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Pathways Linkout Median Active genes Measured genes Active/Measured % Average expression over all tissues
CTGF-mediated hyperthermia resistance WP3968 7.36 1 1 100 6.20
Cytoplasmic Ribosomal Proteins WP477 6.49 74 88 84 6.62
TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc) WP2453 5.15 9 16 56 4.32
miR-517 relationship with ARCN1 and USP1 WP3596 4.86 1 5 20 4.69
TCA Cycle WP78 4.81 6 17 35 4.56
Fatty Acid Biosynthesis WP357 4.81 10 22 45 3.45
Electron Transport Chain WP111 4.7 44 103 42 4.44
Oxidative phosphorylation WP623 4.52 24 62 38 4.28
Translation Factors WP107 4.49 19 50 38 4.32
TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer WP2868 4.46 1 5 20 4.21
Fatty Acid Beta Oxidation WP143 4.42 12 34 35 3.50
IL-9 Signaling Pathway WP22 4.39 2 17 11 3.85
PDGFR-beta pathway WP3972 4.32 6 29 20 3.72
Transcription factor regulation in adipogenesis WP3599 4.28 7 22 31 2.46
Cori Cycle WP1946 4.28 7 16 43 4.11
Pilocytic astrocytoma WP2253 4.26 1 4 25 3.87
Proteasome Degradation WP183 4.25 17 63 26 4.30
Peroxisomal beta-oxidation of tetracosanoyl-CoA WP1941 4.24 0 4 0 3.83
Exercise-induced Circadian Regulation WP410 4.21 12 48 25 3.75
mir-124 predicted interactions with cell cycle and differentiation WP3595 4.21 0 6 0 3.67
Robo4 and VEGF Signaling Pathways Crosstalk WP3943 4.17 1 6 16 2.94
Butyrate-induced histone acetylation WP2366 4.11 0 2 0 3.86
Oxidative Stress WP408 4.09 11 30 36 3.75
Mitochondrial LC-Fatty Acid Beta-Oxidation WP368 4.09 5 17 29 3.66
Dopamine metabolism WP2436 4.09 3 13 23 3.49
Benzo(a)pyrene metabolism WP696 4.0 1 9 11 1.84
Glycolysis and Gluconeogenesis WP534 4.0 15 49 30 3.61
Estrogen Receptor Pathway WP2881 4.0 4 13 30 2.68
Pathogenic Escherichia coli infection WP2272 4.0 16 55 29 3.70
Serotonin Receptor 2 and STAT3 Signaling WP733 3.99 0 4 0 3.57
Leptin and adiponectin WP3934 3.95 3 10 30 3.23
IL-7 Signaling Pathway WP205 3.91 5 25 20 3.60
miR-509-3p alteration of YAP1-ECM axis WP3967 3.86 4 18 22 3.02
Hypoxia-mediated EMT and Stemness WP2943 3.86 0 2 0 3.18
Phase I biotransformations, non P450 WP136 3.82 1 8 12 3.23
NAD metabolism, sirtuins and aging WP3630 3.81 3 11 27 3.47
Photodynamic therapy-induced unfolded protein response WP3613 3.81 6 27 22 3.87
PDGF Pathway WP2526 3.81 11 39 28 3.83
Pentose Phosphate Pathway WP134 3.81 3 7 42 3.61
ApoE and miR-146 in inflammation and atherosclerosis WP3926 3.79 1 8 12 3.23
Signaling of Hepatocyte Growth Factor Receptor WP313 3.76 5 34 14 3.64
Physiological and Pathological Hypertrophy of the Heart WP1528 3.76 6 24 25 3.50
miR-222 in Exercise-Induced Cardiac Growth WP3938 3.75 1 4 25 3.35
Methylation Pathways WP704 3.7 1 9 11 3.20
mRNA Processing WP411 3.7 20 126 15 3.91
Alpha 6 Beta 4 signaling pathway WP244 3.7 8 33 24 3.31
IL-2 Signaling Pathway WP49 3.64 10 42 23 3.57
