Estrogen signaling pathway (Homo sapiens)

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Description

Estrogen receptor refers to a group of receptors which are activated by the hormone 17-beta-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. The main function of the estrogen receptor is as a DNA binding transcription factor which regulates gene expression. However the estrogen receptor also has additional functions independent of DNA binding.

Ontology Tags

 

Bibliography

  1. Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, Ninomiya-Tsuji J; ''TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.''; J Biol Chem, 2006 PubMed
  2. Battaglia F, Delfino S, Merello E, Puppo M, Piva R, Varesio L, Bosco MC; ''Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB.''; J Leukoc Biol, 2008 PubMed
  3. Song YJ, Jen KY, Soni V, Kieff E, Cahir-McFarland E; ''IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation.''; Proc Natl Acad Sci U S A, 2006 PubMed

History

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CompareRevisionActionTimeUserComment
77341view19:19, 22 August 2014AlexanderPicoModified description
77340view19:18, 22 August 2014AlexanderPicoLinked refs to pathway element
72117view23:15, 24 October 2013AlexanderPicoReplaced IKK node with actual complex of individual nodes
63186view20:45, 8 May 2013MaintBotUpdating gpml version
59090view22:08, 21 February 2013MaintBotUpdated Ensembl data source
48214view05:28, 17 May 2012MaintBotAutomatic update of PubChem xrefs
45247view18:33, 7 October 2011AlexanderPicoOntology Term : 'estrogen signaling pathway' added !
41039view23:15, 1 March 2011MaintBotRemoved redundant pathway information and comments
39752view06:49, 17 January 2011AlexanderPico
38812view08:50, 24 September 2010Jildaunucleus
34842view09:12, 27 January 2010Vtriver6Specify description
34841view09:10, 27 January 2010Vtriver6Specify description
34840view09:09, 27 January 2010Vtriver6Specify description
34839view09:06, 27 January 2010Vtriver6ER signaling
34838view07:51, 27 January 2010Vtriver6Periodical save, work in progress
33422view14:53, 30 November 2009MaintBotRemoved group label
29739view22:35, 1 June 2009KhanspersModified categories
29675view11:39, 26 May 2009LauravanzonSpecify description
29593view11:18, 20 May 2009LauravanzonSpecify description
29589view08:39, 19 May 2009LauravanzonSpecify description
29588view08:38, 19 May 2009LauravanzonSpecify description
29587view08:32, 19 May 2009LauravanzonModified description
29586view08:31, 19 May 2009LauravanzonSpecify description
29585view08:24, 19 May 2009LauravanzonSpecify description
29584view08:20, 19 May 2009LauravanzonPeriodical save, work in progress
29582view07:29, 19 May 2009LauravanzonSpecify description
29581view07:19, 19 May 2009LauravanzonSpecify description
29580view11:21, 18 May 2009LauravanzonSpecify description
29579view11:18, 18 May 2009LauravanzonSpecify description
29578view11:14, 18 May 2009LauravanzonPeriodical save, work in progress
29577view10:49, 18 May 2009Lauravanzon
29576view10:41, 18 May 2009LauravanzonPeriodical save, work in progress
29575view10:31, 18 May 2009LauravanzonPeriodical save, work in progress
29574view10:21, 18 May 2009LauravanzonPeriodical save, work in progress
29573view10:11, 18 May 2009LauravanzonPeriodical save, work in progress
29572view10:00, 18 May 2009LauravanzonPeriodical save, work in progress
29571view09:50, 18 May 2009LauravanzonPeriodical save, work in progress
29570view09:40, 18 May 2009LauravanzonPeriodical save, work in progress
29569view09:30, 18 May 2009LauravanzonPeriodical save, work in progress
29568view09:09, 18 May 2009LauravanzonPeriodical save, work in progress
29567view08:59, 18 May 2009LauravanzonPeriodical save, work in progress
29566view08:49, 18 May 2009LauravanzonPeriodical save, work in progress
29564view08:25, 18 May 2009LauravanzonPeriodical save, work in progress
29563view08:15, 18 May 2009LauravanzonPeriodical save, work in progress
29562view08:05, 18 May 2009LauravanzonPeriodical save, work in progress
29561view07:55, 18 May 2009LauravanzonNew pathway

External references

View all...
NameTypeDatabase referenceComment
IKBKBGeneProduct3551 (Entrez Gene)
MAPKKKGeneProduct673 (Entrez Gene)
SP1GeneProduct6667 (Entrez Gene)
Cyclic AMPMetaboliteHMDB00058 (HMDB)
EREGeneProduct2099 (Entrez Gene)
MAPKKGeneProductENSG00000169032 (Ensembl)
EstradiolMetaboliteHMDB00151 (HMDB)
GFRsGeneProduct2099 (Entrez Gene)
ER-AF1GeneProduct2099 (Entrez Gene)
PKB/AktGeneProduct207 (Entrez Gene)
ELKGeneProduct2002 (Entrez Gene)
GSAGeneProduct2778 (Entrez Gene)
ERK 1/2GeneProductENSG00000100030 (Ensembl)
CHUKGeneProduct1147 (Entrez Gene)
ERGeneProduct2099 (Entrez Gene)
C-FOSGeneProduct2353 (Entrez Gene)
ER-AF2GeneProduct2099 (Entrez Gene)
GNGT1GeneProduct2792 (Entrez Gene)
GPR30GeneProduct2852 (Entrez Gene)
GNB1GeneProduct2782 (Entrez Gene)
c-JunGeneProduct3725 (Entrez Gene)
CREBGeneProduct1385 (Entrez Gene)
PI3KGeneProduct5290 (Entrez Gene)
JNKsGeneProduct5601 (Entrez Gene)
Growth factorsMetaboliteHMDB00151 (HMDB)
p38GeneProduct1432 (Entrez Gene)
NFKBGeneProduct4790 (Entrez Gene)
PKACAGeneProduct5566 (Entrez Gene)
Non-EREGeneProduct2099 (Entrez Gene)
TFGeneProduct2099 (Entrez Gene)
BCL2 Apoptotic switchGeneProduct596 (Entrez Gene)
IKBKGGeneProduct8517 (Entrez Gene)
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