Complement and Coagulation Cascades (Homo sapiens)

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Curation Tags

Description

Blood coagulation is a series of coordinated and calcium-dependent proenzyme-to-serine protease conversions likely to be localized on the surfaces of activated cells in vivo. It culminates in the formation of thrombin, the enzyme responsible for the conversion of soluble fibrinogen to the insoluble fibrin clot.

The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). Kinin peptides are implicated in many physiological and pathological processes including the regulation of blood pressure and sodium homeostasis, inflammatory processes, and the cardioprotective effects of preconditioning. Complement is a system of plasma proteins that is activated by the presence of pathogens. There are three pathways of complement activation: the classical pathway, the lectin pathway, and the alternative pathway. All of these pathways generate a crucial enzymatic activity that, intern, generates the effector molecules of complement. The three main consequences of complement activation are the opsonization of pathogens, the recruitment of inflammatory and immunocompetent cells, and the direct killing of pathogens.

Source: KEGG (http://www.genome.jp/dbget-bin/www_bget?pathway:map04610)

Comments

GenMAPP notes 
http://www.genome.jp/dbget-bin/www_bget?pathway:map04610
GenMAPP remarks 
Adapted from KEGG

Ontology Tags

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
67786view15:14, 26 June 2013DdiglesOntology Term : 'complement system pathway' added !
63170view20:26, 8 May 2013MaintBotUpdating gpml version
59169view18:34, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
45058view19:54, 6 October 2011AlexanderPicoadded db ref
41101view23:22, 1 March 2011MaintBotRemoved redundant pathway information and comments
38701view19:26, 23 September 2010AlexanderPico
36243view19:16, 11 March 2010LslabimD2 coag comp
36242view19:12, 11 March 2010LslabimPeriodical save, work in progress
36241view18:41, 11 March 2010LslabimD2 effect coag comp
36240view18:32, 11 March 2010LslabimPeriodical save, work in progress
36239view18:21, 11 March 2010LslabimPeriodical save, work in progress
34809view00:23, 21 January 2010KhanspersChanged comment
34808view00:22, 21 January 2010KhanspersModified description
34807view00:20, 21 January 2010KhanspersModified description
34467view18:30, 10 December 2009MaintBotAutomatic update of empty xrefs
32465view17:28, 15 August 2009MaintBotFixed text labels
32149view14:01, 14 August 2009MaintBotFixed group labels
22582view13:34, 14 November 2008Thomaschanged name (was duplicate with WP545)
21854view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:Complement and Coagulation Cascades KEGG]] moved to [[Pathway:WP558]]: Moved to stable identifier
14616view07:15, 23 May 2008Thomasadded groups and linked lines
14612view07:09, 23 May 2008ThomasPeriodical save, work in progress
14608view06:49, 23 May 2008ThomasPeriodical save, work in progress
13052view11:11, 17 May 2008MaintBotautomated metabolite conversion
12930view10:41, 17 May 2008MaintBotSticky edges patch by Sjoerd
7972view13:46, 7 January 2008MaintBot[[Pathway:Human:Complement and Coagulation Cascades KEGG]] moved to [[Pathway:Homo sapiens:Complement and Coagulation Cascades KEGG]]: Renaming species
7610view16:04, 18 December 2007MaintBotfixed category names
7467view12:42, 4 November 2007MaintBotAdded categories to GPML
6305view22:17, 22 May 2007169.230.77.174gpml file for [[Human:Complement_and_Coagulation_Cascades_KEGG]]

External references

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NameTypeDatabase referenceComment
BradykininMetabolite58-82-2 (CAS)
C1QAGeneProduct712 (Entrez Gene)
PROCGeneProduct5624 (Entrez Gene)
C1QGGeneProduct714 (Entrez Gene)
CPB2GeneProduct1361 (Entrez Gene)
C1RGeneProduct715 (Entrez Gene)
F12GeneProduct2161 (Entrez Gene)
C1SGeneProduct716 (Entrez Gene)
F5GeneProduct2153 (Entrez Gene)
Daf2GeneProductDaf2 (Entrez Gene)
SERPINC1GeneProduct462 (Entrez Gene)
Daf1GeneProductDaf1 (Entrez Gene)
THBDGeneProduct7056 (Entrez Gene)
C2GeneProduct717 (Entrez Gene)
BDKRB1GeneProduct623 (Entrez Gene)
C4GeneProductC4 (Entrez Gene)
C1QBGeneProduct713 (Entrez Gene)
C3GeneProduct718 (Entrez Gene)
FGBGeneProduct2244 (Entrez Gene)
HcGeneProductHc (Entrez Gene)
F13BGeneProduct2165 (Entrez Gene)
C6GeneProduct729 (Entrez Gene)
A2MGeneProduct2 (Entrez Gene)
C9GeneProduct735 (Entrez Gene)
PLATGeneProduct5327 (Entrez Gene)
MASP1GeneProduct5648 (Entrez Gene)
PLAURGeneProduct5329 (Entrez Gene)
CD59AGeneProductCD59A (Entrez Gene)
KNG1GeneProduct3827 (Entrez Gene)
MCPGeneProduct4179 (Entrez Gene)
C8GGeneProduct733 (Entrez Gene)
CRRYGeneProductCRRY (Entrez Gene)
PrM/CapGeneProduct
CFIGeneProductCFI (Entrez Gene)
F10GeneProduct2159 (Entrez Gene)
MASP2GeneProduct10747 (Entrez Gene)
F2GeneProduct2147 (Entrez Gene)
MBL1GeneProductMBL1 (Entrez Gene)
SERPIND1GeneProduct3053 (Entrez Gene)
SERPING1GeneProduct710 (Entrez Gene)
TFPIGeneProduct7035 (Entrez Gene)
C3AR1GeneProduct719 (Entrez Gene)
F2RGeneProduct2149 (Entrez Gene)
C5R1GeneProduct728 (Entrez Gene)
SERPINA5GeneProduct5104 (Entrez Gene)
CR2GeneProduct1380 (Entrez Gene)
SERPINA1GeneProduct5265 (Entrez Gene)
CR1GeneProduct1378 (Entrez Gene)
PROS1GeneProduct5627 (Entrez Gene)
H2-BFGeneProductH2-BF (Entrez Gene)
PLAUGeneProduct5328 (Entrez Gene)
ADNGeneProductADN (Entrez Gene)
SERPINE1GeneProduct5054 (Entrez Gene)
CFHGeneProductCFH (Entrez Gene)
PLGGeneProduct5340 (Entrez Gene)
F3GeneProduct2152 (Entrez Gene)
KLKB1GeneProduct3818 (Entrez Gene)
F7GeneProduct2155 (Entrez Gene)
SERPINF2GeneProduct5345 (Entrez Gene)
F9GeneProduct2158 (Entrez Gene)
C7GeneProduct730 (Entrez Gene) MGI:88235 LL:109828
F8GeneProduct2157 (Entrez Gene)
Fibrin monomerMetabolite9001-31-4 (CAS)
109821GeneProduct109821 (Entrez Gene)
CLUGeneProductCLU (Entrez Gene)
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VWFGeneProduct7450 (Entrez Gene)
APOA2GeneProductENSG00000158874 (Ensembl)
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