White fat cell differentiation WP3946 3.58 9 32 28 2.76
Hypothesized Pathways in Pathogenesis of Cardiovascular Disease WP3668 3.58 8 25 32 3.16
Imatinib and Chronic Myeloid Leukemia WP3640 3.58 4 21 19 3.13
IL-3 Signaling Pathway WP286 3.58 8 49 16 3.31
Nanoparticle-mediated activation of receptor signaling WP2643 3.58 3 28 10 3.28
Aryl Hydrocarbon Receptor WP2586 3.58 7 47 14 3.25
Oncostatin M Signaling Pathway WP2374 3.58 16 65 24 3.50
Human Thyroid Stimulating Hormone (TSH) signaling pathway WP2032 3.58 13 66 19 3.23
Angiogenesis WP1539 3.58 1 24 4 2.92
RalA downstream regulated genes WP2290 3.54 2 12 16 3.55
EPO Receptor Signaling WP581 3.52 2 26 7 3.33
4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression WP3879 3.52 1 18 5 3.28
Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway WP3670 3.52 3 18 16 3.06
AGE-RAGE pathway WP2324 3.52 15 66 22 3.40
Prolactin Signaling Pathway WP2037 3.52 18 76 23 3.42
Leptin signaling pathway WP2034 3.52 14 76 18 3.33
IL-5 Signaling Pathway WP127 3.52 9 40 22 3.51
Triacylglyceride Synthesis WP325 3.49 9 24 37 2.32
Nucleotide Metabolism WP404 3.46 2 19 10 3.35
IL-4 Signaling Pathway WP395 3.46 10 54 18 3.24
VEGFA-VEGFR2 Signaling Pathway WP3888 3.46 48 236 20 3.21
VEGFA VEGFR2 Signaling Pathway WP3870 3.46 45 225 20 3.23
IL-6 signaling pathway WP364 3.46 8 43 18 3.44
Photodynamic therapy-induced HIF-1 survival signaling WP3614 3.46 5 37 13 3.08
Rac1-Pak1-p38-MMP-2 pathway WP3303 3.46 11 67 16 3.16
Adipogenesis WP236 3.46 26 130 20 2.67
Folate-Alcohol and Cancer Pathway WP1589 3.46 3 8 37 2.76
Insulin signalling in human adipocytes (diabetic condition) WP3635 3.44 1 8 12 2.95
Insulin signalling in human adipocytes (normal condition) WP3634 3.44 1 8 12 2.95
Glycogen Metabolism WP500 3.39 11 38 28 3.36
p38 MAPK Signaling Pathway WP400 3.39 5 34 14 3.29
Serotonin Receptor 4-6-7 and NR3C Signaling WP734 3.32 2 19 10 3.44
Estrogen signaling pathway WP712 3.32 4 23 17 3.10
Amino Acid metabolism WP3925 3.32 19 93 20 3.24
Hepatitis C and Hepatocellular Carcinoma WP3646 3.32 7 51 13 3.18
Photodynamic therapy-induced AP-1 survival signaling. WP3611 3.32 8 50 16 2.98
NOTCH1 regulation of human endothelial cell calcification WP3413 3.32 3 17 17 2.53
Dual hijack model of Vif in HIV infection WP3300 3.32 1 8 12 3.32
Kit receptor signaling pathway WP304 3.32 8 59 13 3.18
Parkin-Ubiquitin Proteasomal System pathway WP2359 3.32 10 72 13 3.34
Interleukin-11 Signaling Pathway WP2332 3.32 5 44 11 3.23
Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway WP2203 3.32 6 47 12 3.07
Sterol Regulatory Element-Binding Proteins (SREBP) signalling WP1982 3.32 10 71 14 3.22
Osteopontin Signaling WP1434 3.32 0 13 0 3.22
Glutathione metabolism WP100 3.32 4 19 21 2.87
EGF-EGFR Signaling Pathway WP437 3.25 20 162 12 3.18
