Glycolysis and Gluconeogenesis (Homo sapiens)

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Description

Glycolysis is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO− + H+. The free energy released in this process is used to form the ATP and NADH.

Gluconeogenesis is a metabolic pathway that results in the generation of glucose from non-carbohydrate carbon substrates such as pyruvate, lactate, glycerol, glucogenic amino acids, and fatty acids.

Description adapted from Wikipedia.

Ontology Tags

 

Bibliography

  1. Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen YC, Cox JE, Cardon CM, Van Vranken JG, Dephoure N, Redin C, Boudina S, Gygi SP, Brivet M, Thummel CS, Rutter J; ''A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans.''; Science, 2012 PubMed

History

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CompareRevisionActionTimeUserComment
90450view21:05, 16 November 2016KhanspersReverted to version '06:22, 10 September 2016' by Khanspers
90290view22:57, 2 November 2016MirkoBaranziniSpecify description
90289view22:55, 2 November 2016MirkoBaranziniPeriodical save, work in progress
90268view06:39, 28 October 2016MirkoBaranziniSpecify description
90267view06:37, 28 October 2016MirkoBaranziniSpecify description
90256view08:48, 27 October 2016MirkoBaranziniPeriodical save, work in progress
90255view08:36, 27 October 2016MirkoBaranziniPeriodical save, work in progress
90254view08:26, 27 October 2016MirkoBaranziniPeriodical save, work in progress
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90250view22:22, 26 October 2016MirkoBaranziniSpecify description
90249view21:53, 26 October 2016MirkoBaranzinisxq
90248view21:49, 26 October 2016MirkoBaranziniSpecify description
90246view20:35, 26 October 2016MirkoBaranziniPeriodical save, work in progress
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90238view11:56, 26 October 2016MirkoBaranziniGlicolisi1
90237view11:54, 26 October 2016MirkoBaranziniSpecify description
90236view11:50, 26 October 2016MirkoBaranziniPeriodical save, work in progress
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90234view11:36, 26 October 2016MirkoBaranziniSpecify description
90233view11:17, 26 October 2016MirkoBaranziniPeriodical save, work in progress
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90230view10:56, 26 October 2016MirkoBaranziniGlicolisi 1
90229view10:55, 26 October 2016MirkoBaranziniPeriodical save, work in progress
90228view10:50, 26 October 2016MirkoBaranziniSpecify description
90227view10:45, 26 October 2016MirkoBaranziniPeriodical save, work in progress
90226view10:40, 26 October 2016MirkoBaranziniglico1
90223view10:35, 26 October 2016MirkoBaranziniPeriodical save, work in progress
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90218view09:34, 26 October 2016MirkoBaranziniPeriodical save, work in progress
90217view09:24, 26 October 2016MirkoBaranziniPeriodical save, work in progress
90216view09:14, 26 October 2016MirkoBaranziniPeriodical save, work in progress
90215view09:12, 26 October 2016MirkoBaranziniSpecify description
90214view09:04, 26 October 2016MirkoBaranziniPeriodical save, work in progress
90213view09:03, 26 October 2016MirkoBaranziniglico 1
90212view08:54, 26 October 2016MirkoBaranziniPeriodical save, work in progress
90211view08:44, 26 October 2016MirkoBaranziniPeriodical save, work in progress
89372view06:22, 10 September 2016EgonwConverted to interactions to graphical lines in the legend.
78585view14:50, 7 January 2015MaintBotadded missing graphIds
74524view21:59, 28 April 2014KhanspersModified description
74517view17:08, 28 April 2014The HeraldModified description
72028view12:56, 24 October 2013Mkutmonfixed unconnected lines
69349view18:52, 8 July 2013EgonwReplaced an HMDB identifier of a charged species (removed in 3.5) with the uncharged one.
68053view12:43, 29 June 2013EgonwAdded a link naar de WP325 pathway.
63202view20:54, 8 May 2013MaintBotUpdating gpml version
59845view20:38, 8 March 2013KhanspersAdded rectangles to pathway nodes
59844view20:15, 8 March 2013KhanspersUpdated db ref for lactate

