TCA Cycle (Homo sapiens)

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Description

The citric acid cycle, also known as the tricarboxylic acid cycle (TCA cycle) or the Krebs cycle, (or rarely, the Szent-Gyorgyi-Krebs cycle) is a series of enzyme-catalysed chemical reactions of central importance in all living cells that use oxygen as part of cellular respiration. In eukaryotes, the citric acid cycle occurs in the matrix of the mitochondrion. The components and reactions of the citric acid cycle were established by seminal work from both Albert Szent-Gyorgyi and Hans Krebs. Source: Wikipedia (wikipedia:citric_acid_cycle)

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Bibliography

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  1. Lambeth DO, Tews KN, Adkins S, Frohlich D, Milavetz BI; ''Expression of two succinyl-CoA synthetases with different nucleotide specificities in mammalian tissues.''; J Biol Chem, 2004 PubMed
  2. Des Rosiers C, Di Donato L, Comte B, Laplante A, Marcoux C, David F, Fernandez CA, Brunengraber H; ''Isotopomer analysis of citric acid cycle and gluconeogenesis in rat liver. Reversibility of isocitrate dehydrogenase and involvement of ATP-citrate lyase in gluconeogenesis.''; J Biol Chem, 1995 PubMed
  3. Greksák M, Lopes-Cardozo M, van den Bergh SG; ''Citrate synthesis in intact rat-liver mitochondria is irreversible.''; Eur J Biochem, 1982 PubMed
  4. Johnson JD, Muhonen WW, Lambeth DO; ''Characterization of the ATP- and GTP-specific succinyl-CoA synthetases in pigeon. The enzymes incorporate the same alpha-subunit.''; J Biol Chem, 1998 PubMed
  5. Krebs, H. A., Johnson, W. A.; ''The Role of Citric Acid in Intermediate Metabolism in Animal Tissues.''; Enzymologia, 1937
  6. Sazanov LA, Jackson JB; ''Proton-translocating transhydrogenase and NAD- and NADP-linked isocitrate dehydrogenases operate in a substrate cycle which contributes to fine regulation of the tricarboxylic acid cycle activity in mitochondria.''; FEBS Lett, 1994 PubMed
  7. Hoek JB, Rydström J; ''Physiological roles of nicotinamide nucleotide transhydrogenase.''; Biochem J, 1988 PubMed
  8. Gabriel JL, Zervos PR, Plaut GW; ''Activity of purified NAD-specific isocitrate dehydrogenase at modulator and substrate concentrations approximating conditions in mitochondria.''; Metabolism, 1986 PubMed
  9. Fernandez CA, Des Rosiers C; ''Modeling of liver citric acid cycle and gluconeogenesis based on 13C mass isotopomer distribution analysis of intermediates.''; J Biol Chem, 1995 PubMed
  10. Comte B, Vincent G, Bouchard B, Benderdour M, Des Rosiers C; ''Reverse flux through cardiac NADP(+)-isocitrate dehydrogenase under normoxia and ischemia.''; Am J Physiol Heart Circ Physiol, 2002 PubMed
  11. Liu TC, Kim H, Arizmendi C, Kitano A, Patel MS; ''Identification of two missense mutations in a dihydrolipoamide dehydrogenase-deficient patient.''; Proc Natl Acad Sci U S A, 1993 PubMed
  12. Sheu KF, Blass JP; ''The alpha-ketoglutarate dehydrogenase complex.''; Ann N Y Acad Sci, 1999 PubMed
  13. Krebs HA, Holzach O; ''The conversion of citrate into cis-aconitate and isocitrate in the presence of aconitase.''; Biochem J, 1952 PubMed
  14. Des Rosiers C, Fernandez CA, David F, Brunengraber H; ''Reversibility of the mitochondrial isocitrate dehydrogenase reaction in the perfused rat liver. Evidence from isotopomer analysis of citric acid cycle intermediates.''; J Biol Chem, 1994 PubMed
  15. Lawson AM, Chalmers RA, Watts RW; ''Urinary organic acids in man. I. Normal patterns.''; Clin Chem, 1976 PubMed

