From WikiPathways
Curation Tags
Description
This pathway is about carotenoid metabolism. It is mainly created by the NuGO focusteam on Carotenoid metabolism. Finally it was subject to a text mining workflow which added some additional entities.
Bibliography
- Micozzi MS, Brown ED, Edwards BK, Bieri JG, Taylor PR, Khachik F, Beecher GR, Smith JC Jr; ''Plasma carotenoid response to chronic intake of selected foods and beta-carotene supplements in men.; ''Am J Clin Nutr, 1992 - PubMed
- Handelman GJ, Dratz EA, Reay CC, van Kuijk JG; ''Carotenoids in the human macula and whole retina.; ''Invest Ophthalmol Vis Sci, 1988 - PubMed
- Khachik F, Beecher GR, Goli MB, Lusby WR, Smith JC Jr; ''Separation and identification of carotenoids and their oxidation products in the extracts of human plasma.; ''Anal Chem, 1992 - PubMed
- Huet F, Semama D, Maingueneau C, Charavel A, Nivelon JL; ''Vitamin A deficiency and nocturnal vision in teenagers with cystic fibrosis.; ''Eur J Pediatr, 1997 - PubMed
- Johansson S, Melhus H; ''Vitamin A antagonizes calcium response to vitamin D in man.; ''J Bone Miner Res, 2001 - PubMed
- Amir H, Karas M, Giat J, Danilenko M, Levy R, Yermiahu T, Levy J, Sharoni Y; ''Lycopene and 1,25-dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells.; ''Nutr Cancer, 1999 - PubMed
- Sies H, Stahl W, Sundquist AR; ''Antioxidant functions of vitamins. Vitamins E and C, beta-carotene, and other carotenoids.; ''Ann N Y Acad Sci, 1992 - PubMed
- Balmer JE, Blomhoff R; ''Gene expression regulation by retinoic acid.; ''J Lipid Res, 2002 - PubMed
- VandenLangenberg GM, Brady WE, Nebeling LC, Block G, Forman M, Bowen PE, Stacewicz-Sapuntzakis M, Mares-Perlman JA; ''Influence of using different sources of carotenoid data in epidemiologic studies.; ''J Am Diet Assoc, 1996 - PubMed
- Waagmeester A, Pezik P, Coort S, Tourniaire F, Evelo C, Rebholz-Schuhmann D; ''Pathway enrichment based on text mining and its validation on carotenoid and vitamin A metabolism.; ''OMICS, 2009 - PubMed
- Boosalis MG, Snowdon DA, Tully CL, Gross MD; ''Acute phase response and plasma carotenoid concentrations in older women: findings from the nun study.; ''Nutrition, 1996 - PubMed
- Ruhl CE, Everhart JE; ''Relation of elevated serum alanine aminotransferase activity with iron and antioxidant levels in the United States.; ''Gastroenterology, 2003 - PubMed
- Czeczuga-Semeniuk E, Wolczynski S, Markiewicz W; ''Preliminary identification of carotenoids in malignant and benign neoplasms of the breast and surrounding fatty tissue.; ''Neoplasma, 2003 - PubMed
- Bendich A, Olson JA; ''Biological actions of carotenoids.; ''FASEB J, 1989 - PubMed
- Torma H, Rollman O, Binderup L, Michaelsson G; ''Vitamin D analogs affect the uptake and metabolism of retinol by human epidermal keratinocytes in culture.; ''J Investig Dermatol Symp Proc, 1996 - PubMed
- Olmedilla B, Granado F, Blanco I, Rojas-Hidalgo E; ''Seasonal and sex-related variations in six serum carotenoids, retinol, and alpha-tocopherol.; ''Am J Clin Nutr, 1994 - PubMed
- Hidiroglou M, Williams CJ; ''Interrelationships among liposoluble vitamins in ruminants.; ''Am J Vet Res, 1986 - PubMed
Categories
History
Pathway Info
DataNodes
| Name
| Type
| Backpage Header
| Database reference
| | Rbp4 | GeneProduct | Retinol binding protein 4, plasma | 5950 (Entrez Gene) |