Quercetin and Nf-kB- AP-1 Induced Cell Apoptosis WP2435 3.25 4 16 25 3.26
Senescence and Autophagy in Cancer WP615 3.17 19 106 17 3.05
Notch Signaling Pathway WP61 3.17 4 61 6 3.00
MAPK Cascade WP422 3.17 2 29 6 3.11
Leptin Insulin Overlap WP3935 3.17 2 17 11 2.28
PI3K-AKT-mTOR signaling pathway and therapeutic opportunities WP3844 3.17 3 30 10 3.00
Association Between Physico-Chemical Features and Toxicity Associated Pathways WP3680 3.17 12 67 17 2.94
TGF-beta Signaling Pathway WP366 3.17 24 132 18 3.19
Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling WP3612 3.17 5 23 21 2.92
Initiation of transcription and translation elongation at the HIV-1 LTR WP3414 3.17 1 32 3 3.38
Focal Adhesion WP306 3.17 38 191 19 2.81
Transcriptional activation by NRF2 WP3 3.17 1 15 6 2.75
Selenium Metabolism and Selenoproteins WP28 3.17 9 47 19 3.33
Glycerophospholipid Biosynthetic Pathway WP2533 3.17 2 21 9 2.80
Cholesterol Biosynthesis WP197 3.17 0 15 0 3.42
Energy Metabolism WP1541 3.17 3 47 6 3.14
Selenium Micronutrient Network WP15 3.17 18 83 21 2.76
Androgen receptor signaling pathway WP138 3.17 19 90 21 3.30
SREBF and miR33 in cholesterol and lipid homeostasis WP2011 3.16 2 18 11 2.90
Prostaglandin Synthesis and Regulation WP98 3.09 7 30 23 2.45
Serotonin Receptor 2 and ELK-SRF-GATA4 signaling WP732 3.09 0 20 0 3.23
Interferon type I signaling pathways WP585 3.09 8 54 14 3.07
G13 Signaling Pathway WP524 3.09 8 38 21 3.16
TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition WP3859 3.09 1 18 5 2.97
Interactome of polycomb repressive complex 2 (PRC2) WP2916 3.09 1 16 6 3.24
Amyotrophic lateral sclerosis (ALS) WP2447 3.09 6 38 15 3.12
Hypertrophy Model WP516 3.07 3 20 15 2.75
eIF5A regulation in response to inhibition of the nuclear export system WP3302 3.07 1 4 25 3.27
Arachidonate Epoxygenase - Epoxide Hydrolase WP678 3.0 3 7 42 3.67
TGF-beta Receptor Signaling WP560 3.0 8 55 14 2.76
Insulin Signaling WP481 3.0 20 162 12 2.91
H19 action Rb-E2F1 signaling and CDK-β-catenin activity WP3969 3.0 3 15 20 3.17
Angiopoietin Like Protein 8 Regulatory Pathway WP3915 3.0 12 134 8 2.76
Canonical and Non-Canonical TGF-B signaling WP3874 3.0 1 17 5 2.60
ERK Pathway in Huntington's Disease WP3853 3.0 0 14 0 2.76
MAPK Signaling Pathway WP382 3.0 20 168 11 2.91
Amplification and Expansion of Oncogenic Pathways as Metastatic Traits WP3678 3.0 2 17 11 2.73
miR-148a-miR-31-FIH1-HIF1α-Notch signaling in glioblastoma WP3593 3.0 1 8 12 2.87
Copper homeostasis WP3286 3.0 12 55 21 2.81
Bladder Cancer WP2828 3.0 2 31 6 2.95
Common Pathways Underlying Drug Addiction WP2636 3.0 7 41 17 2.44
Primary Focal Segmental Glomerulosclerosis FSGS WP2572 3.0 16 73 21 2.81
Sulindac Metabolic Pathway WP2542 3.0 0 5 0 2.61
Corticotropin-releasing hormone signaling pathway WP2355 3.0 16 93 17 2.83
TNF alpha Signaling Pathway WP231 3.0 11 92 11 3.00