History

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CompareRevisionActionTimeUserComment
70014view23:48, 11 July 2013MaintBotupdated to 2013 schema
67690view11:49, 26 June 2013DdiglesOntology Term : 'citrate cycle pathway' added !
59783view22:02, 7 March 2013Khanspersminor change
59770view17:53, 7 March 2013Khanspersminor layout change
59769view17:51, 7 March 2013Khanspersadded bounding rectangle to pathway nodes
59710view19:48, 6 March 2013AlexanderPicoSimplified SUCLG reaction; additional minor layout and label fixes
59709view19:22, 6 March 2013AlexanderPicoPeriodical save, work in progress
59708view19:17, 6 March 2013AlexanderPicoRemoved incomplete H+ accounting
59707view19:13, 6 March 2013AlexanderPicoFixing layout, labels, node size, arrows
47741view15:54, 5 April 2012MdstobbeMinor layout change.
47740view15:50, 5 April 2012MdstobbeChanged to Entrez Gene IDs.
47731view16:50, 4 April 2012MdstobbeAdded 3 more literature references.
47724view11:56, 4 April 2012MdstobbePeriodical save, work in progress
47723view11:46, 4 April 2012MdstobbePeriodical save, work in progress
47722view11:36, 4 April 2012MdstobbePeriodical save, work in progress
47721view11:26, 4 April 2012MdstobbePeriodical save, work in progress
47720view11:16, 4 April 2012MdstobbePeriodical save, work in progress
47700view09:15, 3 April 2012MdstobbePeriodical save, work in progress
47699view09:03, 3 April 2012MdstobbePeriodical save, work in progress
47698view08:53, 3 April 2012MdstobbePeriodical save, work in progress
47697view08:41, 3 April 2012MdstobbePeriodical save, work in progress
47696view08:20, 3 April 2012MdstobbePeriodical save, work in progress
47695view08:10, 3 April 2012MdstobbePeriodical save, work in progress
47694view08:00, 3 April 2012MdstobbePeriodical save, work in progress
47681view21:31, 2 April 2012Mdstobbesmall change to lit. ref.
47680view21:26, 2 April 2012MdstobbeAdded reference and switched the two IDH reactions from place.
47679view21:06, 2 April 2012MdstobbePeriodical save, work in progress
47654view16:37, 2 April 2012SmhoutenRefinements
47580view14:58, 29 March 2012MdstobbeAdded literature references
47579view14:54, 29 March 2012MdstobbePeriodical save, work in progress
47578view14:34, 29 March 2012MdstobbePeriodical save, work in progress
47577view14:24, 29 March 2012MdstobbePeriodical save, work in progress
47576view14:23, 29 March 2012MdstobbeLayout
47575view14:14, 29 March 2012MdstobbePeriodical save, work in progress
47473view21:39, 20 March 2012MdstobbePeriodical save, work in progress
47472view21:29, 20 March 2012MdstobbePeriodical save, work in progress
47471view21:19, 20 March 2012MdstobbePeriodical save, work in progress
47470view21:09, 20 March 2012MdstobbePeriodical save, work in progress
47469view20:59, 20 March 2012MdstobbePeriodical save, work in progress
47452view22:45, 19 March 2012MdstobbeCorrected directions
47451view22:28, 19 March 2012MdstobbeAdded IDs
47407view17:08, 18 March 2012MdstobbePeriodical save, work in progress
47406view16:33, 18 March 2012MdstobbeAdded cosubstrates and removed reactions that are not part of the TCA cycle. Furthermore, enzymes were corrected where necessary.
47405view16:29, 18 March 2012MdstobbePeriodical save, work in progress
47404view16:19, 18 March 2012MdstobbePeriodical save, work in progress
47403view16:00, 18 March 2012MdstobbePeriodical save, work in progress
47402view15:30, 18 March 2012MdstobbePeriodical save, work in progress
47401view15:19, 18 March 2012MdstobbePeriodical save, work in progress
47400view15:05, 18 March 2012MdstobbePeriodical save, work in progress
47399view14:45, 18 March 2012MdstobbePeriodical save, work in progress

