Tamoxifen metabolism (Homo sapiens)

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Description

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Ontology Tags

 

Bibliography

View all 5 references
  1. Jordan VC; ''Chemoprevention of breast cancer with selective oestrogen-receptor modulators.; ''Nat Rev Cancer, 2007 - PubMed
  2. Jordan VC; ''New insights into the metabolism of tamoxifen and its role in the treatment and prevention of breast cancer.; ''Steroids, 2007 - PubMed
  3. Kaku T, Ogura K, Nishiyama T, Ohnuma T, Muro K, Hiratsuka A; ''Quaternary ammonium-linked glucuronidation of tamoxifen by human liver microsomes and UDP-glucuronosyltransferase 1A4.; ''Biochem Pharmacol, 2004 - PubMed
  4. Lazarus P, Blevins-Primeau AS, Zheng Y, Sun D; ''Potential role of UGT pharmacogenetics in cancer treatment and prevention: focus on tamoxifen.; ''Ann N Y Acad Sci, 2009 - PubMed
  5. Ogura K, Ishikawa Y, Kaku T, Nishiyama T, Ohnuma T, Muro K, Hiratsuka A; ''Quaternary ammonium-linked glucuronidation of trans-4-hydroxytamoxifen, an active metabolite of tamoxifen, by human liver microsomes and UDP-glucuronosyltransferase 1A4.; ''Biochem Pharmacol, 2006 - PubMed

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History

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CompareRevisionActionTimeUserComment
59176view18:43, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
57002view13:40, 19 January 2013EgonwCorrected to the correct PubChem-compound data source.
48234view05:46, 17 May 2012MaintBotUpdating PubChem xrefs
48212view05:28, 17 May 2012MaintBotAutomatic update of PubChem xrefs
45101view22:07, 6 October 2011KhanspersOntology Term : 'estrogen-receptor positive breast cancer' added !
41135view23:38, 1 March 2011MaintBotRemoved redundant pathway information and comments
38734view21:31, 23 September 2010Khansperschanged arrow types
33408view14:49, 30 November 2009MaintBotRemoved group label
32747view23:23, 3 September 2009MaintBotModified categories
29331view12:42, 24 April 2009Pieter GiesbertzAdded compound identifiers
29330view12:25, 24 April 2009Pieter GiesbertzAdded compound identifiers
29329view11:13, 24 April 2009Pieter GiesbertzSpecify description
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29137view13:01, 6 April 2009Pieter GiesbertzPeriodical save, work in progress
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29118view08:20, 6 April 2009Pieter GiesbertzNew pathway

External references

View all 44...

Name Type Database reference
cis-4-hydroxytamoxifenMetabolite
MetaboliteMetabolite
trans-4-hydroxytamoxifenMetabolite449459 (PubChem-compound)
UGT2B7GeneProduct7364 (Entrez Gene)
N-desmethyltamoxifenMetabolite3032890 (PubChem-compound)
SULT1E1GeneProductENSG00000109193 (Ensembl)
CYP2D6GeneProductENSG00000100197 (Ensembl)
cis-tamoxifen-4-O-glucuronideMetabolite
4-hydroxy-N-desmethyltamoxifenMetabolite3035980 (PubChem-compound)
CYP1B1GeneProductENSG00000138061 (Ensembl)
CYP3A4GeneProductENSG00000160868 (Ensembl)
trans-4-SulfoxytamoxifenMetabolite
CYP3A5GeneProductENSG00000106258 (Ensembl)
PAPMetaboliteHMDB00061 (HMDB)
SSRIMetabolite
UGT1A4GeneProduct54657 (Entrez Gene)
N,N-didesmethyltamoxifenMetabolite3036172 (PubChem-compound)
trans-N-desmethyltamoxifen-O-glucuronideMetabolite
deamino-hydroxytamoxifenMetabolite3033897 (PubChem-compound)
UGT1A10GeneProduct54575 (Entrez Gene)
CYP2C9GeneProductENSG00000138109 (Ensembl)
trans-tamoxifenMetaboliteHMDB12287 (HMDB)
CYP2C19GeneProductENSG00000165841 (Ensembl)
SULT2A1GeneProductENSG00000105398 (Ensembl)
alpha-hydroxy-N-desmethyltamoxifenMetabolite
SULT1A1GeneProductENSG00000196502 (Ensembl)
alpha-hydroxytamoxifenMetabolite
PAPSMetabolite10214 (PubChem-compound)
Tamoxifen-N-oxideMetabolite
tamoxifen-N-glucuronideMetabolite5460873 (PubChem-compound)
FMO1GeneProductENSG00000010932 (Ensembl)
cis-4-hydroxy-N-desmethyltamoxifenMetabolite
FMO3GeneProductENSG00000007933 (Ensembl)
cis-4-hydroxytamoxifen-N-glucuronideMetabolite
CYP1A1GeneProductENSG00000140465 (Ensembl)
trans-tamoxifen-4-O-glucuronideMetabolite
CYP1A2GeneProductENSG00000140505 (Ensembl)
cis-N-desmethyltamoxifen-O-glucuronideMetabolite
CYP2A6GeneProductENSG00000213052 (Ensembl)
UGT1A8GeneProduct54576 (Entrez Gene)
CYP2C8GeneProductENSG00000138115 (Ensembl)
trans-4-hydroxytamoxifen-N-glucuronideMetabolite
CYP2E1GeneProductENSG00000130649 (Ensembl)
UGT2B15GeneProductENSG00000197592 (Ensembl)
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