Regulation of Microtubule Cytoskeleton WP2038 3.0 3 46 6 2.89
IL-1 signaling pathway WP195 3.0 5 55 9 3.08
IL1 and megakaryocytes in obesity WP2865 2.99 5 24 20 2.90
Trans-sulfuration pathway WP2333 2.99 0 10 0 2.88
Eukaryotic Transcription Initiation WP405 2.91 2 42 4 2.92
Structural Pathway of Interleukin 1 (IL-1) WP2637 2.91 5 50 10 2.98
Integrin-mediated Cell Adhesion WP185 2.91 18 102 17 2.85
AMP-activated Protein Kinase (AMPK) Signaling WP1403 2.91 8 68 11 2.56
DNA Damage Response (only ATM dependent) WP710 2.81 14 115 12 2.75
ErbB Signaling Pathway WP673 2.81 6 55 10 2.82
Type II interferon signaling (IFNG) WP619 2.81 6 37 16 2.93
Regulation of Actin Cytoskeleton WP51 2.81 18 151 11 2.62
Kennedy pathway WP3933 2.81 0 13 0 2.67
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway WP3932 2.81 42 301 13 2.41
Valproic acid pathway WP3871 2.81 3 13 23 2.62
TLR4 Signaling and Tolerance WP3851 2.81 2 29 6 2.65
MAPK and NFkB Signalling Pathways Inhibited by Yersinia YopJ WP3849 2.81 2 12 16 2.98
Canonical and Non-canonical Notch signaling WP3845 2.81 1 29 3 2.32
BDNF-TrkB Signaling WP3676 2.81 1 33 3 2.82
Pathways Affected in Adenoid Cystic Carcinoma WP3651 2.81 4 65 6 2.77
Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation WP314 2.81 7 43 16 3.10
NLR Proteins WP288 2.81 0 9 0 2.81
Cardiac Hypertrophic Response WP2795 2.81 4 54 7 2.86
Notch Signaling Pathway WP268 2.81 1 45 2 2.72
EBV LMP1 signaling WP262 2.81 2 24 8 2.82
Nanoparticle triggered autophagic cell death WP2509 2.81 1 23 4 2.75
Brain-Derived Neurotrophic Factor (BDNF) signaling pathway WP2380 2.81 19 144 13 2.83
B Cell Receptor Signaling Pathway WP23 2.81 13 97 13 3.00
Follicle Stimulating Hormone (FSH) signaling pathway WP2035 2.81 2 27 7 3.03
RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway WP2018 2.81 6 55 10 3.00
Iron metabolism in placenta WP2007 2.81 2 12 16 2.76
Folate Metabolism WP176 2.81 10 66 15 2.31
Vitamin B12 Metabolism WP1533 2.81 7 51 13 2.14
Target Of Rapamycin (TOR) Signaling WP1471 2.81 5 36 13 2.95
ID signaling pathway WP53 2.79 0 16 0 2.77
Wnt-beta-catenin Signaling Pathway in Leukemia WP3658 2.79 2 24 8 2.55
Alanine and aspartate metabolism WP106 2.79 2 12 16 2.29
MFAP5-mediated ovarian cancer cell motility and invasiveness WP3301 2.75 2 12 16 2.63
Oxidative Damage WP3941 2.7 10 40 25 2.85
Imatinib Resistance in Chronic Myeloid Leukemia WP2946 2.7 5 50 10 2.80
Nanomaterial induced apoptosis WP2507 2.7 2 22 9 2.82
Non-homologous end joining WP438 2.66 2 8 25 2.69
Heme Biosynthesis WP561 2.58 1 9 11 2.78
Mismatch repair WP531 2.58 0 9 0 2.99
Acetylcholine Synthesis WP528 2.58 0 7 0 2.34
Endochondral Ossification WP474 2.58 10 63 15 1.91
PPAR signaling pathway WP3942 2.58 14 68 20 2.06
BMP Signaling Pathway in Eyelid Development WP3927 2.58 2 20 10 2.33
RIG-I-like Receptor Signaling WP3865 2.58 4 60 6 2.66
Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling WP3850 2.58 3 31 9 2.65
Apoptosis Modulation by HSP70 WP384 2.58 2 19 10 2.91
Regulation of Wnt-B-catenin Signaling by Small Molecule Compounds WP3664 2.58 2 17 11 2.59
Hematopoietic Stem Cell Gene Regulation by GABP alpha-beta Complex WP3657 2.58 2 20 10 2.83
Wnt Signaling Pathway Netpath WP363 2.58 7 51 13 2.80
Photodynamic therapy-induced NF-kB survival signaling WP3617 2.58 3 35 8 2.38
Synthesis and Degradation of Ketone Bodies WP311 2.58 0 5 0 2.95
DDX1 as a regulatory component of the Drosha microprocessor WP2942 2.58 1 7 14 2.90
Differentiation of white and brown adipocyte WP2895 2.58 7 25 28 1.42
Myometrial Relaxation and Contraction Pathways WP289 2.58 34 159 21 2.55
Extracellular vesicle-mediated signaling in recipient cells WP2870 2.58 3 30 10 2.75
Apoptosis WP254 2.58 11 87 12 2.61
Integrated Pancreatic Cancer Pathway WP2377 2.58 24 198 12 2.64
Signaling Pathways in Glioblastoma WP2261 2.58 6 83 7 2.89
Integrated Breast Cancer Pathway WP1984 2.58 15 167 8 2.80
PPAR Alpha Pathway WP2878 2.57 4 26 15 2.44
One Carbon Metabolism WP241 2.57 0 28 0 2.56
G Protein Signaling Pathways WP35 2.45 14 92 15 2.38
miRNA Biogenesis WP2338 2.45 0 6 0 2.81
Integrated Cancer Pathway WP1971 2.45 3 48 6 2.50
TP53 Network WP1742 2.45 3 22 13 2.40
Bone Morphogenic Protein (BMP) Signalling and Regulation WP1425 2.45 1 12 8 2.49
Inflammatory Response Pathway WP453 2.41 10 32 31 2.44
Type III interferon signaling WP2113 2.38 1 10 10 2.63
Toll-like Receptor Signaling Pathway WP75 2.32 4 103 3 2.25
DNA Damage Response WP707 2.32 5 68 7 2.56
T-Cell antigen Receptor (TCR) Signaling Pathway WP69 2.32 8 90 8 2.64
Urea cycle and metabolism of amino groups WP497 2.32 3 20 15 2.72
G1 to S cell cycle control WP45 2.32 4 68 5 2.52
Wnt Signaling Pathway WP428 2.32 6 66 9 2.10
Wnt Signaling Pathway and Pluripotency WP399 2.32 6 101 5 2.31
DNA IR-Double Strand Breaks (DSBs) and cellular response via ATM WP3959 2.32 1 56 1 2.47
TYROBP Causal Network WP3945 2.32 8 60 13 2.68
ESC Pluripotency Pathways WP3931 2.32 10 115 8 2.03
Chemokine signaling pathway WP3929 2.32 16 166 9 2.34
Mitochondrial Gene Expression WP391 2.32 0 19 0 2.69
ATM Signaling Network in Development and Disease WP3878 2.32 1 46 2 2.68
T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection WP3863 2.32 6 62 9 2.57
Toll-like Receptor Signaling WP3858 2.32 0 31 0 2.39
Cytosine methylation WP3585 2.32 1 9 11 2.38
MECP2 and Associated Rett Syndrome WP3584 2.32 8 63 12 2.31
Zinc homeostasis WP3529 2.32 3 37 8 2.24
Melatonin metabolism and effects WP3298 2.32 5 37 13 2.36
Overview of nanoparticle effects WP3287 2.32 1 19 5 2.42
Ectoderm Differentiation WP2858 2.32 7 142 4 2.09
RNA interference WP2805 2.32 0 5 0 2.68
Signal Transduction of S1P Receptor WP26 2.32 4 25 16 2.51
