PSMD13 PSMD12 PSMD9 Amyloidogenic APP processing Ca2+ P P MAP2K1 P P MAP2K2 P P MAPK1 P P MAPK3 beta-amyloid protein 40 beta-amyloid protein 42 PSEN1 PSEN2 Name: Alzheimer's disease and miRNA effects Last Modified: 20240124012352 Organism: Homo sapiens