ACE Inhibitor Pathway (Homo sapiens)

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Description

The renin-angiotensin-aldosterone system (RAAS) is central to the control of blood pressure and the target of several types of anti-hypertensive drugs. This pathway depicts a simplified representation of the pharmacodynamics (PD) of RAAS-acting drugs including candidate genes for the pharmacogenomics (PGx) of ACE inhibitors, angiotensin receptor blockers (ARBs), renin inhibitor aliskiren and aldosterone receptor antagonists.

Source: PharmGKB (http://www.pharmgkb.org/do/serve?objId=PA2023&objCls=Pathway)


Comments

GenMAPP remarks 
Adapted from PharmGKB

Bibliography

View all 9 references
  1. Hamming I, Cooper ME, Haagmans BL, Hooper NM, Korstanje R, Osterhaus AD, Timens W, Turner AJ, Navis G, van Goor H; ''The emerging role of ACE2 in physiology and disease.; ''J Pathol, 2007 - PubMed
  2. Batenburg WW, Jan Danser AH; ''The (pro)renin receptor: a new addition to the renin-angiotensin system?; ''Eur J Pharmacol, 2008 - PubMed
  3. McDowell SE, Coleman JJ, Ferner RE; ''Systematic review and meta-analysis of ethnic differences in risks of adverse reactions to drugs used in cardiovascular medicine.; ''BMJ, 2006 - PubMed
  4. Schwartz GL, Turner ST; ''Pharmacogenetics of antihypertensive drug responses.; ''Am J Pharmacogenomics, 2004 - PubMed
  5. Athyros VG, Mikhailidis DP, Kakafika AI, Tziomalos K, Karagiannis A; ''Angiotensin II reactivation and aldosterone escape phenomena in renin-angiotensin-aldosterone system blockade: is oral renin inhibition the solution?; ''Expert Opin Pharmacother, 2007 - PubMed
  6. Ferreira AJ, Raizada MK; ''Are we poised to target ACE2 for the next generation of antihypertensives?; ''J Mol Med, 2008 - PubMed
  7. Maron BA, Leopold JA; ''Mineralocorticoid receptor antagonists and endothelial function.; ''Curr Opin Investig Drugs, 2008 - PubMed
  8. Bassett MH, White PC, Rainey WE; ''The regulation of aldosterone synthase expression.; ''Mol Cell Endocrinol, 2004 - PubMed
  9. Weir MR; ''Effects of renin-angiotensin system inhibition on end-organ protection: can we do better?; ''Clin Ther, 2007 - PubMed

Categories

History

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CompareRevisionActionTimeUserComment
38365view23:44, 2 September 2010KhanspersNew version uploaded
34805view23:49, 20 January 2010KhanspersModified description
34804view23:49, 20 January 2010KhanspersDeleted reference
34803view23:43, 20 January 2010KhanspersModified description
34802view23:41, 20 January 2010KhanspersDeleted reference
34801view23:30, 20 January 2010KhanspersPeriodical save, work in progress
34800view23:18, 20 January 2010KhanspersAdded citation
34799view23:18, 20 January 2010KhanspersChanged comments
34798view23:16, 20 January 2010KhanspersModified description
32148view14:00, 14 August 2009MaintBotFixed group labels
30178view20:31, 7 July 2009KhanspersAdded xref for angiotensinII
22578view13:30, 14 November 2008Thomasremoved redundant organism name after title
21846view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:ACE-Inhibitor pathway PharmGKB]] moved to [[Pathway:WP554]]: Moved to stable identifier
14510view01:16, 23 May 2008AlexanderPicoConnected, grouped and fixed metabolites
13026view11:07, 17 May 2008MaintBotSticky edges patch by Sjoerd
11883view18:19, 8 May 2008KhanspersChanged contact info
11445view21:52, 29 March 2008JinwookPeriodical save, work in progress
10186view12:20, 15 January 2008MaintBotadded literature
7872view13:46, 7 January 2008MaintBot[[Pathway:Human:ACE-Inhibitor pathway PharmGKB]] moved to [[Pathway:Homo sapiens:ACE-Inhibitor pathway PharmGKB]]: Renaming species
7561view16:00, 18 December 2007MaintBotfixed category names
7449view12:42, 4 November 2007MaintBotAdded categories to GPML
6289view22:17, 22 May 2007C.F.ThornUploaded from wpi.php

Pathway Info

DataNodes

View all 27 DataNodes

Name Type Backpage Header Database reference
NOS3GeneProduct4846 (Entrez Gene)
ATP6AP2GeneProduct10159 (Entrez Gene)
MAS1GeneProduct4142 (Entrez Gene)
ACE2GeneProduct59272 (Entrez Gene)
ACEGeneProduct1636 (Entrez Gene)
Ca++MetaboliteHMDB00464 (HMDB)
TGFB1GeneProduct7040 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
BradykininMetaboliteHMDB04246 (HMDB)
Angiotensin IMetabolite3081372 (PubChem)
MAPK3GeneProduct5595 (Entrez Gene)
RENGeneProduct5972 (Entrez Gene)
KNG1GeneProduct3827 (Entrez Gene)
AGTR1GeneProduct185 (Entrez Gene)
BDKRB2GeneProduct624 (Entrez Gene)
Ang 1-5Metabolite
NR3C2GeneProduct4306 (Entrez Gene)
CTSGGeneProduct1511 (Entrez Gene)
Angiotensin IIMetaboliteHMDB01035 (HMDB)
BDKRB1GeneProduct623 (Entrez Gene)
AGTR2GeneProduct186 (Entrez Gene)
AGTGeneProduct183 (Entrez Gene)
CMA1GeneProduct1215 (Entrez Gene)
CYP11B2GeneProduct1585 (Entrez Gene)
ACE InhibitorMetabolite
AldosteroneMetaboliteC01780
Ang 1-9 Metabolite
Retrieved from "http://www.wikipathways.org/index.php/Pathway:WP554"
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