| Rdh8 | Unknown | Retinol dehydrogenase 8 | 50700 (Entrez Gene) |
| beta-cryptoxanthin | Metabolite | beta-cryptoxanthin | HMDB02268 (hmdbid) |
| RARg | Unknown | RARg | 5916 (Entrez Gene) |
| Sult2b1 | Unknown | Sult2b1 | 6820 (Entrez Gene) |
| Aldh1a2 | GeneProduct | Aldehyde dehydrogenase family 1, subfamily A2 | 8854 (Entrez Gene) |
| RARa | Unknown | RARa | 5914 (Entrez Gene) |
| Npc1l1 | Unknown | Npc1l1 | 29881 (Entrez Gene) |
| Rlbp1 | Unknown | | 6017 (Entrez Gene) |
| RXRa | Unknown | RXRa | 6256 (Entrez Gene) |
| astaxanthin | Metabolite | astaxanthin | HMDB02204 (hmdbid) |
| Rbp7 | GeneProduct | Retinol binding protein 7, cellular | 116362 (Entrez Gene) |
| lycopene | Metabolite | lycopene | HMDB03000 (hmdbid) |
| Abcg5 | Unknown | Abcg5 | 64240 (Entrez Gene) |
| Rbp1 | GeneProduct | Retinol binding protein 1, cellular | 5947 (Entrez Gene) |
| Cd36 | Unknown | Cd36 | 948 (Entrez Gene) |
| Bcmo1 | Unknown | Bcmo1 | 53630 (Entrez Gene) |
| Rdh10 | Unknown | Retinol dehydrogenase 10 | 157506 (Entrez Gene) |
| Rpe65 | Unknown | | 6121 (RefSeq) |
| Rbp2 | GeneProduct | Retinol binding protein 2, cellular | 5948 (Entrez Gene) |
| Retsat | GeneProduct | All-trans-retinol 13,14-reductase | 54884 (Entrez Gene) |
| Aldh1a1 | GeneProduct | Aldehyde dehydrogenase family 1, subfamily A1 | 216 (Entrez Gene) |
| zeaxanthin | Metabolite | zeaxanthin | HMDB02789 (hmdbid) |
| Adh4 | GeneProduct | Alcohol dehydrogenase 4 (class II), pi polypeptide | 127 (Entrez Gene) |
| lutein | Metabolite | lutein | HMDB03233 (hmdbid) |
| Rdh12 | Unknown | | 145226 (Entrez Gene) |
| Scarb1 | Unknown | SRB1 | 949 (Entrez Gene) |
| RXRg | Unknown | RXRg | 6258 (Entrez Gene) |
| Scarb1 | Unknown | SRB1 | NP_058021 (RefSeq) |
| Lpl | Unknown | Lpl | 4023 (Entrez Gene) |
| Cyp26b1 | Unknown | Cyp26b1 | 56603 (Entrez Gene) |
| Abcg8 | Unknown | Abcg8 | 64241 (Entrez Gene) |
| Cyp26a1 | Unknown | Cytochrome P450 26A1 | 1592 (Entrez Gene) |
| Bcdo2 | GeneProduct | Beta-carotene 9', 10'-dioxygenase 2 | NP_573480 (RefSeq) |
| Rdh5 | GeneProduct | Retinol dehydrogenase 5 | 5959 (Entrez Gene) |
| RXRb | Unknown | RXRb | 6257 (Entrez Gene) |
| ARAT | GeneProduct | | (Entrez Gene) |
| Adh1 | GeneProduct | Alcohol dehydrogenase 1 (class I) | 124 (Entrez Gene) |
| RARb | Unknown | RARb | 5915 (Entrez Gene) |
| Crabp1 | GeneProduct | Cellular retinoic acid binding protein I | 1381 (Entrez Gene) |
| Bcmo1 | GeneProduct | Beta-carotene 15,15'-monooxygenase | NP_067461 (RefSeq) |
| Lrat | GeneProduct | Lecithin-retinol acyltransferase | 9227 (Entrez Gene) |
| alpha-carotene | Metabolite | alpha-carotene | HMDB03993 (hmdbid) |
| Aldh1a3 | Unknown | | 220 (Entrez Gene) |
| violaxanthin | Metabolite | violaxanthin | HMDB03101 (hmdbid) |
| Sult1a1 | Unknown | Sult1a1 | 6817 (Entrez Gene) |
| cryptoxanthin | Metabolite | cryptoxanthin | HMDB02268 (hmdbid) |
| Crabp2 | GeneProduct | Cellular retinoic acid binding protein II | 1382 (Entrez Gene) |
| canthaxanthin | Metabolite | canthaxanthin | HMDB03154 (hmdbid) |
| Cyp2e1 | Unknown | Cyp2e1 | 1571 (Entrez Gene) |
| Vitamin D3 | Metabolite | Vitamin D3 | HMDB00876 (hmdbid) |
| Dhrs3 | GeneProduct | Dehydrogenase/reductase (SDR family) member 3 | 9249 (Entrez Gene) |
| MAPK | GeneProduct | MAPK | 2.7.11.24 (enzyme) |