External references

Datanodes

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NameTypeDatabase referenceComment
1,3BP-GlycerateMetaboliteHMDB01270 (HMDB)
2P-GlycerateMetaboliteHMDB00362 (HMDB)
3P-GlycerateMetaboliteHMDB00807 (HMDB)
ALDOAGeneProduct226 (Entrez Gene)
ALDOBGeneProduct229 (Entrez Gene)
ALDOCGeneProduct230 (Entrez Gene)
Acetyl-CoAMetaboliteHMDB01206 (HMDB)
AspartateMetaboliteHMDB00191 (HMDB)
DLATGeneProduct1737 (Entrez Gene)
DLDGeneProduct1738 (Entrez Gene)
Dihydroxyacetone-PMetaboliteHMDB01473 (HMDB)
ENO1GeneProduct2023 (Entrez Gene)
ENO2GeneProduct2026 (Entrez Gene)
ENO3GeneProduct2027 (Entrez Gene)
FBP1GeneProduct2203 (Entrez Gene)
FBP2GeneProduct8789 (Entrez Gene)
Fructose 6PMetaboliteHMDB00124 (HMDB)
Fructose-1,6BPMetaboliteHMDB01058 (HMDB)
G6PCGeneProduct2538 (Entrez Gene) Not present in brain and muscle, so those organs can not produce their own glucose in the gluconeogenesis pathway
GAPDHGeneProductENSG00000111640 (Ensembl)
GAPDHSGeneProduct26330 (Entrez Gene)
GCKGeneProduct2645 (Entrez Gene) Gck is mainly active in liver
GOT1GeneProduct2805 (Entrez Gene)
GOT2GeneProduct2806 (Entrez Gene)
GPIGeneProduct2821 (Entrez Gene)
Glucose-6PMetaboliteHMDB01401 (HMDB)
GlucoseMetaboliteHMDB00122 (HMDB)
Glyceraldehyde 3PMetaboliteHMDB01112 (HMDB)
Glycogen metabolismPathwayWP500 (WikiPathways)
HK1GeneProduct3098 (Entrez Gene)
HK2GeneProduct3099 (Entrez Gene)
HK3GeneProduct3101 (Entrez Gene)
LDHAGeneProduct3939 (Entrez Gene)
LDHAL6BGeneProduct92483 (Entrez Gene)
LDHBGeneProduct3945 (Entrez Gene)
LDHCGeneProduct3948 (Entrez Gene)
LactateMetaboliteHMDB00190 (HMDB)
MDH1GeneProduct4190 (Entrez Gene)
MDH2GeneProduct4191 (Entrez Gene)
MPC1GeneProduct51660 (Entrez Gene)
MPC2GeneProduct25874 (Entrez Gene)
MalateMetaboliteHMDB00744 (HMDB)
OxaloacetateMetaboliteHMDB00223 (HMDB)
P-enolpyruvateMetaboliteHMDB00263 (HMDB)
PCGeneProduct5091 (Entrez Gene)
PCK1GeneProduct5105 (Entrez Gene)
PDHA1GeneProduct5160 (Entrez Gene)
PDHA2GeneProduct5161 (Entrez Gene)
PDHBGeneProduct5162 (Entrez Gene)
PDHXGeneProduct8050 (Entrez Gene)
PFKLGeneProduct5211 (Entrez Gene)
PFKMGeneProduct5213 (Entrez Gene)
PFKPGeneProduct5214 (Entrez Gene)
PGAM1GeneProduct5223 (Entrez Gene)
PGAM2GeneProduct5224 (Entrez Gene)
PGK1GeneProduct5230 (Entrez Gene)
PGK2GeneProduct5232 (Entrez Gene)
PKLRGeneProduct5313 (Entrez Gene)
PKM2GeneProduct5315 (Entrez Gene)
Pentose Phosphate PathwayPathwayWP134 (WikiPathways)
PyruvateMetaboliteHMDB00243 (HMDB)
SLC2A1GeneProduct6513 (Entrez Gene)
SLC2A2GeneProduct6514 (Entrez Gene)
SLC2A3GeneProduct6515 (Entrez Gene)
SLC2A4GeneProduct6517 (Entrez Gene)
SLC2A5GeneProduct6518 (Entrez Gene)
TCA CyclePathwayWP78 (WikiPathways)
TPI1GeneProduct7167 (Entrez Gene)
Triglyceride synthesisPathwayWP325 (WikiPathways)

Annotated Interactions

No annotated interactions

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