External references

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NameTypeDatabase referenceComment
Electron Transport ChainPathwayWP111 (WikiPathways)
GTPMetaboliteHMDB01273 (HMDB) The ChEBI ID with the correct charge is: 37565
GDPMetaboliteHMDB01201 (HMDB) The ChEBI ID with the correct charge is: 58189
CoAMetaboliteHMDB01423 (HMDB) The ChEBI ID with the correct charge is: 57287
CO2MetaboliteHMDB01967 (HMDB)
citrateMetaboliteHMDB00094 (HMDB)
waterMetaboliteHMDB02111 (HMDB)
NADMetaboliteHMDB00902 (HMDB)
NADHMetaboliteHMDB01487 (HMDB) The ChEBI ID with the correct charge is: 57945
ubiquinol-10MetaboliteHMDB13111 (HMDB)
FHGeneProduct2271 (Entrez Gene)
fumarateMetaboliteHMDB00134 (HMDB)
SDHCGeneProduct6391 (Entrez Gene)
succinateMetaboliteHMDB00254 (HMDB) The ChEBI ID with the correct charge is: 30031
D-threo-IsocitrateMetaboliteHMDB00193 (HMDB) The ChEBI ID with the correct charge is: 15562
Degradation of Fatty AcidsPathwayWP143 (WikiPathways)
succinyl-CoAMetaboliteHMDB01022 (HMDB) The ChEBI ID with the correct charge is: 57292
NADPMetaboliteHMDB00217 (HMDB)
2-oxoglutarateMetaboliteHMDB00208 (HMDB)
ATPMetaboliteHMDB00538 (HMDB) The ChEBI ID with the correct charge is: 30616
SUCLG2GeneProduct8801 (Entrez Gene)
Metabolism of amino acidsPathwayWP1847 (WikiPathways) Not all metabolic pathways of amino acids are connected to the TCa cycle.
CSGeneProduct1431 (Entrez Gene)
oxaloacetateMetaboliteHMDB00223 (HMDB)
DLDGeneProduct1738 (Entrez Gene)
SDHDGeneProduct6392 (Entrez Gene)
DLSTGeneProduct1743 (Entrez Gene)
ACO2GeneProduct50 (Entrez Gene)
acetyl-CoAMetaboliteHMDB01206 (HMDB) The ChEBI ID with the correct charge is: 57288
SDHBGeneProduct6390 (Entrez Gene)
IDH3BGeneProduct3420 (Entrez Gene)
Fatty Acid SynthesisPathwayWP357 (WikiPathways)
IDH3AGeneProduct3419 (Entrez Gene)
cis-aconitateMetaboliteHMDB00072 (HMDB) The ChEBI ID with the correct charge is: 16383
SUCLG1GeneProduct8802 (Entrez Gene)
IDH2GeneProduct3418 (Entrez Gene)
SDHAGeneProduct6389 (Entrez Gene)
NADPHMetaboliteHMDB00221 (HMDB) The ChEBI ID with the correct charge is: 57783
MDH2GeneProduct4191 (Entrez Gene)
ADPMetaboliteHMDB01341 (HMDB) The ChEBI ID with the correct charge is: 456216
IDH3GGeneProduct3421 (Entrez Gene)
ubiquinone-10MetaboliteHMDB01072 (HMDB)
OGDHGeneProduct4967 (Entrez Gene)
Glucose metabolismPathwayWP534 (WikiPathways)
(S)-malateMetaboliteHMDB00156 (HMDB)
PiMetaboliteHMDB01429 (HMDB)
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