Hypothetical Network for Drug Addiction (Homo sapiens)

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Adapted from figure 2 in Li et al..

Ontology Tags



  1. Li CY, Mao X, Wei L; ''Genes and (common) pathways underlying drug addiction.''; PLoS Comput Biol, 2008 PubMed


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68893view17:28, 8 July 2013MaintBotUpdated to 2013 gpml schema
67354view10:41, 26 June 2013Christine ChichesterOntology Term : 'substance dependence disease pathway' added !
45365view20:56, 7 October 2011AlexanderPicoOntology Term : 'drug dependence' added !
41043view23:16, 1 March 2011MaintBotRemoved redundant pathway information and comments
38828view11:48, 24 September 2010Jildaucomparments
33400view14:47, 30 November 2009MaintBotRemoved group label
29740view22:36, 1 June 2009KhanspersModified categories
28640view12:30, 19 February 2009ThomasModified description
28639view12:29, 19 February 2009Thomasadded literature
28638view12:28, 19 February 2009Thomas
28637view12:21, 19 February 2009ThomasPeriodical save, work in progress
28636view12:10, 19 February 2009ThomasPeriodical save, work in progress
28635view12:00, 19 February 2009ThomasPeriodical save, work in progress
28634view11:56, 19 February 2009Thomasnegative feedback
28633view11:50, 19 February 2009ThomasPeriodical save, work in progress
28632view11:45, 19 February 2009ThomasNew pathway

External references

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NameTypeDatabase referenceComment
PP1GeneProduct5464 (Entrez Gene)
AC8GeneProduct114 (Entrez Gene)
AC1GeneProduct107 (Entrez Gene)
GRM1GeneProduct2911 (Entrez Gene)
DRD4GeneProduct1815 (Entrez Gene)
NR1GeneProduct2902 (Entrez Gene)
ACTA1GeneProduct58 (Entrez Gene)
GRIA1GeneProduct2890 (Entrez Gene)
MEK2GeneProduct5605 (Entrez Gene)
GRIA2GeneProduct2891 (Entrez Gene)
PKCGeneProduct5581 (Entrez Gene)
GRIA3GeneProduct2892 (Entrez Gene)
DRD1GeneProduct1812 (Entrez Gene)
GRIA4GeneProduct2893 (Entrez Gene)
ERK1GeneProduct5595 (Entrez Gene)
GRIN2AGeneProduct2903 (Entrez Gene)
CAMK4GeneProduct814 (Entrez Gene)
GRIN2BGeneProduct2904 (Entrez Gene)
MEK1GeneProduct5604 (Entrez Gene)
GRIN2CGeneProduct2905 (Entrez Gene)
I-1GeneProduct11188 (Entrez Gene)
GRIN2DGeneProduct2906 (Entrez Gene)
CAMK2GeneProduct816 (Entrez Gene)
GRM5GeneProduct2915 (Entrez Gene)
CAMGeneProduct889 (Entrez Gene)
D-GlutamateMetabolite15966 (ChEBI)
DRD2GeneProduct1813 (Entrez Gene)
Ca++Metabolite29320 (ChEBI)
Cyclic AMPMetabolite17489 (ChEBI)
ADCY1GeneProduct107 (Entrez Gene)
PKAGeneProduct5566 (Entrez Gene)
ERK2GeneProduct5594 (Entrez Gene)
RAP1GeneProduct54386 (Entrez Gene)
CREBGeneProduct1385 (Entrez Gene)
RAFGeneProduct22882 (Entrez Gene)
connexinGeneProduct375519 (Entrez Gene)
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