Trans-sulfuration and one carbon metabolism WP2525 2.32 2 31 6 2.53
Nanoparticle triggered regulated necrosis WP2513 2.32 2 11 18 2.66
Spinal Cord Injury WP2431 2.32 29 117 24 2.28
Gastric Cancer Network 2 WP2363 2.32 3 32 9 2.80
Endothelin Pathways WP2197 2.32 6 33 18 2.17
IL17 signaling pathway WP2112 2.32 3 31 9 2.62
Apoptosis Modulation and Signaling WP1772 2.32 11 94 11 2.64
Nuclear Receptors WP170 2.32 2 38 5 2.17
MicroRNAs in cardiomyocyte hypertrophy WP1544 2.32 6 105 5 2.17
Regulation of toll-like receptor signaling pathway WP1449 2.32 4 147 2 2.30
Complement and Coagulation Cascades WP558 2.29 13 58 22 2.14
Tryptophan metabolism WP465 2.29 11 46 23 2.35
Aryl Hydrocarbon Receptor Pathway WP2873 2.29 8 46 17 2.28
Type II diabetes mellitus WP1584 2.29 1 22 4 1.98
NAD+ metabolism WP3644 2.16 0 16 0 2.30
Lung fibrosis WP3624 2.16 6 64 9 1.80
Retinoblastoma (RB) in Cancer WP2446 2.16 4 90 4 2.67
Sphingolipid Metabolism WP1422 2.16 3 20 15 2.70
Catalytic cycle of mammalian Flavin-containing MonoOxygenases (FMOs) WP688 2.0 1 5 20 1.60
DNA Replication WP466 2.0 2 42 4 2.34
GPR40 Pathway WP3958 2.0 0 15 0 1.97
Microglia Pathogen Phagocytosis Pathway WP3937 2.0 4 40 10 2.58
Hfe effect on hepcidin production WP3924 2.0 0 7 0 1.57
BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation WP3876 2.0 4 13 30 2.45
NAD+ biosynthetic pathways WP3645 2.0 0 22 0 2.38
Mesodermal Commitment Pathway WP2857 2.0 7 153 4 2.00
Endoderm Differentiation WP2853 2.0 6 145 4 2.10
T-Cell Receptor and Co-stimulatory Signaling WP2583 2.0 2 29 6 2.59
ATM Signaling Pathway WP2516 2.0 2 41 4 2.43
One carbon donor WP2190 2.0 0 1 0 2.34
SRF and miRs in Smooth Muscle Differentiation and Proliferation WP1991 2.0 1 17 5 1.95
Homologous recombination WP186 2.0 0 13 0 2.24
Cell Cycle WP179 2.0 8 103 7 2.50
Heart Development WP1591 2.0 4 47 8 1.55
Nucleotide-binding Oligomerization Domain (NOD) pathway WP1433 2.0 3 41 7 2.14
Composition of Lipid Particles WP3601 1.95 2 10 20 1.14
Oxytocin signaling WP2889 1.95 0 4 0 2.00
Hair Follicle Development: Induction (Part 1 of 3) WP2804 1.95 3 42 7 1.92
Eicosanoid Synthesis WP167 1.95 2 20 10 1.94
Benzene metabolism WP3891 1.92 1 6 16 1.24
Amino acid conjugation of benzoic acid WP521 1.8 1 4 25 0.61
Liver X Receptor Pathway WP2874 1.79 2 10 20 1.50
NAD Biosynthesis II (from tryptophan) WP2485 1.79 0 8 0 1.85
Fluoropyrimidine Activity WP1601 1.79 2 34 5 2.18
Ganglio Sphingolipid Metabolism WP1423 1.79 0 18 0 1.35
Osteoclast Signaling WP12 1.79 2 16 12 2.01
Influenza A virus infection WP1438 1.66 0 2 0 1.52
Vitamin A and Carotenoid Metabolism WP716 1.58 7 43 16 1.23
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways WP706 1.58 25 166 15 1.81
Complement Activation WP545 1.58 7 22 31 1.75
Calcium Regulation in the Cardiac Cell WP536 1.58 29 153 18 1.76
Statin Pathway WP430 1.58 4 31 12 1.41
