Wnt Signaling Pathway and Pluripotency (Mus musculus)
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Description
This pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluripotency and self-renewal. A central organizing theme of this pathway are known drug targets which promote self-renewal or pluripotency (BIO and IQ-1) and implicated upstream regulators of the core pluripotency transcriptional components (e.g. Nanog). It should be noted that it is unclear whether all the depicted components participate in this pathway in human embryonic stem cells. Interactions and object/gene groups for the pathway exist for the majority of components.
Bibliography
- Sato N, Brivanlou AH; ''Manipulation of self-renewal in human embryonic stem cells through a novel pharmacological GSK-3 inhibitor.; ''Methods Mol Biol, 2006 - PubMed
- Pereira L, Yi F, Merrill BJ; ''Repression of Nanog gene transcription by Tcf3 limits embryonic stem cell self-renewal.; ''Mol Cell Biol, 2006 - PubMed
- ''Kegg version of this pathway; ''http://www.genome.jp/kegg/pathway/hsa/hsa04310.html,
- Miyabayashi T, Teo JL, Yamamoto M, McMillan M, Nguyen C, Kahn M; ''Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency.; ''Proc Natl Acad Sci U S A, 2007 - PubMed
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Pathway Info
DataNodes
| View all 98 DataNodes |
| Name | Type | Backpage Header | Database reference |
|---|---|---|---|
| Tcf3 | GeneProduct | Tcf3 | 21415 (Entrez Gene) |
| Nanog | GeneProduct | LOC100038891 | 71950 (Entrez Gene) |
| Wnt2 | GeneProduct | Wnt2 | 22413 (Entrez Gene) |
| Nkd1 | GeneProduct | Nkd1 | 93960 (Entrez Gene) |
| Wnt2b | GeneProduct | Wnt2b | 22414 (Entrez Gene) |