Simplified Depiction of MYD88 Distinct Input-Output Pathway WP3877 1.58 1 18 5 2.11
ATR Signaling WP3875 1.58 0 8 0 2.16
Cell-type Dependent Selectivity of CCK2R Signaling WP3679 1.58 1 13 7 1.06
Interleukin-1 Induced Activation of NF-kappa-B WP3656 1.58 0 9 0 2.43
miRNA targets in ECM and membrane receptors WP2911 1.58 13 43 30 1.40
NRF2 pathway WP2884 1.58 15 141 10 1.88
Small Ligand GPCRs WP247 1.58 1 19 5 1.01
Histone Modifications WP2369 1.58 3 66 4 1.84
Allograft Rejection WP2328 1.58 13 96 13 1.93
Deregulation of Rab and Rab Effector Genes in Bladder Cancer WP2291 1.58 0 16 0 1.70
Glial Cell Differentiation WP2276 1.58 1 8 12 1.67
Synaptic Vesicle Pathway WP2267 1.58 3 51 5 1.34
TarBasePathway WP1992 1.58 2 17 11 0.90
miRNA Regulation of DNA Damage Response WP1530 1.58 6 90 6 2.05
Globo Sphingolipid Metabolism WP1424 1.58 0 22 0 1.48
Evolocumab Mechanism WP3408 1.57 0 2 0 1.84
Proprotein convertase subtilisin-kexin type 9 (PCSK9) mediated LDL receptor degradation WP2846 1.57 0 2 0 1.84
Gene regulatory network modelling somitogenesis WP2854 1.35 0 12 0 1.05
Effects of Nitric Oxide WP1995 1.35 2 8 25 1.10
Hedgehog Signaling Pathway WP47 1.29 1 16 6 1.51
Wnt Signaling in Kidney Disease WP3939 1.29 2 36 5 1.38
LncRNA-mediated mechanisms of therapeutic resistance WP3672 1.29 0 12 0 1.40
Gastric Cancer Network 1 WP2361 1.29 1 28 3 1.89
Arrhythmogenic Right Ventricular Cardiomyopathy WP2118 1.29 12 74 16 1.72
mir34a and TGIF2 in osteoclastogenesis WP2866 1.16 0 2 0 1.57
EV release from cardiac cells and their functional effects WP3297 1.04 2 10 20 1.11
ACE Inhibitor Pathway WP554 1.0 1 17 5 1.00
Development of pulmonary dendritic cells and macrophage subsets WP3892 1.0 0 13 0 1.74
Osteoblast Signaling WP322 1.0 2 14 14 1.05
Neural Crest Differentiation WP2064 1.0 6 101 5 1.24
miRs in Muscle Cell Differentiation WP2012 1.0 2 39 5 1.49
Serotonin Transporter Activity WP1455 1.0 2 11 18 1.82
Polyol Pathway WP690 0.97 0 4 0 2.26
Hematopoietic Stem Cell Differentiation WP2849 0.97 1 48 2 1.04
FTO Obesity Variant Mechanism WP3407 0.89 0 8 0 0.87
Differentiation Pathway WP2848 0.85 0 50 0 0.80
GPCRs, Class B Secretin-like WP334 0.84 2 24 8 0.52
Irinotecan Pathway WP229 0.84 1 14 7 1.60
Constitutive Androstane Receptor Pathway WP2875 0.73 2 32 6 1.41
EDA Signalling in Hair Follicle Development WP3930 0.68 0 13 0 0.82
Ovarian Infertility Genes WP34 0.68 3 32 9 1.56
Vitamin D Metabolism WP1531 0.68 0 11 0 1.69
Parkinsons Disease Pathway WP2371 0.63 4 70 5 0.53
Sulfation Biotransformation Reaction WP692 0.6 0 18 0 0.82
Cytokines and Inflammatory Response WP530 0.59 2 26 7 0.70
Striated Muscle Contraction WP383 0.59 8 38 21 1.17
Preimplantation Embryo WP3527 0.58 7 59 11 0.96
Matrix Metalloproteinases WP129 0.58 6 31 19 0.70
Monoamine Transport WP727 0.49 1 33 3 0.86
Serotonin and anxiety WP3947 0.49 1 17 5 0.37
Development and heterogeneity of the ILC family WP3893 0.49 0 32 0 0.74
Fatty Acid Omega Oxidation WP206 0.47 3 16 18 0.70
Hypothetical Craniofacial Development Pathway WP3655 0.46 1 8 12 1.37
Nucleotide GPCRs WP80 0.38 0 11 0 0.63
Metapathway biotransformation WP702 0.38 8 179 4 0.77
Nuclear Receptors in Lipid Metabolism and Toxicity WP299 0.38 1 36 2 0.67
Farnesoid X Receptor Pathway WP2879 0.38 1 19 5 0.51
Drug Induction of Bile Acid Pathway WP2289 0.38 0 17 0 0.68
Codeine and Morphine Metabolism WP1604 0.38 0 9 0 0.90
Nicotine Activity on Dopaminergic Neurons WP1602 0.38 3 21 14 0.54
Nicotine Metabolism WP1600 0.34 1 6 16 0.50
Hypothetical Network for Drug Addiction WP666 0.32 0 32 0 0.64
Blood Clotting Cascade WP272 0.32 1 22 4 0.70
Nicotine Activity on Chromaffin Cells WP1603 0.32 0 4 0 0.36
Aflatoxin B1 metabolism WP699 0.26 1 7 14 1.16
Glucose Homeostasis WP661 0.26 0 1 0 0.49
Biogenic Amine Synthesis WP550 0.26 1 15 6 0.26
Colchicine Metabolic Pathway WP2536 0.26 0 1 0 1.13
Cardiac Progenitor Differentiation WP2406 0.26 1 53 1 0.57
Estrogen metabolism WP697 0.2 0 18 0 0.88
Caffeine and Theobromine metabolism WP3633 0.2 0 4 0 0.57
Dopaminergic Neurogenesis WP2855 0.2 2 30 6 0.17
Felbamate Metabolism WP2816 0.2 0 2 0 0.98
Peptide GPCRs WP24 0.2 0 74 0 0.24
Arylamine metabolism WP694 0.14 0 7 0 0.68
Tamoxifen metabolism WP691 0.14 0 21 0 0.57
Monoamine GPCRs WP58 0.14 0 33 0 0.22
GPCRs, Class A Rhodopsin-like WP455 0.14 1 257 0 0.12
Oxidation by Cytochrome P450 WP43 0.14 1 63 1 0.48
Tgif disruption of Shh signaling WP3674 0.14 0 9 0 0.59
Gut-Liver Indole Metabolism WP3627 0.14 0 1 0 0.83
Glucocorticoid & Mineralcorticoid Metabolism WP237 0.14 0 8 0 0.56
Alzheimers Disease WP2059 0.14 15 145 10 0.35
Lidocaine metabolism WP2646 0.13 0 2 0 0.72
Steroid Biosynthesis WP496 0.07 0 10 0 0.39
Diclofenac Metabolic Pathway WP2491 0.07 0 4 0 0.55
Thyroxine (Thyroid Hormone) Production WP1981 0.07 0 6 0 0.27
Amino acid conjugation WP715 0.0 0 0 0 0.00
Glucuronidation WP698 0.0 2 26 7 0.45
GPCRs, Class C Metabotropic glutamate, pheromone WP501 0.0 0 15 0 0.17
Role of Osx and miRNAs in tooth development WP3971 0.0 2 34 5 0.03
Cocaine metabolism WP2826 0.0 0 0 0 0.00
Secretion of Hydrochloric Acid in Parietal Cells WP2597 0.0 0 5 0 0.21
Gastric acid production WP2596 0.0 0 7 0 0.27
Phospholipid biosynthesis WP2457 0.0 0 0 0 0.00
HIF1A and PPARG regulation of glycolysis WP2456 0.0 0 0 0 0.00
Metastatic brain tumor WP2249 0.0 2 27 7 0.00
Cell Differentiation - Index WP2029 0.0 0 54 0 0.00
miRNAs involved in DNA damage response WP1545 0.0 3 68 4 0.01
GPCRs, Other WP117 0.0 2 97 2 0.18
Highlighting legend
  • Active gene (expression > 5)
  • Not-active gene (expression < 5)
Selected pathway: Fatty Acid Biosynthesis
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